FORMULATION OF NANOEMULGEL CONTAINING EXTRACT OF IMPATIENTS BALSAMINA L. AND ITS ANTIBACTERIAL ACTIVITY

ERINDYAH RETNO WIKANTYASNING; GUNAWAN SETIYADI; RATIH PRAMUNINGTYAS; MEGA DWI KURNIAWATI; CHAI YEE HO

doi:10.22159/ijap.2023v15i3.46670

Authors

ERINDYAH RETNO WIKANTYASNING Department of Pharmaceutics, Faculty of Pharmacy, Universitas Muhammadiyah Surakarta, Surakarta, 57169, Indonesia https://orcid.org/0000-0002-8997-7322
GUNAWAN SETIYADI Department of Pharmaceutics, Faculty of Pharmacy, Universitas Muhammadiyah Surakarta, Surakarta, 57169, Indonesia https://orcid.org/0000-0002-6881-687X
RATIH PRAMUNINGTYAS Faculty of Medical, Universitas Muhammadiyah Surakarta, Surakarta, 57169, Indonesia
MEGA DWI KURNIAWATI Department of Pharmaceutics, Faculty of Pharmacy, Universitas Muhammadiyah Surakarta, Surakarta, 57169, Indonesia
CHAI YEE HO Chemical Engineering Department, Universiti Teknologi PETRONAS, 32610 Seri Iskandar, Perak Darul Ridzuan, Malaysia

DOI:

https://doi.org/10.22159/ijap.2023v15i3.46670

Keywords:

Nanoemulgel, Gelling agent, Impatients balsamina, L., Optimization, Formulation

Abstract

Objective: This study aimed to optimize the nanoemulgel formulation for balsam leaves (Impatients balsamina L.) extract and determine its antibacterial activity.

Methods: Balsam leaves were extracted using the maceration method using ethanol. The nanoemulsion of balsam leaves ethanol extract was prepared with various oil, surfactants, and co-surfactant concentrations. Characterization was conducted on the nanoemulsion formed, including transmittance, droplet size, polydispersity index, and zeta potential. The chosen nanoemulsion formula was then transformed into a gel preparation using various gelling agent concentrations, i.e., Carbopol 940 and chitosan, and optimized using the Design-Expert v13 software with the simplex lattice design method.

Results: The study discovered the optimum nanoemulgel formula with a desirability value of 0.859. The ratio of Carbopol 940 with chitosan was 1.38% and 0.12%w/w, respectively, with an antibacterial activity inhibition zone against S. epidermidis of 22±2 mm in diameter.

Conclusion: The observed responses closely matched the predicted values provided by the optimization method. The optimized nanoemulgel formulation has the potential to develop as an antibacterial dosage form.

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