ENHANCEMENT OF BIOAVAILABILITY OF GLIPIZIDE USING SOLID DISPERSIONS WITH GUM AEGLE MARMELOS

Authors

  • S. MALLICK Royal College of Pharmacy And Health Sciences, Andhapasara Road, Berhampur-760002, Odisha, India
  • A. K. MAHAPATRA Royal College of Pharmacy And Health Sciences, Andhapasara Road, Berhampur-760002, Odisha, India
  • P. N. MURTHY Royal College of Pharmacy And Health Sciences, Andhapasara Road, Berhampur-760002, Odisha, India https://orcid.org/0000-0001-9649-7848
  • RUCHITA KUMARI PATRA Royal College of Pharmacy And Health Sciences, Andhapasara Road, Berhampur-760002, Odisha, India

DOI:

https://doi.org/10.22159/ijap.2022v14i2.43518

Keywords:

Glipizide; Solid dispersion; Aegle marmelos; Solubility; Dissolution

Abstract

Objective: The aim of the proposed study was formulation and in vitro/ vivo evolution   of solid dispersions of glipizide with gum Aegle marmelos.

Methods: The phase solubility of glipizide in 0.1N HCl was investigated in the presence of different concentrations of gum Aegle marmelos. The solid dispersions (SDs) of glipizide with gum Aegle marmelos were formulated using solvent evaporation method at ratios of 1:1, 1:2, and 1:5 (glipizide: gum Aegle marmelos). Dissolution studies were conducted. The physicochemical characterization of the formulations was performed by using Fourier-transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC) and X-ray diffraction (XRD). Subsequently, bioavailability of pure glipizide, solid dispersion and marketed product was performed in rat.

Results: Glipizide solubility increased as the concentration of gum Aegle marmelos in 0.1N HCl was raised. The solubility study indicates spontaneous drug solubilization, which is supported by negative values of Gibb's free energy (ΔGotr). Glipizide rate of dissolution was increased in SDs containing gum, and the rate increased as the concentration of gum in the SDs increases. After preparing SDs and physical mixtures with gum, the mean dissolution time (MDT) of glipizide decreases considerably. FTIR spectroscopy study revealed that stability and the absence of a well-defined glipizide-gum interaction. The amorphous condition of glipizide in SDs of glipizide with gum was revealed by DSC and XRD studies.

Conclusion: The DSC and XRD studies indicate conversion of drug from crystalline to microcrystalline or amorphous form after formulation of solid dispersion with Aegle gum. The solid dispersion of glipizide with Aegle gum (893.04±25.5) showed better therapeutic activity compared to pure glipizide (535.65±11.5) and marketed formulation (767.5±13.6).

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Published

15-12-2021

How to Cite

MALLICK, S., MAHAPATRA, A. K., MURTHY, P. N., & PATRA, R. K. (2021). ENHANCEMENT OF BIOAVAILABILITY OF GLIPIZIDE USING SOLID DISPERSIONS WITH GUM AEGLE MARMELOS. International Journal of Applied Pharmaceutics, 14(2). https://doi.org/10.22159/ijap.2022v14i2.43518

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