FORMULATION OF NANOSTRUCTURED LIPID CARRIERS OF HALOPERIDOL PREPARED BY USING CLARIFIED BUTTER

Authors

  • SHARWAREE RAJAN HARDIKAR Department of Pharmaceutics, MCES’s Allana College of Pharmacy, Pune https://orcid.org/0000-0003-4585-5320
  • DANIYAL MOHD AKBAR ANSARI Department of Pharmaceutics, MCES’s Allana College of Pharmacy, Pune https://orcid.org/0000-0003-4654-3441
  • NILESH ANIL PATIL Department of Pharmaceutics, MCES’s Allana College of Pharmacy, Pune

DOI:

https://doi.org/10.22159/ijap.2023v15i2.46759

Keywords:

Haloperidol, Clarified butter, Nano-structured lipid carriers, factorial design

Abstract

Objective: To develop the nanostructured lipid carriers (NLC’s) using clarified butter. 

Methods: Haloperidol loaded micro emulsion templates were prepared by using Smix of Tween 80 and propylene glycol in the ratio 1:2. The selection of the mixture of surfactant and co-surfactant (Smix) and their appropriate proportion were decided by the traditional way of construction of pseudo ternary phase diagrams. 22 factorial design was used to check the amenability of the formulation for its successful scale-up. Sonication time and the amount of Smix were selected as independent variables and their influence on the globular size (Y1) of the micro emulsions formed was evaluated by using statistical models. Composition of optimized micro emulsion template was further used to prepare haloperidol loaded NLC’s by ‘micro emulsion quenching method’.

Results: The micro emulsion formulations containing Tween 80 as a surfactant and propylene glycol as a co-surfactant exhibited the smallest globular size and hence this composition was used further to implement factorial design as design of experiments.  The statistical analysis of the data suggested that the micro emulsion formulation can be scaled up successfully. NLC’s were prepared from the optimized micro emulsion formulation as template. The globular size of NLC’s was confirmed by Transmission Electron Microscopy and was observed to be in the range of 300 to 600 nm.

Conclusion: The present work suggested that the latency of the clarified butter as a natural blend of solid lipid and liquid lipids can be successfully explored to prepare nanostructured lipid carriers.

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Published

29-12-2022

How to Cite

HARDIKAR, S. R., AKBAR ANSARI, D. M., & PATIL, N. A. (2022). FORMULATION OF NANOSTRUCTURED LIPID CARRIERS OF HALOPERIDOL PREPARED BY USING CLARIFIED BUTTER. International Journal of Applied Pharmaceutics, 15(2). https://doi.org/10.22159/ijap.2023v15i2.46759

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