IDENTIFICATION POTENTIAL ACTIVITY OF VOLATILE COMPOUNDS DERIVED FROM POGOSTEMON CABLIN BENTH AS ANTIVIRAL OF SARS-COV-2

Authors

  • YULANDA ANTONIUS Department of Biology, Faculty of Biotechnology, University of Surabaya, Indonesia https://orcid.org/0000-0002-4950-8134
  • JEREMI ONGKO Department of Biology, Faculty of Biotechnology, University of Surabaya, Indonesia
  • POPY HARTATIE HARDJO Department of Biology, Faculty of Biotechnology, University of Surabaya, Indonesia https://orcid.org/0000-0002-9064-8470

DOI:

https://doi.org/10.22159/ijap.2023v15i1.43571

Keywords:

Inhibitor compound, glycoprotein, secondary metabolite, viral infection

Abstract

Objective: Coronavirus disease-19 (COVID-19) is global pandemic which caused by SARS-CoV-2 infection. Mechanism of infection is initiated by attachment between viral glycoprotein with ACE2 receptor in human cells. Furthermore, Indonesia had a massive diversity of plants with high potency of drugs, such as Pogostemon cablin Benth. In brief, it contained of various volatile compound with many therapeutic properties. Therefore, this research aimed to identify the ability of volatile compounds from Pogostemon cablin Benth as potential inhibitor of SARS-CoV-2 spike glycoprotein.

Methods: SMILE notation of 22 volatile compounds of Pogostemon cablin Benth were collected from PubChem and the 3D structure of SARS-CoV-2 glycoprotein (PDB ID: 6VXX) was obtained from PDB database. Simulation of interaction between volatile compound and glycoprotein was conducted by using Pyrx molecular docking. Moreover, complex of compounds-glycoprotein was depicted by using Chimera and amino acid residue was analysed by using LigPlot. Selected potential compounds were identified for biological activity prediction, druglikeness, and toxicity analysis.

Results: Analysis showed that among those volatile compounds, only caryophyllene oxide (-6.3 kcal/mol) that naturally bind specific into RBD site as compared to control. Furthermore, it had comparable hydrogen and hydrophobic interactions with glycoprotein. Further analysis showed it has strong potential biological function for antiviral with low toxicity.

Conclusion: caryophyllene oxide is considered as promising candidate compounds that inhibited viral infection through SARS-CoV-2 glycoprotein.

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Published

21-11-2022

How to Cite

ANTONIUS, Y., ONGKO, J., & HARDJO, P. H. (2022). IDENTIFICATION POTENTIAL ACTIVITY OF VOLATILE COMPOUNDS DERIVED FROM POGOSTEMON CABLIN BENTH AS ANTIVIRAL OF SARS-COV-2. International Journal of Applied Pharmaceutics, 15(1). https://doi.org/10.22159/ijap.2023v15i1.43571

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