• AGUSTIN NININTOWE T. SANTO Oral Medicine Residency Program, Faculty of Dentistry, Universitas Padjadjaran, Jl. Sekeloa Selatan No. 1, Bandung, West Java, Indonesia 40132
  • TENNY SETIANI DEWI Department of Oral Medicine, Faculty of Dentistry, Universitas Padjadjaran, Jl. Sekeloa Selatan No. 1, Bandung, West Java, Indonesia 40132
  • WAHYU HIDAYAT Department of Oral Medicine, Faculty of Dentistry, Universitas Padjadjaran, Jl. Sekeloa Selatan No. 1, Bandung, West Java, Indonesia 40132



Mouthwash, Mouth rinse, Oral lichen planus


This study aid to describe the advantages of herbal mouthwash therapy in Oral Lichen Planus (OLP). This systematic review was carried out using PRISMA methods. The selected articles were published in the last five years from PubMed and Google Scholar with the keywords mouthwash, mouth rinse, and Oral Lichen Planus was conducted in June 2022. The assessment of the risk of bias uses the Oxford Scoring System. A total of 2225 journals were found, and seven articles were obtained through screening. After the risk of bias assessment, six articles of high-range quality and one article of low-range quality were obtained. The six journals are randomized clinical trials of herbal mouthwashes and synthetic mouthwashes. Three articles on herbal mouthwash, two articles on synthetic mouthwash, and one article comparing herbal and synthetic mouthwashes. These articles show differences in the time, size, and pain of using herbal and synthetic mouthwashes; they also found side effects when using synthetic mouthwashes compared to herbal mouthwashes. Herbal mouthwash has fewer side effects than synthetic mouthwash, although clinically, synthetic mouthwash is more effective than herbal mouthwash.


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Lodi G, Manfredi M, Mercadante V, Murphy R, Carrozzo M. Interventions for treating oral lichen planus: corticosteroid therapies. Cochrane Database Syst Rev. 2020;2:CD001168. doi: 10.1002/14651858.CD001168.pub3. PMID 32108333.

Ghahremanlo A, Boroumand N, Ghazvini K, Hashemy SI. Herbal medicine in oral lichen planus. Phytother Res. 2019;33(2):288-93. doi: 10.1002/ptr.6236. PMID 30421555.

Mortazavi H, Safi Y, Baharvand M, Jafari S, Anbari F, Rahmani S. Oral white lesions: an updated clinical diagnostic decision tree. Dent J (Basel). 2019;7(1):1-24. doi: 10.3390/dj7010015, PMID 30736423.

Lima MR, Hoffmann SMS, Studzinki MS, Passoni GNS. Oral lichen planus: from diagnosis to treatment. Craniofac Res Connect J. 2022;1:33-40. doi: 10.7551/mitpress/4946.003.0018.

Glick M. Burket’s oral medicine. 12th ed. Shelton, (CT): People’s Medical Publishing House; 2015.

Rotaru D, Chisnoiu R, Picos AM, Picos A, Chisnoiu A. Treatment trends in oral lichen planus and oral lichenoid lesions (Review). Exp Ther Med. 2020;20(6):198. doi: 10.3892/etm.2020.9328. PMID 33123228.

Chandran S, Thomas P, Shajahan F. Oral potential lesions: a clinical perspective for diagnosis and treatment. J Indian Dent Assoc Thiruvalla. 2020;1:69-83.

Carrozzo M, Porter S, Mercadante V, Fedele S. Oral lichen planus: a disease or a spectrum of tissue reactions? Types, causes, diagnostic algorhythms, prognosis, and management strategies. Periodontol 2000. 2019;80(1):105-25. doi: 10.1111/prd.12260, PMID 31090143.

Hargitai IA. Painful Oral Lesions. Dent Clin North Am. 2018;62(4):597-609. doi: 10.1016/j.cden.2018.06.002. PMID 30189985.

Goncalves S, Dionne RA, Moses G, Carrozzo M. Pharmacotherapeutic approaches in oral medicine; 2019. doi: 10.1007/978-3-319-72303-7.

Bruckmann C, Seemann R, Rappersberger K, Rausch Fan X, Haririan H, Dvorak G. Is topical application of hyaluronic acid in oral lichen planus effective? A randomized controlled crossover study. Appl Sci. 2020;10(22):1-14. doi: 10.3390/app10227988.

Salehi B, Lopez Jornet P, Pons Fuster Lopez E, Calina D, Sharifi Rad M, Ramirez Alarcon K. Plant-derived bioactives in oral mucosal lesions: a key emphasis to curcumin, lycopene, chamomile, Aloe vera, green tea and coffee properties. Biomolecules. 2019;9(3). doi: 10.3390/biom9030106. PMID 30884918.

