MECHANISM OF ACTION, SYNTHESIS, PROPERTIES AND ANALYTICAL METHODS OF CABOZANTINIB

DETERMINATION OF CABOZANTINIB

Authors

  • AKANKSHA DWIVEDI Acropolis Institute of Pharmaceutical Education and Research, Indore, MP, 2KIET Group of Institutions (KIET School of Pharmacy), Delhi-NCR, Meerut Road (NH-58), Ghaziabad 201206
  • RAKHI KHABIYA Acropolis Institute of Pharmaceutical Education and Research, Indore, MP, 2KIET Group of Institutions (KIET School of Pharmacy), Delhi-NCR, Meerut Road (NH-58), Ghaziabad 201206
  • ALANKAR SHRIVASTAVA Acropolis Institute of Pharmaceutical Education and Research, Indore, MP, 2KIET Group of Institutions (KIET School of Pharmacy), Delhi-NCR, Meerut Road (NH-58), Ghaziabad 201206 https://orcid.org/0000-0003-3284-0445
  • SIDDHARTH TYAGI Acropolis Institute of Pharmaceutical Education and Research, Indore, MP, 2KIET Group of Institutions (KIET School of Pharmacy), Delhi-NCR, Meerut Road (NH-58), Ghaziabad 201206
  • KANDASAMY NAGARAJAN Acropolis Institute of Pharmaceutical Education and Research, Indore, MP, 2KIET Group of Institutions (KIET School of Pharmacy), Delhi-NCR, Meerut Road (NH-58), Ghaziabad 201206
  • G. N. DARWHEKAR Acropolis Institute of Pharmaceutical Education and Research, Indore, MP, 2KIET Group of Institutions (KIET School of Pharmacy), Delhi-NCR, Meerut Road (NH-58), Ghaziabad 201206

DOI:

https://doi.org/10.22159/ijap.2023v15i1.46409

Keywords:

Cabozantinib, cancer, analytical methods, spectrophotometry, chromatography

Abstract

Globally, the burden of cancer is substantial and growing. The impact of burden of such diseases over the society is unpredictable in terms of health lost and cost. Unfortunately, the estimates shown the burden may be increasing in upcoming decades. Cabozantinib (CBZ) is newly developed tyrosin kinase inhibitor (TKI) for Differentiated thyroid cancer (DTC), Hepatic Cellular Carcinoma (HCC), Medullary thyroid cancer (MTC) and Renal Cell Carcinoma (RCC). The objective of presented review is to provide updated knowledge of drug especially covering analytical methodologies. The review covered introduction, mechanism of action, pharmacokinetics, synthesis and developed analytical methods by various researchers. The review covered one spectrophotometry and about twenty chromatography methods. The review will be helpful for the scientist working in this area and especially helpful for analytical scientists exploring new analytical methodologies for CBZ.

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References

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Published

21-10-2022

How to Cite

DWIVEDI, A., KHABIYA, R., SHRIVASTAVA, A., TYAGI, S., NAGARAJAN, K., & DARWHEKAR, G. N. (2022). MECHANISM OF ACTION, SYNTHESIS, PROPERTIES AND ANALYTICAL METHODS OF CABOZANTINIB: DETERMINATION OF CABOZANTINIB. International Journal of Applied Pharmaceutics, 15(1). https://doi.org/10.22159/ijap.2023v15i1.46409

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Review Article(s)