• BHUPINDER KAUR Department of Pharmaceutics, University Institute of Pharma Sciences, Chandigarh University, Gharuan, Mohali, Punjab, India https://orcid.org/0000-0002-8423-6613
  • NISHANT THAKUR Department of Pharmaceutics, University Institute of Pharma Sciences, Chandigarh University, Gharuan, Mohali, Punjab, India
  • MANISH GOSWAMI Saraswati group of Colleges, Gharuan, Mohali, Punjab, India https://orcid.org/0000-0002-8741-7030




TDDS, Microneedles, Patents, Skin, Commercial market


The market size for transdermal drug delivery systems was assessed at USD 5.9 billion in 2020 and is expected to reach USD 8.4 billion by 2028, expanding at a compound annual growth rate (CAGR) of 4.5% from 2021 to 2028. Micro Jet injectors, iontophoresis, electroporation, sonophoresis, microneedles, powdered injection, surface ablation, jet injectors and stripping by tape are some of the methods that enhance the delivery and ease of administration of larger molecules which is the major hindrance in case of Transdermal drug delivery system (TDDS). This type of delivery offers immediate delivery and avoids lag time. Microneedles are hollow cannulas inserted into the skin at 50 µm to 500 µm. The microneedle drug delivery systems market is projected to register a CAGR of 7.8% during the forecast period of 2022-2027. The microneedle drug delivery systems market is segmented by product type (solid, hollow, coated, and dissolvable), application (drug delivery, vaccine delivery, dermatology, and other applications), and geography (North America, Europe, Asia-Pacific, Middle-East and Africa, and South America). This review summerizes the recent patents granted in the area of micro-needling in the year 2022 and also the commercial market of microneedles until now.


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Brown MB, Martin GP, Jones SA, Akomeah FK. Dermal and transdermal Drug Delivery Systems: current and future prospects. Drug Deliv. 2006;13(3):175-87. doi: 10.1080/10717540500455975, PMID 16556569.

Murthy SN, Shivakumar HN, CHAPTER. 1-topical and transdermal drug delivery. In: Kulkarni VS, editor. Personal care and cosmetic technology, handbook of non-invasive drug delivery systems. William Andrew Publishing; ISBN 9780815520252; 2010. p. 1-36.

Benson HA. Transdermal drug delivery: penetration enhancement techniques. Curr Drug Deliv. 2005;2(1):23-33. doi: 10.2174/1567201052772915, PMID 16305405.

Nagdev SA, Agrawal O, Rageeb Md, Usman Md. Transdermal drug delivery system: an overview. Res J Pharm Technol. 2022;15(3):1371-7. doi: 10.52711/0974-360X.2022.00229.

Stanekzai A, Sudhakar CK, Zhakfar AM, Karan VS. Recent approaches in transdermal drug delivery system. Res J Pharm Technol. 2019;12(9):4550-8. doi: 10.5958/0974-360X.2019.00783.2.

Rastogi V, Yadav P. Transdermal drug delivery system: an overview. Asian J Pharm. 2012;6(3). doi: 10.4103/0973-8398.104828.

Alkilani AZ, McCrudden MT, Donnelly RF. Transdermal drug delivery: innovative pharmaceutical developments based on disruption of the barrier properties of the stratum corneum. Pharmaceutics. 2015;7(4):438-70. doi: 10.3390/pharmaceutics7040438, PMID 26506371.

Marwah H, Garg T, Goyal AK, Rath G. Permeation enhancer strategies in transdermal drug delivery. Drug Deliv. 2016;23(2):564-78. doi: 10.3109/10717544.2014.935532, PMID 25006687.

Kogan A, Garti N. Microemulsions as transdermal drug delivery vehicles. Adv Colloid Interface Sci. 2006;123-126:369-85. doi: 10.1016/j.cis.2006.05.014, PMID 16843424.

Jeong WY, Kwon M, Choi HE, Kim KS. Recent advances in transdermal drug delivery systems: a review. Biomater Res. 2021;25(1):24. doi: 10.1186/s40824-021-00226-6, PMID 34321111.

Alkilani AZ, McCrudden MT, Donnelly RF. Transdermal drug delivery: innovative pharmaceutical developments based on disruption of the barrier properties of the stratum corneum. Pharmaceutics. 2015;7(4):438-70. doi: 10.3390/pharmaceutics7040438, PMID 26506371.

Anod HV, Gupta NV, Gowda DV, MM. Preparation and evaluation of simvastatin transdermal film. Int J App Pharm. 2018;10(5). doi: 10.22159/ijap.2018v10i5.26657.

Scheindlin S. Transdermal drug delivery: past, Present, Future. Mol Interv. 2004;4(6):308-12. doi: 10.1124/mi.4.6.1, PMID 15616157.

