ANALYSIS OF IN VITRO DISINTEGRATION AND DISSOLUTION EFFECT OF CUCURBITA MAXIMA STARCH IN LOSARTAN FDT

Authors

  • NINA VARGHESE School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced studies (VISTAS), Chennai 600117
  • M. KOMALA School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced studies (VISTAS), Chennai 600117

DOI:

https://doi.org/10.22159/ijap.2022v14i4.43852

Keywords:

Cucurbita maxima;, Fast disintegration tablet, Direct compression, Superdisintegrant, Losartan

Abstract

Objective: In this work, Curcurbita maxima was used as a superdisintegrant in the preparation of fast dissolving tablets containing Losartan. A Losartan is readily ionized in the presence of an acidic pH, resulting in decreased absorption via the GIT. Superdisintegrant can be used to solve this problem.

Methods: Losartan fast-dissolving tablets were made using the direct compression method and two distinct superdisintegrants, derived starch and Curcurbita maxima mucilage, in various quantities. Eleven formulations with varied concentrations of superdisintegrants were created to determine their efficacy and critical concentration levels. For each formulation, several pre-compression and post-compression assessment parameters were used.

Results: The disintegration time of the FDT (F1-F4) prepared with derived starch ranges from 4.28 ± 1.02 min to 8.20 ± 1.02 min, while the disintegration time of the FDT (F5-F8) prepared with Cucurbita maxima starch ranges from 1.02 ± 0.02 min to 5.02 ± 1.02 min. The remaining three formulations, F9-F11, have a disintegration time of more than 10 minutes. In comparison to other formulations, FDT containing Curcurbita maxima mucilage demonstrated improved organoleptic qualities, as well as outstanding in vitro disintegration and dissolution drug release.

Conclusion: It was determined that a lower concentration of Cucurbita maxima starch (10 mg) was the optimal concentration level for the Losartan FDT formulation.

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References

Malviya Rishabha, Srivastava Pranati, Bansal Mayank, Sharma P. K.Preparation and evaluation of disintegrating properties of Cucurbita maxima Pulp Powder.Int.J.Ph.Sci 2010;2:395-99

Neeti Anand, Lalit Singh R,Vijay Sharma. Natural superdisintegrant Oro-Dispersible Tablets. Int.Res.J.Pharm, 2013; 4: 33-38.

GokulGhenge SD Pande, Anwar Ahmad, Lalit Jejurkar, Tushar Birari. Development and characterization of fast disintegrating tablet of amlodipine besylate using mucilage of plantagoovata as a natural superdisintegrant. Int J Pharmtech Res 2011; 3: 938-45.

Harshal Pawar, ChhayaVarkhade, PravinJadhav, KavitaMehra. Development and evaluation of orodispersible tablets using a natural polysaccharide isolated from cassia toraseeds. Integr Med Res 2014; 3: 91–8.

Chauhan K, Solanki R, Sharma S. A review on fast dissolving tablet. International Journal of Applied Pharmaceutics, 2018; 10: 1–7.

Hoover R. Composition, molecular structure and physiochemical properties of tuber and root starch: A critical review. Carbohydr Polym 2001; 45:253-67.

Okunlola A, Odeku OA. Evaluation of starches obtainedfrom four Dioscorea species as binding agent in chloroquinephosphate tablet formulations. Saudi Pharm J 2011; 19:95–9.

Olayemi OJ, Oyi AR., Allagh TS. Comparative evaluation of maize, rice and wheat starch powders as pharmaceutical excipients.Nig.Pharm.Sci.2008; 7/; 131–8.

Oluwatoyin A. Odeku, Potentials of tropical starches as pharmaceutical excipients: A review. Strach / Starke 2013; 65: 89-106.

Pandey VP, Joysa Ruby J. A review on orodispersible tablet. World journal of pharmacy and pharmaceutical sciences 2014; 9: 129-35.

Bhide P, Nachinolkar R. Formulation development and characterization of meclizine hydrochloride fast dissolving tablets using solid dispersion technique. International Journal of Applied Pharmaceutics 2018; 10:141–46.

Sarafadeen AA, Eugenie BM, Oludele, A. Comparative disintegrant activities of breadfruit starch and official cornstarch. Powder Technol.2008; 181:98–103.

Shireesh KR, Vishnu P, Ravendrababu B, Sudeerbabu B, Naveenbabu K, Prasad MVV. Influence of various super disintegrating agents on the aceclofenac fast dissolving tablets. Res J Pharm Bio Chem Sci 2011; 2:99-105.

Lim TK. Edible Medicinal and Non-medicinal Plants. Fruits 2012; 1:293.

Chandra sekhar naik, Bharathi, and Basaveswara rao. Design and formulation development of fast-dissolving tablets of ibuprofen using novel natural superdisintegrant. Asian Journal of Pharmaceutical and Clinical Research 2019; 12: 34-41.