Kulaksiz B, Er S, Ustundag Okur N, Saltan Işcan G. Investigation of antimicrobial activities of some herbs containing essential oils and their mouthwash formulations. Turk J Pharm Sci. 2018;15(3):370-5. doi: 10.4274/tjps.37132, PMID 32454684.

Shivani R, Vasanth S, Sharmila M, Vivekanandan U. An overview of exclusive pharmacotherapeutic agents and aids used in the dental field. Int J Drug Res Dental Sci. 2020. doi: 10.36437/ijdrd.2020.2.1.K.

Rudralingam M, Randall C, Mighell AJ. The use of topical steroid preparations in oral medicine in the UK. Br Dent J. 2017;223(9):633-8. doi: 10.1038/sj.bdj.2017.880. PMID 29097797.

Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLOS Med. 2009;6(7):e1000100. doi: 10.1371/journal.pmed.1000100. PMID 19621070.

Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJM, Gavaghan DJ. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials. 1996;17(1):1-12. doi: 10.1016/0197-2456(95)00134-4, PMID 8721797.

Wahyuni IS, Sufiawati I, Nittayananta W, Puspitasari IM, Levita J. Efficacy and safety of plant-based therapy on recurrent aphthous stomatitis and oral mucositis in the past decade: a systematic review. J Herb Med Pharmacol. 2021;10(2):179-87. doi: 10.34172/jhp.2021.19.

Mansourian A, Agha Hosseini F, Kazemi HH, Mortazavi N, Moosavi MS, Beytollahi J. Salivary oxidative stress in oral lichen planus treated with triamcinolone mouth rinse. Dent Res J (Isfahan). 2017;14(2):104-10. doi: 10.4103/1735-3327.205794, PMID 28584533.

Zaslansky R, Schramm C, Stein C, Guthoff C, Schmidt Westhausen AM. Topical application of morphine for wound healing and analgesia in patients with oral lichen planus: a randomized, double-blind, placebo-controlled study. Clin Oral Investig. 2018;22(1):305-11. doi: 10.1007/s00784-017-2112-4. PMID 28353022.

Bakhshi M, Gholami S, Mahboubi A, Jaafari MR, Namdari M. Combination therapy with 1% nano curcumin gel and 0.1% triamcinolone acetonide mouth rinse for oral lichen planus: a randomized, double-blind placebo-controlled clinical trial. Dermatol Res Pract. 2020;2020:1-7. doi: 10.1155/ 2020/4298193.

Santonocito S, Polizzi A, De Pasquale R, Ronsivalle V, Lo Giudice A, Isola G. Analysis of the efficacy of two treatment protocols for patients with symptomatic oral lichen planus: a randomized clinical trial. Int J Environ Res Public Health. 2020;18(1). doi: 10.3390/ijerph18010056. PMID 33374791.

Polizzi A, Santonocito S, Lo Giudice A, Alibrandi A, De Pasquale R, Isola G. Analysis of the response to two pharmacological protocols in patients with oral lichen planus: A randomized clinical trial. Oral Dis. 2021:1-9. doi: 10.1111/odi.13960, PMID 34252252.

Kakoei S, Karbasi N, Raeiszadeh M, Tajadini H, Nekouei AH. The efficacy of henna (Lawsonia inermis L.) mouthwash versus chlorhexidine gluconate 0.2% mouthwash as adjuvant therapy of oral lichen planus: A randomized, double-blind clinical trial. J Ethnopharmacol. 2022:1-7. doi: 10.1016/j.

Georgaki M, Piperi E, Theofilou VI, Pettas E, Stoufi E, Nikitakis NG. A randomized clinical trial of topical dexamethasone vs. cyclosporine treatment for oral lichen planus. Med Oral Patol Oral Cir Bucal. 2022;27(2):e113-24. doi: 10.4317/medoral.25040, PMID 34564686.

Kalaskar AR, Bhowate RR, Kalaskar RR, Ghonmode S. Novel neem leaves extract mouthwash therapy for oral lichen planus. J Herb Med. 2021;26. doi: 10.1016/j.hermed.2020.100408.

Kaur R, Tirth A, Ravishankar TL, Kaur S, Bhattacharyya S, Hamid N. Dental herbalism: a review. J Med Plants Stud. 2017;5:196-9.

Dhaliwal JS, Gambhir RS, Sodhi SK, Shaheed G, Kifli NBPHM. Herbs and their use in oral care: a review. Brunei Darussalam J Heal. 2017;1:5-17.

