DETERMINATION OF AURINTRICARBOXYLIC ACID (A VIRAL INHIBITOR) USING MIXED MICELLAR CLOUD POINT EXTRACTION PROCEDURES

Authors

  • RADHA KRIS DIMMITI Department of Physical and Nuclear Chemistry and Chemical Oceanography, School of Chemistry, Andhra University, Visakhapatnam 530003, Andhra Pradesh, India
  • AMEER KHAN SHAIK Department of Physical and Nuclear Chemistry and Chemical Oceanography, School of Chemistry, Andhra University, Visakhapatnam 530003, Andhra Pradesh, India
  • SHYAMALA PULIPAKA Department of Physical and Nuclear Chemistry and Chemical Oceanography, School of Chemistry, Andhra University, Visakhapatnam 530003, Andhra Pradesh, India

DOI:

https://doi.org/10.22159/ijap.2022v14i4.44206

Keywords:

Cloud point extraction (CPE), aurintricarboxylic acid (ATCA), ion-pair, Triton X-114.

Abstract

Objective: Development of micelle mediated cloud point extraction (CPE) and preconcentration of aurintricarboxylic acid (ATCA) (a viral inhibitor).

Methods: The method is based on the ion-pair formation between ATCA and a cationic surfactant tetrabutylammonium bromide (TBAB), which is extracted into the Triton X-114 (TX-114, a non-ionic surfactant) at a pH 4.4. The effect of different important parameters like pH, concentration of surfactants (TX-114 & TBAB), salt, temperature, and time for the extraction of ATCA was optimized.

Results: Extraction efficiency of 90.28 % for CPE of ATCA was obtained using mixed micelles of TX-114 and TBAB. The linear range and limits of detection for ATCA was found to be 8.44 -84.47 µg mL-1 and 8.14 ng mL-1 respectively.

Conclusion: The suggested CPE method has been applied to the determination of ATCA in aqueous solutions.

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References

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Published

14-04-2022

How to Cite

DIMMITI, R. K., SHAIK, A. K., & PULIPAKA, S. (2022). DETERMINATION OF AURINTRICARBOXYLIC ACID (A VIRAL INHIBITOR) USING MIXED MICELLAR CLOUD POINT EXTRACTION PROCEDURES. International Journal of Applied Pharmaceutics, 14(4). https://doi.org/10.22159/ijap.2022v14i4.44206

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Short Communication(s)