• JAMAL MOIDEEN MUTHU MOHAMED College of Pharmacy, Shri Indra Ganesan Institute of Medical Science, Manikandam, Tiruchirapalli – 620012, Tamil Nadu, India
  • GAMAL OSMAN ELHASSAN Department of Pharmaceutics, Unaizah College of Pharmacy, Qassim University, Unaizah 51911, Sauadi Arabia
  • JIYAUDDIN KHAN Department of Pharmaceutics, School of Pharmacy, Management and Sciences University. Shah Alam, Selangor, Darul Ehsan, Malaysia
  • R.A.M. JAINAF NACHIYA Crescent School of Pharmacy, BS Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai – 600048, India
  • SAMINATHAN KAYAROHANAM Faculty of Bio-economy and Health Sciences, Geomatika University College Kuala Lumpur 54200, Malaysia
  • ASHOK KUMAR JANAKIRAMAN Faculty of Pharmaceutical Sciences, UCSI University, Cheras 56000, Kuala Lumpur, Malaysia


Pediculosis capitis, Pityrosis capitis, Poly herbal powder, Shampoo, Anti-lice activity


Objective: The main objective of this study was to formulation containing poly herbal medicinal plants, which gives safety, efficacy; rectify the skin disease, scalp disorders and reducing harmful effect from herbal anti-lice and dandruff shampoos for the treatment of Pediculosis capitis and Pityriasis capitis and to prevent hair fall.

Methods: The formulation of herbal shampoo with various herbal ingredients were dried, milled, sieved (120#) and mixed in geometrical order and evaluated their physicochemical characteristics. Furthermore, particle characters, organoleptic properties, foaming index, skin irritation study, and Anti-lice activity were performed. 

Results: The prepared poly herbal powdered shampoo (PHPS) exhibits that was freely soluble, particle 20-25 μm size range and free flowing powder. Lest moisture content (2.5%), ash value, acid value and reduced surface tension of liquid referred as an ideal candidate for foaming, anti-lice potential with no skin irritations.

Conclusion: Based on the evaluation parameters, the prepared powdered shampoo helps to remove hair grease, no hair fall and strengthen hair follicles. Preparation of PHPS formulation at laboratory scale and the compounding of several ingredients of herbal source have produced it possible to ensure safety, efficacy and secure highly effective PHPS.


Download data is not yet available.


Nikam NR, Patil PR, Jadhav RP, Vakhariya RR, Magdum CS. Formulation and Evaluation of Herbal Shampoo: A Comparative Study. Research J. Topical and Cosmetic Sci. 2019; 10(2):61-64. doi: 10.5958/2321-5844.2019.00013.X

Shuster S. The aetiology of dandruff and the mode of action of therapeutic agents. Br J Dermatol. 1984:111(2):235-42. doi: 10.1111/j.1365-2133.1984.tb04050.x. PMID: 6235835.

Mohamed JMM, Alqahtani A, Ahmad F, Krishnaraju V, Kalpana K. Stoichiometrically Governed Curcumin Solid Dispersion and Its Cytotoxic Evaluation on Colorectal Adenocarcinoma Cells. Drug Des Devel Ther. 2020 Nov 2;14:4639-4658. doi: 10.2147/DDDT.S273322. PMID: 33173275; PMCID: PMC7648666.

Victor AD, Prasad M, Mohanasundaram S. Biological active compounds with various medicinal values of Strychnos Nux-vomica – A Pharmacological summary. J Global Trends Pharm Sci. 2016;7(1): 3044-3047.

Jamal Moideen MM, Alqahtani A, Venkatesan K, Ahmad F, Krisharaju K, Gayasuddin M, Shaik RA, Ibraheem KMM, Salama MEM, Abed SY. Application of the Box-Behnken design for the production of soluble curcumin: Skimmed milk powder inclusion complex for improving the treatment of colorectal cancer. Food Sci Nutr. 2020 Oct 30;8(12):6643-6659. doi: 10.1002/fsn3.1957. PMID: 33312548; PMCID: PMC7723192.