Nosek K, Leppert W, Puchała L, Lon K. Efficacy and safety of topical morphine: A narrative review. Pharmaceutics. 2022;14(7):1-11. doi: 10.3390/pharmaceutics14071499, PMID 35890392.

Rosenblum A, Marsch LA, Joseph H, Portenoy RK. Opioids and the treatment of chronic pain: controversies, current status, and future directions. Exp Clin Psychopharmacol. 2008;16(5):405-16. doi: 10.1037/a0013628. PMID 18837637.

Rai A, Kumar A, Hasan S, Saeed S. Curcumin in oral mucosal lesions: an update. Asian J Pharm Clin Res. 2019;12:32-43. doi: 10.22159/ajpcr.2019.v12i2.22458.

Biswas S, Ranjan V, Arora P, Rastogi T. Efficacy of topical curcumin compared to topical triamcinolone in the treatment of oral lichen planus-a randomized clinical trial. Int J Curr Pharm Res. 2018;1-6:20180428. doi: 10.24327/23956429.

Kunnumakkara AB, Bordoloi D, Padmavathi G, Monisha J, Roy NK, Prasad S. Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases. Br J Pharmacol. 2017;174(11):1325-48. doi: 10.1111/bph.13621. PMID 27638428.

Hakeem KR, Abdul WM, Hussain MM, Razvi SSI. Role of medicinal plant species in oral health sector. Springer Briefs in Public Health. 2019:19-28. doi: 10.1007/978-3-030-04336-0_5.

Baranwal R, Singh BD, Dubey A, Avinash A. Review article calcium hydroxide in Dentistry. Chettinad Heal City J. 2016;1:30-3.

Casale M, Moffa A, Vella P, Sabatino L, Capuano F, Salvinelli B. Hyaluronic acid: perspectives in dentistry. A systematic review. Int J Immunopathol Pharmacol. 2016;29(4):572-82. doi: 10.1177/0394632016652906, PMID 27280412.

Mazimba O. Umbelliferone: Sources, chemistry and bioactivities review. Bull Fac Pharm Cairo Univ. 2017;55(2):223-32. doi: 10.1016/j.bfopcu.2017.05.001.

Farjana HN, Ambika S, Mary A. An oligomeric pro-anthocyanidin nutritional supplement in the treatment of gingivitis–a pilot study. Res J Pharmacol. 2019;8:6-10.

Rauf A, Imran M, Abu-Izneid T, Iahtisham-Ul-Haq, Patel S, Pan X. Proanthocyanidins: A comprehensive review. Biomed Pharmacother. 2019;116:108999. doi: 10.1016/j.biopha. 2019.108999. PMID 31146109.

Vepachedu S. Henna. Educ Found. 2015:1-8.

James P, Worthington HV, Parnell C, Harding M, Lamont T, Cheung A. Chlorhexidine mouth rinse as an adjunctive treatment for gingival health. Cochrane Database Syst Rev. 2017;3:CD008676. doi: 10.1002/14651858.CD008676.pub2. PMID 28362061.

Salman BN, Vahabi S, Rad MM. Use of herbs and medicinal plants in dentistry: a review. J Dent Sch. 2017;2:58-64.

Iglesias Sancho M, Llambi Mateos F, Salleras Redonnet M. Drug compounding for diseases of the oral mucosa. Actas Dermosifiliogr (Engl Ed). 2020;111(10):822-8. doi: 10.1016/ PMID 32910921.

Jayasheela M, Mehta DS. The role of cyclosporine a on the periodontal tissues. Dent Res J (Isfahan). 2013;10(6):802-8. doi: 10.4103/1735-3327.122491, PMID 24379871.

Park SY, Lee HJ, Kim SH, Kim SB, Choi YH, Kim YK. Factors affecting treatment outcomes in patients with oral lichen planus lesions: a retrospective study of 113 cases. J Periodontal Implant Sci. 2018;48(4):213-23. doi: 10.5051/ jpis.2018.48.4.213. PMID 30202605.

Pradhan R, Dandawate P, Vyas A, Padhye S, Biersack B, Schobert R. From body art to anticancer activities: perspectives on medicinal properties of henna. Curr Drug Targets. 2012;13(14):1777-98. doi: 10.2174/138945012804545588, PMID 23140289.



How to Cite

SANTO, A. N. T., DEWI, T. S., & HIDAYAT, W. (2022). THE USE OF HERBAL MOUTHWASH THERAPY IN ORAL LICHEN PLANUS: A SYSTEMATIC REVIEW. International Journal of Applied Pharmaceutics, 14(4), 12–18.



Review Article(s)