FORMULATION OF NANOSTRUCTURED LIPID CARRIERS OF HALOPERIDOL PREPARED BY USING CLARIFIED BUTTER
Keywords:Haloperidol, Clarified butter, Nano-structured lipid carriers, factorial design
Objective: To develop the nanostructured lipid carriers (NLC’s) using clarified butter.
Methods: Haloperidol loaded micro emulsion templates were prepared by using Smix of Tween 80 and propylene glycol in the ratio 1:2. The selection of the mixture of surfactant and co-surfactant (Smix) and their appropriate proportion were decided by the traditional way of construction of pseudo ternary phase diagrams. 22 factorial design was used to check the amenability of the formulation for its successful scale-up. Sonication time and the amount of Smix were selected as independent variables and their influence on the globular size (Y1) of the micro emulsions formed was evaluated by using statistical models. Composition of optimized micro emulsion template was further used to prepare haloperidol loaded NLC’s by ‘micro emulsion quenching method’.
Results: The micro emulsion formulations containing Tween 80 as a surfactant and propylene glycol as a co-surfactant exhibited the smallest globular size and hence this composition was used further to implement factorial design as design of experiments. The statistical analysis of the data suggested that the micro emulsion formulation can be scaled up successfully. NLC’s were prepared from the optimized micro emulsion formulation as template. The globular size of NLC’s was confirmed by Transmission Electron Microscopy and was observed to be in the range of 300 to 600 nm.Conclusion: The present work suggested that the latency of the clarified butter as a natural blend of solid lipid and liquid lipids can be successfully explored to prepare nanostructured lipid carriers.
Franciska E, Luca AB, Dániel F, Agnes BA, Sveinbjorn G. Evaluation of intranasal delivery route of drug administration for brain targeting. Brain Res Bull. 2018 Oct;143:155-70. https://doi.org/10.1016/j.brainresbull.2018.10.009
Giulio S, Gabriele R. Antipsychotic-Induced Metabolic and Cardiovascular Side Effects in Schizophrenia: A Novel Mechanistic Hypothesis. CNS Drugs. 2013 Mar;27:249–57. https://doi.org/10.1007/s40263-013-0054-1
Singh R, Bansal Y, Medhi B, Kuhad A. Antipsychotic-induced metabolic alterations: recounting the mechanistic insights, therapeutic targets and pharmacological alternatives. Eur J Pharmacol. 2019 Feb 5; 844:231-40. DOI: 10.1016/j.ejphar.2018.12.003
Patricia PM, Hugh DCS, Zhengrong C. Strategies to facilitate or block nose-to- brain drug delivery. Int J Pharm. 2019 Oct 30;570:118635. DOI: 10.1016/j.ijpharm.2019.118635
Salvi VR, Pawar P. Nanostructured lipid carriers (NLC) system: A novel drug targeting carrier. J Drug Deliv Sci Tec. 2019 Jun;51:255-67. https://doi.org/10.1016/j.jddst.2019.02.017
Shevalkar G, Vavia P. Solidified nanostructured lipid carrier (S-NLC) for enhancing the oral bioavailability of ezetimibe. J Drug Deliv Sci Tec. 2019 Oct;53:111211. https://doi.org/10.1016/j.jddst.2019.101211
Lígia NMR, Márcia CB, Viviane AG, Gustavo HR da Silva, Verônica MC, Simone RC, Bárbara OP, Daisy M, Eneida P. Natural lipids-based NLC containing lidocaine: From pre-formulation to in vivo studies. Eur J Pharm Sci. 2017 Aug 30;106:102-12. doi: 10.1016/j.ejps.2017.05.060.
Khunt D, Shah B, Misra M. Role of butter oil in brain targeted delivery of Quetiapine fumarate microemulsion via intranasal route. J Drug Deliv Sci Tech. 2017 May;40:11-20. DOI:10.1016/j.jddst.2017.05.004
Mortensen BK. Anhydrous Milk Fat/Butter Oil and Ghee. Enc Dai Sci. 2016;515-21. https://doi.org/10.1016/B978-0-08-100596-5.00647-8
Fardin T, Mohammad S, Jaleh V, Ali N. Nanostructured lipid carriers (NLC): A potential delivery system for bioactive food molecules. Innov Food Sci Emerg. 2013 July;19:29-43. https://doi.org/10.1016/j.ifset.2013.03.002
Slavomira D, Ranjita S, Eliana BS. Nanostructures for novel therapy.1st ed. Philadelphia, United States; 2017. 811p. https://www.elsevier.com/books/nanostructures-for-novel-therapy/ficai/978-0-323-46142-9
Hamed AS, Azza AM, Amany OK, Mayssa AH, Gehanne ASA. Phospholipid based colloidal poloxamer–nanocubic vesicles for brain targeting via the nasal route. Colloid Surface B. 2012 Dec 1;100:146-54. doi: 10.1016/j.colsurfb.2012.05.010.