Anil K, Ashatha S. Review on Hibiscus rosasinensis, Int. J. Res. Pharm. Biomed. Sci. 2012;3(2):534-538

Mohamed JM, Alqahtani A, Ahmad F, Krishnaraju V, Kalpana K. Pectin co-functionalized dual layered solid lipid nanoparticle made by soluble curcumin for the targeted potential treatment of colorectal cancer. Carbohydr Polym. 2021 Jan 15;252:117180. doi: 10.1016/j.carbpol.2020.117180. Epub 2020 Oct 7. PMID: 33183627.

Jaishetty N, Kamaraj P, Arthanareeswari M. Enantiometric Separation Of Sitagliptin In A Fixed Dose Combination Formula Of Sitagliptin And Metformin By A Chiral Liquid Chromatographic Method. Int J Pharm Pharm Sci. 2019;11(6):66-71.

Jaishetty N, Palanisamy K, Maruthapillai A, Jaishetty R. Trace Level Quantification of the (-)2-(2-amino-5-chlorophenyl)-4-cyclopropyl-1,1,1-trifluoro-3-butyn-2-ol Genotoxic Impurity in Efavirenz Drug Substance and Drug Product Using LC-MS/MS. Sci Pharm. 2015 Oct 18;84(3):456-466. doi: 10.3390/scipharm84030456. PMID: 28117312; PMCID: PMC5064237.

Bharathi P, Elavarasi N, Mohanasundaram S. Studies on rate of Biodegradation of Vegetable oil (Cocunut oil) by using Pseudomonas sp. International Journal of Environmental Biology. 2012; 2(2):12-19.

Mohamed JMM, Alqahtani A, Al Fatease A, Alqahtani T, Khan BA, Ashmitha B, Vijaya R. Human Hair Keratin Composite Scaffold: Characterisation and Biocompatibility Study on NIH 3T3 Fibroblast Cells. Pharmaceuticals (Basel). 2021 Aug 9;14(8):781. doi: 10.3390/ph14080781. PMID: 34451878; PMCID: PMC8401710.

Narendhiran S, Mohanasundaram S, Arun J, Saravanan L, Catherine L, Subathra M, Rannjith RV, Prasanna, Alagesan, Buvaneshwri. Comparative study in larvicidal efficacy of medicinal plant extracts against Culex quinquefasciatus. International Journal of Research in Plant Science. 2014;4(1): 22-25.

Mohamed JMM, Alqahtani A, Khan BA, Al Fatease A, Alqahtani T, Venkatesan K, Ahmad F, Alzghoul BI, Alamri A. Preparation of Soluble Complex of Curcumin for the Potential Antagonistic Effects on Human Colorectal Adenocarcinoma Cells. Pharmaceuticals (Basel). 2021 Sep 19;14(9):939. doi: 10.3390/ph14090939. PMID: 34577638; PMCID: PMC8467777.

Mohanasundaram S, Victor AD, Prasad M, Magesh R, Sivakumar K and Subathra M. Pharmacological analysis of hydroethanolic extract of Senna alata (L.) for in vitro free radical scavenging and cytotoxic activities against HepG2 cancer cell line. Pak. J. Pharm. Sci. 2019;32(3):931-934.

Mohamed JMM, Ahmad F, Alqahtani A, Alqahtani T, Raju VK, Anusuya M. Studies on Preparation and Evaluation of Soluble 1:1 Stoichiometric Curcumin Complex for Colorectal Cancer Treatment. Trends in Science. 2021;18(24):1403. doi:

Nille GC, Mishra SK, Chaudhary AK, Reddy KRC. Ethnopharmacological, Phytochemical, Pharmacological, and Toxicological Review on Senna auriculata (L.) Roxb.: A Special Insight to Antidiabetic Property. Front Pharmacol. 2021 Aug 24;12:647887. doi: 10.3389/fphar.2021.647887. PMID: 34504420; PMCID: PMC8423098.

Mohanasundaram S, Rangarajan N, Sampath V, Porkodi K, Prakash MVD, Monicka N. GC-MS Identification of Anti-inflammatory and Anticancer Metabolites in Edible Milky White Mushroom (Calocybe indica) against Human Breast Cancer (MCF-7) Cells. Res J Pharm and Tech.2021;14(8):4300-4306.