Kalia YN, Guy RH. Modeling transdermal drug release. Adv Drug Deliv Rev. 2001;48(2-3):159-72. doi: 10.1016/s0169-409x(01)00113-2, PMID 11369080.

ChanderJhawat V, Saini V, Kamboj S, Maggon N. Transdermal drug delivery systems: approaches and advancements in drug absorption through skin. Int J Pharm Sci Rev Res. 2013;10:47-56.

Ranade VV. Drug delivery systems. 6. Transdermal drug delivery. J Clin Pharmacol. 1991;31(5):401-18. doi: 10.1002/j.1552-4604.1991.tb01895.x, PMID 2050824.

Subedi RK, Oh SY, Chun MK, Choi HK. Recent advances in transdermal drug delivery. Arch Pharm Res. 2010;33(3):339-51. doi: 10.1007/s12272-010-0301-7, PMID 20361297.

Rizwan M, Aqil M, Talegaonkar S, Azeem A, Sultana Y, Ali A. Enhanced transdermal drug delivery techniques: an extensive review of patents. Recent Pat Drug Deliv Formul. 2009;3(2):105-24. doi: 10.2174/187221109788452285, PMID 19519571.

Fukushima K, Ise A, Morita H, Hasegawa R, Ito Y, Sugioka N. Two-layered dissolving microneedles for percutaneous delivery of peptide/protein drugs in rats. Pharm Res. 2011;28(1):7-21. doi: 10.1007/s11095-010-0097-7, PMID 20300802.

Ito Y, Hirono M, Fukushima K, Sugioka N, Takada K. Two-layered dissolving microneedles formulated with intermediate-acting insulin. Int J Pharm. 2012;436(1-2):387-93. doi: 10.1016/j.ijpharm.2012.06.047, PMID 22750407.

Rao R, Mahant S, Chhabra L, Nanda S. Transdermal innovations in diabetes management. Curr Diabetes Rev. 2014;10(6):343-59. doi: 10.2174/1573399810666141124110836, PMID 25418713.

Kim YC, Park JH, Prausnitz MR. Microneedles for drug and vaccine delivery. Adv Drug Deliv Rev. 2012;64(14):1547-68. doi: 10.1016/j.addr.2012.04.005, PMID 22575858.

Prausnitz MR. Microneedles for transdermal drug delivery. Adv Drug Deliv Rev. 2004;56(5):581-7. doi: 10.1016/j.addr.2003.10.023, PMID 15019747.

Ita K. Transdermal delivery of drugs with microneedles-potential and challenges. Pharmaceutics. 2015;7(3):90-105. doi: 10.3390/pharmaceutics7030090, PMID 26131647.

Park JH, Allen MG, Prausnitz MR. Biodegradable polymer microneedles: fabrication, mechanics and transdermal drug delivery. J Control Release. 2005;104(1):51-66. doi: 10.1016/j.jconrel.2005.02.002, PMID 15866334.

Bariya SH, Gohel MC, Mehta TA, Sharma OP. Microneedles: an emerging transdermal drug delivery system. J Pharm Pharmacol. 2012;64(1):11-29. doi: 10.1111/j.2042-7158.2011.01369.x, PMID 22150668.

Van der Maaden K, Jiskoot W, Bouwstra J. Microneedle technologies for (trans)dermal drug and vaccine delivery. J Control Release. 2012;161(2):645-55. doi: 10.1016/j.jconrel.2012.01.042, PMID 22342643.

Henry S, McAllister DV, Allen MG, Prausnitz MR. Microfabricated microneedles: A novel approach to transdermal drug delivery. J Pharm Sci. 1999;88(9):948. doi: 10.1021/js990783q, PMID 10479360.

McAllister DV, Allen MG, Prausnitz MR. Microfabricated microneedles for gene and drug delivery. Annu Rev Biomed Eng. 2000;2:289-313. doi: 10.1146/annurev.bioeng.2.1.289, PMID 11701514.

Gill HS, Prausnitz MR. Coated microneedles for transdermal delivery. J Control Release. 2007 Feb 12;117(2):227-37. doi: 10.1016/j.jconrel.2006.10.017, PMID 17169459.

Ling MH, Chen MC. Dissolving polymer microneedle patches for rapid and efficient transdermal delivery of insulin to diabetic rats. Acta Biomater. 2013;9(11):8952-61. doi: 10.1016/j.actbio.2013.06.029, PMID 23816646.

Henry S, McAllister DV, Allen MG, Prausnitz MR. Microfabricated microneedles: a novel approach to transdermal drug delivery. J Pharm Sci. 1998;87(8):922-5. doi: 10.1021/js980042+, PMID 9687334.

