• PRADEEP KOPPOLU Faculty of Dentistry, Lincoln University College, Malaysia
  • RASHEED ABDULSALAM Faculty of Dentistry, Lincoln University College, Malaysia


NLRP3, Inflammasome, Innate immunity


Periodontitis disease is the most condition caused by the inflammatory response in the periodontal tissue. It is well known and established that alone the presence of pathogenic bacteria is insufficient in causing periodontitis disease. Immune response and pathways play a key role in development of lesions and hence it is necessary to understand the same to assess on how the disease is progressing. Further, it is observed that a comprehensive immune response is initiated in cases with periodontal disease. It is essential to summarize the mechanisms of the immune system involved in periodontal disease. Hence, to understand the immune mechanism and pathways that are also contributory factors for the progression of the disease, a database search is conducted with the keywords and two research articles are shortlisted and reviewed in this review article.


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Cugini C, Ramasubbu N, Tsiagbe VK, Fine DH. Dysbiosis From a Microbial and Host Perspective Relative to Oral Health and Disease. Front Microbiol. 2021 Mar 5;12:617485. doi: 10.3389/fmicb.2021.617485. PMID: 33763040; PMCID: PMC7982844.

Kumar VBNa, Arvina R, Sivaranjani S, Hema P, Arun Varghese R. Role of Immunology in Periodontal Disease: A Brief Review. J Sci Dent. 2018;8(2):25-28.

Cekici A, Kantarci A, Hasturk H, Van Dyke TE. Inflammatory and immune pathways in the pathogenesis of periodontal disease. Periodontol 2000. 2014 Feb;64(1):57-80. doi: 10.1111/prd.12002. PMID: 24320956; PMCID: PMC4500791.

Kumar M, Mishra L, Panda S, Satpathy A, Das AC, Mohanty G. Immune Regulation in Periodontal Disease: A Review. Indian J Forensic Med Toxicol. 2020;14(4): 8124–8127

Mariano FS, Cássia J, Sardi O, Duque C. The role of immune system in the development of periodontal disease: a brief review. Rev. odontociênc. 2010;25(3):300-305.

Hirschfeld J. Neutrophil Subsets in Periodontal Health and Disease: A Mini Review. Front Immunol. 2020 Jan 8;10:3001. doi: 10.3389/fimmu.2019.03001. PMID: 31998301; PMCID: PMC6961529.

Cueno ME, Ochiai K. Gingival Periodontal Disease (PD) Level-Butyric Acid Affects the Systemic Blood and Brain Organ: Insights Into the Systemic Inflammation of Periodontal Disease. Front Immunol. 2018 Jun 4;9:1158. doi: 10.3389/fimmu.2018.01158. PMID: 29915575; PMCID: PMC5994410.



How to Cite

KOPPOLU, P., & ABDULSALAM, R. (2022). ROLE OF INNATE IMMUNITY IN PERIODONTAL DISEASE: A BRIEF UPDATE. International Journal of Applied Pharmaceutics, 14. Retrieved from



Review Article(s)