Mohamed JM, Ahmad F, Kishore N, Al-Subaie AM. Soluble 1: 1 stoichiometry curcumin binary complex for potential apoptosis in human colorectal adenocarcinoma cells (SW480 and Caco-2 cells). Res. J. Pharm. Tech. 2021;14 (1):129-135.

Kumar JA, Ramkanth S, Prabu LS, Gopal V. Enhancement of saturation solubility and in vitro dissolution of carvedilol nanoparticles by high pressure homogenization technique. Int. J. Curr. Pharm. Rev. Res. 2015;6(6):269-273.

Raffick MM, Mohamed JM, Vetriselvan S, Vignesh M, Selvakumar K, Parkavi V, Ruby JJ. Preparation and evaluation of in-vitro release kinetics of novel bilayer metoprolol succinate as sustained release and amlodipine besylate as immediat release tablets. Int. J. Biol. Pharm. Res. 2012; 3(2): 285-297.

Mohanasundaram S, Rangarajan N, Sampath V, Porkodi K, Pennarasi M. GC-MS and HPLC analysis of Antiglycogenolytic and Glycogenic compounds in Kaempferol 3–O–gentiobioside containing Senna alata L leaves in experimental rats. Translational Metabolic Syndrome Research. 2021;4:10-17.

Halith SM, Abirami A, Jayaprakash S, Chitra K, Pillai KK, Firthouse PU. Effects of Ocimum sanctum and Azadiracta indica on the formulation of anti-dandruff herbal shampoo powder. Der Pharm Lett. 2009:1(2):68-76

Janakiraman AK, Sumathi B, Saleem TM, Ramkanth S, Kumar PO, Venkatachalam G. Design and evaluation of carvedilol nanocrystals sustained release tablets. J Appl Pharm Sci. 2017;7(4):61-68.

Victor AD, Mohanasundaram S, Prasad M. Analysis of hydroethanolic extract of Senna alata (L.) to screen bioactive compounds with inhibitory activity on lipid peroxidation, in vitro antibacterial and antidiabetic efficacy. Int J Pharma Sci. 2016;6(1): 1360-1366.

Mainkar AR, Jolly CI. Evaluation of commercial herbal shampoos. Int J Cosmet Sci. 2000 Oct;22(5):385-91. doi: 10.1046/j.1467-2494.2000.00047.x. PMID: 18503425.

Mohamed JM, Bharathidasan P, Raffick MM. Preformulation and development of curcumin magnetic nanosuspension using magnetite (Fe3O4) and methyl cellulose. Int J Pharma Bio. Sci. 2012;3(4):419-432.

Vasudevan K, Krishnapriya AS, Vijay VV, Thasny PPS. Formulation, Evaluation, and Comparison of Poly Herbal Shampoo with the Commercial Herbal Shampoos. Int. J. Pharm. Res. Appl. 2021;6(1):137-145. doi: 10.35629/7781-0601137145

AlQuadeib BT, Eltahir EKD, Banafa RA, Al-Hadhairi LA. Pharmaceutical evaluation of different shampoo brands in local Saudi market. Saudi Pharm J. 2018 Jan;26(1):98-106. doi: 10.1016/j.jsps.2017.10.006. Epub 2017 Oct 6. PMID: 29379340; PMCID: PMC5783807.

Rassami W, Soonwera M. In vitro pediculicidal activity of herbal shampoo base on Thai local plants against head louse (Pediculus humanus capitis De Geer). Parasitol Res. 2013 Apr;112(4):1411-6. doi: 10.1007/s00436-013-3292-8. Epub 2013 Jan 20. PMID: 23334727.

Mohamed JMM, Alqahtani A, Kumar TVA, Fatease AA, Alqahtani T, Krishnaraju V, Ahmad F, Menaa F, Alamri A, Muthumani R, Vijaya R. Superfast Synthesis of Stabilized Silver Nanoparticles Using Aqueous Allium sativum (Garlic) Extract and Isoniazid Hydrazide Conjugates: Molecular Docking and In-Vitro Characterizations. Molecules. 2021 Dec 24;27(1):110. doi: 10.3390/molecules27010110. PMID: 35011342; PMCID: PMC8746848.



How to Cite




Original Article(s)

Most read articles by the same author(s)