Wang M, Hu L, Xu C. Recent advances in the design of polymeric microneedles for transdermal drug delivery and biosensing. Lab Chip. 2017;17(8):1373-87. doi: 10.1039/c7lc00016b, PMID 28352876.

Indermun S, Luttge R, Choonara YE, Kumar P, Du Toit LC, Modi G. Current advances in the fabrication of microneedles for transdermal delivery. J Control Release. 2014;185(1):130-8. doi: 10.1016/j.jconrel.2014.04.052, PMID 24806483.

Bhatnagar S, Dave K, Venuganti VVK. Microneedles in the clinic. J Control Release. 2017 Aug 28;260:164-82. doi: 10.1016/j.jconrel.2017.05.029, PMID 28549948.

Waghule T, Singhvi G, Dubey SK, Pandey MM, Gupta G, Singh M. Microneedles: A smart approach and increasing potential for transdermal drug delivery system. Biomed Pharmacother. 2019;109:1249-58. doi: 10.1016/j.biopha.2018.10.078, PMID 30551375.

Tsioris K, Raja WK, Pritchard EM, Panilaitis B, Kaplan DL, Omenetto FG. Fabrication of silk microneedles for controlled-release drug delivery. Adv Funct Mater. 2012;22(2):330-5. doi: 10.1002/adfm.201102012.

Cheung K, Das DB. Microneedles for drug delivery: trends and progress. Drug Deliv. 2016 Sep;23(7):2338-54. doi: 10.3109/10717544.2014.986309, PMID 25533874.

Escobar Chavez JJ, Bonilla Martinez D, Villegas Gonzalez MA, Molina Trinidad E, Casas Alancaster N, Revilla Vazquez AL. Microneedles: A valuable physical enhancer to increase transdermal drug delivery. J Clin Pharmacol. 2011;51(7):964-77. doi: 10.1177/0091270010378859, PMID 21148047.

Ma G, Wu C. Microneedle, bio-microneedle and bio-inspired microneedle: a review. J Control Release. 2017;251:11-23. doi: 10.1016/j.jconrel.2017.02.011, PMID 28215667.

Kim YC, Park JH, Prausnitz MR. Microneedles for drug and vaccine delivery. Adv Drug Deliv Rev. 2012;64(14):1547-68. doi: 10.1016/j.addr.2012.04.005, PMID 22575858.

Serrano Castaneda P, Escobar Chavez JJ, Rodriguez Cruz IM, Melgoza LM, Martinez Hernandez J. Microneedles as enhancer of drug absorption through the skin and applications in medicine and cosmetology. J Pharm Pharm Sci. 2018;21(1):73-93. doi: 10.18433/jpps29610, PMID 29510800.

Larraneta E, Lutton REM, Woolfson AD, Donnelly RF. Microneedle arrays as transdermal and intradermal drug delivery systems: materials science, manufacture and commercial development. Materials Science and Engineering: R: Reports. 2016;104:1-32. doi: 10.1016/j.mser.2016.03.001.

Schoellhammer CM, Blankschtein D, Langer R. Skin permeabilization for transdermal drug delivery: recent advances and future prospects. Expert Opin Drug Deliv. 2014;11(3):393-407. doi: 10.1517/17425247.2014.875528, PMID 24392787.

Davidson A, Al-Qallaf B, Das DB. Transdermal drug delivery by coated microneedles: Ggeometry effects on effective skin thickness and drug permeability. Chem Eng Res Des. 2008;86(11):1196-206. doi: 10.1016/j.cherd.2008.06.002.

He X, Sun J, Zhuang J, Xu H, Liu Y, Wu D. Microneedle system for transdermal drug and vaccine delivery: devices, safety, and prospects. Dose Response Dose Response. 2019;17(4):1559325819878585. doi: 10.1177/1559325819878585, PMID 31662709.

Gill HS, Prausnitz MR. Coating formulations for microneedles. Pharm Res. 2007;24(7):1369-80. doi: 10.1007/s11095-007-9286-4, PMID 17385011.

Kim YC, Quan FS, Compans RW, Kang SM, Prausnitz MR. Formulation and coating of microneedles with inactivated influenza virus to improve vaccine stability and immunogenicity. J Control Release. 2010;142(2):187-95. doi: 10.1016/j.jconrel.2009.10.013, PMID 19840825.

Grace JM, Marijnissen JCM. A review of liquid atomization by electrical means. J Aerosol Sci. 1994;25(6):1005-19. doi: 10.1016/0021-8502(94)90198-8.

Angkawinitwong U, Courtenay AJ, Rodgers AM, Larraneta E, McCarthy HO, Brocchini S. A novel transdermal protein delivery strategy via electrohydrodynamic coating of PLGA microparticles onto microneedles. ACS Appl Mater Interfaces. 2020;12(11):12478-88. doi: 10.1021/acsami.9b22425, PMID 32066234.

