A COMPARATIVE STUDY OF QUALITY CONTROL TESTING OF MEFENAMIC ACID TABLETS IN IRAQ

Authors

DOI:

https://doi.org/10.22159/ijap.2022v14i6.46251

Keywords:

Mefenamic acid, Quality test, Oral dosage form

Abstract

Objective: This research was performed to assess the quality of different marketed tablets having mefenamic acid (500 mg). The selected tablets are produced by numerous companies and presented in the Iraqi pharmaceutical marketplace.

Methods: Different batches of mefenamic acid conventional tablets were exposed for several tests of quality control. These evaluation tests include hardness, weight variation, friability, disintegration time, drug content, and drug dissolution profile. The properties of these quality tests were made conferring to the specification of USP-pharmacopeia.

Results: The data of this study indicate that each tablet of mefenamic acid batches conformed to the requirement of USP pharmacopeia, the hardness was (6.87-8.06 Kg/cm2), and the drug content results were (90.666-99.214%) within USP limitation. The data of disintegration time and weight uniformity were agreeable with pharmacopeia and the in vitro release assay showed that the release of each mefenamic acid marketed tablet was highest than (80 %) in 45 min, which reproducing compliance with the USP pharmacopeia's limitation.

Conclusion: From this study, it was proved that all of the marketed brands of mefenamic acid tablets meet the standard character in the USP pharmacopeia for in vitro quality control tests.

Downloads

Download data is not yet available.

References

Xhafaj D, Malaj L, Mileti M. A comparative quality control study of cetirizine hydrochloride 10 mg tablets on the Albanian pharmaceutical market. Int J Pharm Pharm Sci. 2015;7(1):504-7.

Hasan A, Dewan SA, Ahamed SK, Kai MM. Quality control studies on cetirizine hydrochloride tablets available in Bangladesh drug market. Int J Pharm Biol Sci. 2013;3(1):349-54.

Remington HS. The Sci Pract Pharm, volume I and volume II. 22nd ed. J Med Libr Assoc. 2014 Jul;102(3):220-1.

PubChem. Bethesda: National Library of Medicine; 2004-. PubChem Compound Summary for CID 4044, Mefenamic acid. National Center for Biotechnology Information. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Mefenamic-acid. [Last accessed on 20 Aug 2022]

Daraji NK, Patel VP, Ramani VD. Formulation optimization and characterization of aqueous injection containing poorly soluble drug using mixed hydrotropic solubilization. Int J Curr Pharm Sci. 2021;13(5):100-7. doi: 10.22159/ijcpr.2021v13i5.1908.

Majeed SM, Al-Shaheen K, Al-Zidan RN. Quality control study on Conventional metronidazole tablets available in the Iraqi market. Res J Pharm Technol. 2021;14(2):803-8. doi: 10.5958/0974-360X.2021.00141.4.

Moffat AC, Osselton MD, Widdop B. Clark’s analysis of drugs and poisons. 4th ed. London: Pharmaceutical Press; 2011. p. 1617.

Gupta MM, Gupta M. Comparative pharmaceutical quality control testing of different brands of paracetamol tablets available in Trinidad and Tobago, West Indies. Int J Pharm Sci Res. 2016;7(7):2830-6.

Ramakrishna S, Mihira V, Raja Vyshnavi K, Ranjith V. Design and evaluation of drug release kinetics of meloxicam sustained release matrix tablets. Int J Curr Pharm Res. 2012;4:90-9.

Uddin MS, Mamun AA, Tasnu T, Asaduzzaman M. In-process and finished products quality control tests for pharmaceutical tablets according to pharmacopoeias. J Chem Pharm Res. 2015;7(9):180-5.

Shah MR, Nasiri MI, Anwer S, Ali T, Zaheer K, Ahmed K. Pharmaceutical quality assessment of different brands of moxifloxacin 400 mg tablets available in Pakistan. RADS. J Pharm Pharm Sci. 2019;7(1):2-8.

Raza A. Spectrophotometric determination of mefenamic acid in pharmaceutical preparations. J Anal Chem. 2008;63(3):244-7. doi: 10.1134/S106193480803009X.

Kumar S, Parkash C, Kumar P, Singh SK. Application of some novel techniques for solubility enhancement of mefenamic acid, A poorly water-soluble drug. Int J Pharm Sci Drug Res. 2009;1(3):164-71.

Seetha Lekshmi S, Guru Row TN. Conformational polymorphism in a non-steroidal anti-inflammatory drug, mefenamic acid. Cryst Growth Des. 2012;12(8):4283-9. doi: 10.1021/cg300812v.

The United States Pharmacopeia. USP30-NF25. Convention Inc Rockville MD General tests and assays CD; 2007.

Neamah AJ, Hasan A-GKM, Talib Khudhair AHK. Design and characterization of candesartan cilexetil oral nanoemulsion containing garlic oil. Int J Appl Pharm. 2019;6:116-24.

Parrot EL, Saski W. Solid pharmaceuticals. In: Experimental pharmaceutical technology. 3rd ed. Minneapolis: Burgess Publishing Co; 1971. p. 58-106.

Aulton ME, Taylor K. Aulton’s pharmaceutics the design and manufacture of medicines. 4th ed. New York: Churchill livingstone Elsevier; 2013.

Lachman L, Lieberman HA, Kanig JL. Theory and practice of industrial pharmacy. New Delhi: CBS Publishers and Distributors Pvt, Ltd; 2009. p. 229-345.

Abbas SS, Hassan F, Naveed S, Qamar F, Hameed A. Pharmaceutical equivalent study of mefenamic acid formulation available in Karachi, Pakistan. RADS-JPPS. 2015;3(2):113-6.

Satish NP, Satish KN. Design and optimization of fast-dissolving tablets containing metoprolol by sublimation method. Int Res J Pharm. 2010;1(1):346-57.

Zafar F, Ali H, Shah NS, Naveed S, Siddiqui S. Quality assessment and dissolution profile comparison studies on 250 mg mefenamic acid tablets available in the local market of Karachi. J Chin Pharm Sci. 2015;24(10):673-7.

Published

07-11-2022

How to Cite

ABDULRAZZAQ, I. F., SALAL, Y. A., ABDUL-HASAN, M. T., ABBAS, H. K., & HASAN AL-GBURI, K. M. (2022). A COMPARATIVE STUDY OF QUALITY CONTROL TESTING OF MEFENAMIC ACID TABLETS IN IRAQ. International Journal of Applied Pharmaceutics, 14(6), 127–130. https://doi.org/10.22159/ijap.2022v14i6.46251

Issue

Section

Original Article(s)

Most read articles by the same author(s)