• AFRINA AFROSE Queensland University of Technology, Pharmacy Discipline, Faculty of Health, Institute of Health and Biomedical Innovation, Brisbane, QLD, Australia
  • EDWARD T. WHITE School of Chemical Engineering, The University of Queensland, Brisbane, QLD, Australia
  • MD ABDUR RASHID Department of Pharmaceutics, College of Pharmacy, King Khalid University, Guraiger, Abha 62529, Kingdom of Saudi Arabia https://orcid.org/0000-0001-9404-5186
  • TONY HOWES School of Chemical Engineering, The University of Queensland, Brisbane, QLD, Australia
  • YAHYA ALHAMHOOM Department of Pharmaceutics, College of Pharmacy, King Khalid University, Guraiger, Abha 62529, Kingdom of Saudi Arabia https://orcid.org/0000-0002-8368-9047




Ibuprofen, Solubility, Aqueous ethanol, Crystallization, Excipients, UV spectrophotometry


Objective: The objective of this study was to determine the effect of some commonly used pharmaceutical excipients on the solubility of Ibuprofen (Ibu) in a co-solvent consisting of water (W) and ethanol (E). 

Methods: The Ibu solubility studies were carried out by dissolving the drug to equilibrium into aqueous ethanol solvents at a fixed temperature. The temperature of the water bath was kept constant (±0.1 °C of the desired temperatures 10, 25 and 40 °C). The solubility of Ibu was measured by using UV spectrophotometry. 

Results: The low solubility (~ 50 ppm) of Ibu without excipients in water (zero ethanol) was observed. However, Ibu solubility was increased near exponentially with excipient containing co-solvent system. The maximum solubility of Ibu (1726 ppm) was occurred in a co-solvent containing 1.52% leucine, 5.22% mannitol, 0.25% HPMC, 1.55% Pl F127 and 10.75% w/w ethanol. The phase separation between 34% and 63% w/w E/(E+W) was observed at 40 °C. The individual effect of Pl F127 on enhancing the Ibu solubility was significant. 

Conclusion: The individual addition of leucine, mannitol and HPMC has limited impact on the solubility of Ibu. However, the effect of combining these excipients together on Ibu solubility is significantly high.


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How to Cite

AFROSE, A., T. WHITE, E., RASHID, M. A., HOWES, T., & ALHAMHOOM, Y. (2022). TAILORING OF SOLUBILITY OF IBUPROFEN IN THE PRESENCE OF HYDROPHILIC EXCIPIENTS IN WATER-ETHANOL MIXTURES BY CRYSTALLIZATION METHOD. International Journal of Applied Pharmaceutics, 14(2), 102–109. https://doi.org/10.22159/ijap.2022v14i2.43871



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