Bhavbhuti MM. Gourmet and Health Promoting specialty oils. 1sted. AOCS Press; 2009. 527p.
Antony J. Design of Experiments for Engineers and Scientists. 2nd ed. Elsevier;2014. 63p. https://doi.org/10.1016/B978-0-7506-4709-0.X5000-5
Joshi M, Patravale V. Formulation and Evaluation of Nanostructured Lipid Carrier (NLC)–based Gel of Valdecoxib. Drug Dev Ind Pharm. 2006 Sept;32(8):911-18. https://doi.org/10.1080/03639040600814676
Lawrence MJ, Rees GD. Microemulsion-based media as novel drug delivery systems. Adv Drug Deliv Rev. 2000 Dec 6;45(1):89-121. doi: 10.1016/s0169-409x(00)00103-4.
Khatri P, Shao J. Mechanism and Structural Factors of Lipid and Surfactant in the Formation of Self Emulsified Nano-emulsion. J Pharm Sci.2018 Aug;107(8):2198-2207. https://doi.org/10.1016/j.xphs.2018.03.024
Kreuter J. Nanoparticulate systems for brain delivery of drugs. Adv Drug Deliv Rev. 2012 Dec;64,213-22. https://doi.org/10.1016/j.addr.2012.09.015
Kreuter J. Drug delivery to the central nervous system by polymeric nanoparticles: what do we know? Adv Drug Deliv Rev. 2014 May;71:2-14. https://doi.org/10.1016/j.addr.2013.08.008
Joshi M, Patravale V. Nanostructured lipid carrier (NLC) based gel of celecoxib. Int J Pharm. 2008 Jan; 346(1-2):124–32. https://doi.org/10.1016/j.ijpharm.2007.05.060
Karuppusami G, Gandhinathan R. Pareto analysis of critical success factors of total quality management: A literature review and analysis. TQM Mag. 2006 Jul;18(4):372-85. https://doi.org/10.1108/09544780610671048
Danaei M, Dehghankhold M, Ataei S, Hasanzadeh DF, Javanmard R, Dokhani A, Khorasani S, Mozafari MR. Impact of Particle Size and Polydispersity Index on the Clinical Applications of Lipidic Nanocarrier Systems. Pharmaceutics. 2018 May 18;10(2):57. doi: 10.3390/pharmaceutics10020057.
Ell-Assal MI, Samuel D. Optimization of rivastigmine chitosan nanoparticles for neurodegenerative alzheimer; in vitro and ex vivo characterizations.Int j Pharm Pharm Sci. 2021:14(1):17-27. DOI:10.22159/ijpps.2022v14i1.43145
Kumar B, Garg V, Singh A, Pandey NK, Singh S,Panchal S, et al. Investigation and optimization of formulation parameters for self-nanoemulsifying delivery system of two lipophilic and gastrointestinal labile drugs using box-behnken design. Asian J Pharm Clin Res. 2018;11(2):12-8. DOI:10.22159/ajpcr.2018.v11s2.28585
Mojahedian MM, Daneshamouz S, Samani SM, Zargaran A. A novel method to produce solid lipid nanoparticles using n-butanol as an additional co-surfactant according to the o/w microemulsion quenching technique. Chem Phys Lipids. 2013 Sept;174:32-8. https://doi.org/10.1016/j.chemphyslip.2013.05.001
Caboi F, Lazzari P, Pani L, Monduzzi M. Effect of 1-butanol on the microstructure of lecithin/water/tripalmitin system. Chem Phys Lipids. 2005 Jun;135(2):147–56. https://doi.org/10.1016/j.chemphyslip.2005.02.010
Mohammed E, Mohammad M. Nanostructured lipid carriers (NLCs) as drug delivery (NLCs) as drug delivery platform: Advances in formulation and delivery strategies. Saudi. Pharm. J. 2021Sep;29(9): 999- 1012. https://doi.org/10.1016/j.jsps.2021.07.015
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