DESIGN AND DEVELOPMENT OF SIMVASTATIN LOADED PHARMACOSOMES TO ENHANCE TRANSDERMAL PERMEATION
Keywords:Keywords: Simvastatin, carrier system, transdermal permeation, patches, drug delivery systems, bioavailability.
Objective: The objective of the selected study was to design and formulate simvastatin loaded pharmacosomes and then incorporated into transdermal patch by solvent evaporation technique to enhance the solubility, bioavailability, and half-life of simvastatin.
Methods: Simvastatin comes under the BCS-II class, which has low solubility and high permeability. Simvastain loaded pharmacosomes of six different formulations was prepared by taking simvastatin and soya lecithin in varying ratios and dissolved in a high polarity solvent dichloromethane and then subjected to solvent evaporation method.
Results: Formulated simvastatin loaded pharmacosomes (SLP) were subjected to evaluation, out of six formulation, optimised formulation (F3) shown in-vitro drug release of 86.88%; particle size of 151.6 nm with zeta potential of -16.5mV, which indicates good stability.SEM studies confirmed their smooth porous structure with a number of nano-channels. The FT-IR spectra and DSC showed a stable character of simvastatin in a mixture of lipid and solvent shows compatible and revealed the absence of drug polymer interactions. The SLP was loaded into transdermal patch by solvent evaporation method and evaluated for physical characteristics and results found to be patch surface pH 6.15±0.08, thickness 0.146±0.0096mm, weight uniformity 1.12 ±1.73, % swell-ability 13.50±0.028 for best patch formulation (F3).
Conclusion: This research paper give an outline on significance of simvastatin loaded Pharmacosomes as transdermal patch for enhancing trans-permeation through skin and its characterization and results. Through obtained results it is concluded that pharmacosomes is a promising carrier to enhance permeation of the selected drug through skin.
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