• K. NAVANEETHA Department of Pharmaceutics, Malla Reddy Pharmacy College, Maisammaguda, Secunderabad, Telangana, India
  • V. V. BASAVA RAO University College of Technology, Osmania University, Hyderabad, Telangana, India



ibrutinib, Solubility, L-SNEDDS, Precipitation inhibitor, Magnesium trisilicate


Objective: The aim of current research is to develop a solid supersaturable self-nanoemulsifying drug delivery system (S-SNEDDS) of ibrutinib for enhancing the solubility and dissolution rate.

Methods: Crossential O 94– Croduret 40SS – carbitol are chosen based on the maximum solubility of ibrutinib and were used to construct ternary phase diagrams with Smix in 3:1 ratio and 70 mg drug loading was done and evaluated for particle size, zeta potential, polydispersity index, entrapment efficiency, drug content and in-vitro drug release. To choose a precipitation inhibitor, in-vitro precipitation studies were carried out, and supersaturable SNEDDS were made the prepared formulations were evaluated for micromertitic properties and final optimised one is characterised for FTIR, DSC, SEM and stability studies.

Results: Out of all formulation F15 exhibited good results with highest drug release of 98.25% in 60 min. LSS9 with 3% HPMC E4M as best precipitation inhibitor (PPI) exhibited smallest droplet size of 65.4 nm, a zeta potential of -17.7 mV, and a PDI of 0.453. SSS1 with magnesium trisilicate as an adsorbent showed best flow characteristics and highest drug content of 99.72%. The DSC, FT-IR and stability studies confirmed the complexation of ibrutinib and amorphous state of the drug and formulation to be stable for 3 months.

Conclusion:  Thus, this study indicated that the solid SNEDDS could be used as a potential drug carrier for ibrutinib with improved solubility and dissolution rate.


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How to Cite

NAVANEETHA, K., & RAO, . V. V. B. (2022). FORMULATION AND EVALUATION OF SOLID-SUPERSATURABLE-SNEDDS OF IBRUTINIB. International Journal of Applied Pharmaceutics, 14(5).



Original Article(s)