In-vitro anticancer, antioxidant and molecular docking studies of 4-aminobenzamide metal complexes

Authors

  • S. NARASIMHAVARMAN PG& Research Department of Chemistry, Govt. Arts College, Ariyalur-621713, Tamil Nadu, (Affiliated to Bharathidasan University, Tiruchirappalli-620024), India
  • K. RAJASEKAR PG& Research Department of Chemistry, Govt. Arts College, Ariyalur-621713, Tamil Nadu, (Affiliated to Bharathidasan University, Tiruchirappalli-620024), India
  • SUDIP KUMAR MANDAL Department of Medicinal Chemistry, Dr. B.C. Roy College of Pharmacy and A.H.S, Durgapur, West Bengal-713206, India
  • R. SELVARANI PG& Research Department of Chemistry, Govt. Arts College, Ariyalur-621713, Tamil Nadu, (Affiliated to Bharathidasan University, Tiruchirappalli-620024), India
  • C. VEERAVEL PG& Research Department of Chemistry, Govt. Arts College, Ariyalur-621713, Tamil Nadu, (Affiliated to Bharathidasan University, Tiruchirappalli-620024), India

Keywords:

4-aminobenzamide, antibacterial, antifungal, anticancer, antioxidant, molecular docking

Abstract

Introduction
Mixed ligand complexes of Cu(II) and Cd(II) with 4-aminobenzamide(4-ABZ) have been synthesized under microwave irradiation and they were characterized by elemental analysis, estimation of metal ion, molar conductivity, magnetic study, FT-IR, Far-IR, electronic spectra, NMR (1H & 13C) and EPR spectral studies.
Methodology
The data of microanalysis and metal estimation showed that the complexes have the composition of [M(L1)2(L2)2] for Cu(II) & [M(L1)(L2)2] for Cd(II) complex respectively. The conductivity data confirmed the neutral nature of the complexes. The tetrahedral geometry of the Cd(II) complex was confirmed using UV-Visible spectra. The tetragonally distorted octahedral stereochemistry of Cu(II) complex was further confirmed by UV and EPR spectral studies. The diamagnetic nature and probable geometry of Cd(II) complex were also confirmed using NMR spectral studies which are also compared with free 4-aminobenzamide. The in-vitro bio-potential activities of 4-ABA and Cd(II) complex were screened for E. coli and C. Albicans microorganisms by Agar disc diffusion methods.
Results and Conclusion
The cancer study of Cu(II) complex and antioxidant activity of DPPH free radical scavenging method of Cd(II) complex were measured and compared with 4-aminobenzamide and standard drugs. The breast cancer studies were also identified using the targeted proteins viz., BRCA1, PR & EGFR by molecular docking study.

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References

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Published

21-06-2022

How to Cite

NARASIMHAVARMAN, S., RAJASEKAR, K., MANDAL, S. K., SELVARANI, R., & VEERAVEL, C. (2022). In-vitro anticancer, antioxidant and molecular docking studies of 4-aminobenzamide metal complexes . International Journal of Applied Pharmaceutics, 14. Retrieved from https://innovareacademics.in/journals/index.php/ijap/article/view/45557

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