Ayorinde JO, Odeniyi MA. Disintegrant Properties of Native and Modified Polymers in Metronidazole Tablet Formulations. African Journal of Biomedical Research. 2014; 17: 1-12.

Akanbi TO, Nazamid S, Adebowale A. Functional and pasting properties of a tropical breadfruit (Artocarpus altilis) starch from lie-lfe, Osun State, Nigeria. Int. Food Res. J. 2009, 16, 151-7.

Atichokudomchai N, Shobsngob S, Chinachoti P, Varavinit SA. Study of some physicochemical properties of high-crystalline tapioca starch.Starch/Stärke 2001; 53:577–81.

Bakara HA, Osundahunsi OF, Adegunwa MO. Composition and pasting properties of breadfruit (Artocarpus communis Forst) from South –West states of Nigeria, Nigerian Food Journal. 2012; 30:11-7.

Suhas MK, Vinod SM, Ketan BR, Ayaz AD, Chirag VN, Avinash B. Formulation and evaluation of mouth dissolving tablets of losartan potassium by direct compression techniques.Int J Res Pharm Sci 2010;1:290-95.

Battue SK, Repay MA, Maunder S Rio. Formulation and evaluation of rapidly disintegrating tablet fenoverine tablets, effect of superdisintegrants, Drug Dev Ind Pharm, 2007; 33: 1225–32.

Rakesh Pahwa, Nisha Gupta. Superdisintegrants in the development of orally disintegrating tablets. A Review, IJPSR 2011; 11: 2767-80.

Bhupendra G. Prajapati1, Satish N Patel. Formulation, Evaluation and Optimization of Orally Disintegrating Tablet of Cinnarizine. E-Journal of Science & Technology 2010; 5:5.

BoeyJiaHui, Kunchu Kavitha, Kumutha Subramaniam, Kumaraswamy Santhi, Sokalingam Arumugam Dhanaraj, Mani Rupeshkumar. Role of superdisintegrants in the design of fast dissolving drug delivery systems - a review. IJAPR 2013; 1: 2475 – 83.

DivyaVishwakarma, Kanu.R.Patel, Natvarlal.M.Patel. Formulation and evaluation of metoprolol tartrate fast dissolving tablet. Am J Pharmtech Res 2012; 2:4?

Gohel MC, Parikh RK, Brahmbhatt BK, Shah AR. Preparation and assessment of novel coprocessed super-disintegrant consisting of crospovidone and sodium starchglycolate: A technical note. AAPS PharmSciTech.2007; 8:1-8.

Harshal Pawar, ChhayaVarkhade, PravinJadhav, KavitaMehra. Development and evaluation of orodispersible tablets using a natural polysaccharide isolated from cassia toraseeds. Integr Med Res 2014; 3: 91–8.

Ayorinde JO, Odeniyi. Disintegrant properties of native and modified polymers in metronidazole tablet formulations. African Journal of Biomedical Research. 2014; 17:3.

Jivraj, M, Martini LG, Thomson MC. An overview of the different excipients useful for the direct compression of tablets. Pharm Sci Technol. 2000; 3:58–63.

Mallikarjuna Rao K, Gnanaprakash K, Sridhar N,.Ramkanth S, Srinivasulu M, Madhusudhana Chety C. Design and characterization of mouth dissolving tablets of zidovudine by using superdisintegrant and solubilizing agent. Journal of Pharmacy Research 2010; 3:1764-68.

Kottke MK, .Chueh HR and Rhodes CT., Comparison of disintegrant and binder activity of three corn starch products. Drug Dev. Ind. Pharm 1992; 18: 2207-23.

Malviya Rishabha, Srivastava Pranati, Bansal Mayank, Sharma PK. Preparation and evaluation of disintegrating properties of Cucurbita maxima pulp powder. Int.J.Ph.Sci 2010; 2:395-99.

Mayur V. Chinchore, Sanjay P. Aher, Chetan P. Mahajan, Ghanshyam J. Yadav, Avish. Formulation, optimization and evaluation of mouth dissolving tablet of zidovudine, International Journal of Pharmaceutical Sciences and Business Management. 2014; 07-18.

Mohammed Iqdam Al-Shadeedi, Laith H. Samein, Muayad A. Shehab.Formulation And Evaluation Of Carbimazole Orodispersible Tablet. International Journal Of Pharmacy And Pharmaceutical Sciences.Int J Pharm PharmSci, 2013;5: 232-39

Mohammed BB, Isah, AB, Ibrahim, MA, Influence ofcompaction pressures on modified cassava starch as abinder in paracetamol tablet formulations. Nig J Pharm Sci 2009, 8, 80–8.

Published

07-06-2022

How to Cite

VARGHESE, N., & KOMALA, M. (2022). ANALYSIS OF IN VITRO DISINTEGRATION AND DISSOLUTION EFFECT OF CUCURBITA MAXIMA STARCH IN LOSARTAN FDT. International Journal of Applied Pharmaceutics, 14(4). https://doi.org/10.22159/ijap.2022v14i4.43852

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