Tarbox TN, Watts AB, Cui Z, Williams RO 3rd. An update on coating/manufacturing techniques of microneedles. Drug Deliv Transl Res. 2018 Dec;8(6):1828-43. doi: 10.1007/s13346-017-0466-4, PMID 29288358.

Boehm RD, Miller PR, Daniels J, Stafslien S, Narayan RJ. Inkjet printing for pharmaceutical applications. Mater Today. 2014;17(5):247-52. doi: 10.1016/j.mattod.2014.04.027.

Uddin MJ, Scoutaris N, Klepetsanis P, Chowdhry B, Prausnitz MR, Douroumis D. Inkjet printing of transdermal microneedles for the delivery of anticancer agents. Int J Pharm. 2015;494(2):593-602. doi: 10.1016/j.ijpharm.2015.01.038, PMID 25617676.

Boehm RD, Miller PR, Schell WA, Perfect JR, Narayan RJ. Inkjet printing of amphotericin B onto biodegradable microneedles using piezoelectric inkjet printing. JOM. 2013;65(4):525-33. doi: 10.1007/s11837-013-0574-7.

Haj Ahmad R, Khan H, Arshad MS, Rasekh M, Hussain A, Walsh S. Microneedle coating techniques for transdermal drug delivery. Pharmaceutics. 2015;7(4):486-502. doi: 10.3390/pharmaceutics7040486, PMID 26556364.

Hao Y, Li W, Zhou XL, Yang F, Qian ZY. Microneedles-based transdermal drug delivery systems: a review. J Biomed Nanotechnol. 2017;13(12):1581-97. doi: 10.1166/jbn.2017.2474, PMID 29490749.

Martanto W, Davis SP, Holiday NR, Wang J, Gill HS, Prausnitz MR. Transdermal delivery of insulin using microneedles in vivo. Pharm Res. 2004 Jun;21(6):947-52. doi: 10.1023/b:pham.0000029282.44140.2e, PMID 15212158.

Li WZ, Huo MR, Zhou JP, Zhou YQ, Hao BH, Liu T, Zhang Y. Super-short solid silicon microneedles for transdermal drug delivery applications. Int J Pharm. 2010 Apr 15;389(1-2):122-9. doi: 10.1016/j.ijpharm.2010.01.024, PMID 20096759.

Omolu A, Bailly M, Day RM. Assessment of solid microneedle rollers to enhance transmembrane delivery of doxycycline and inhibition of MMP activity. Drug Deliv. 2017;24(1):942-51. doi: 10.1080/10717544.2017.1337826, PMID 28618841.

Chen Y, Chen BZ, Wang QL, Jin X, Guo XD. Fabrication of coated polymer microneedles for transdermal drug delivery. J Control Release. 2017;265:14-21. doi: 10.1016/j.jconrel.2017.03.383, PMID 28344014.

Lee JW, Park JH, Prausnitz MR. Dissolving microneedles for transdermal drug delivery. Biomaterials. 2008;29(13):2113-24. doi: 10.1016/j.biomaterials.2007.12.048, PMID 18261792.

Ita K. Dissolving microneedles for transdermal drug delivery: advances and challenges. Biomed Pharmacother. 2017;93:1116-27. doi: 10.1016/j.biopha.2017.07.019, PMID 28738520.

Davis SP, Martanto W, Allen MG, Prausnitz MR. Hollow metal microneedles for insulin delivery to diabetic rats. IEEE Trans Biomed Eng. 2005;52(5):909-15. doi: 10.1109/TBME.2005.845240, PMID 15887540.

Ita K. Ceramic microneedles and hollow microneedles for transdermal drug delivery: two decades of research. Journal of Drug Delivery Science and Technology. 2018;44:314-22. doi: 10.1016/j.jddst.2018.01.004.

Ashraf MW, Tayyaba S, Nisar A, Afzulpurkar N, Bodhale DW, Lomas T, Poyai A, Tuantranont A. Design, fabrication and analysis of silicon hollow microneedles for transdermal drug delivery system for treatment of hemodynamic dysfunctions. Cardiovasc Eng. 2010;10(3):91-108. doi: 10.1007/s10558-010-9100-5, PMID 20730492.

Vinayakumar KB, Hegde GM, Nayak MM, Dinesh NS, Rajanna K. Fabrication and characterization of gold coated hollow silicon microneedle array for drug delivery. Microelectron Eng. 2014;128(5):12-8. doi: 10.1016/j.mee.2014.05.039.

WM, JSM OK, RK, PMW, JM O. Microinfusion using hollow microneedles. Pharm Res. 2006 Jan;23(1):104-13.

Shawgo RS, Richards Grayson ACR, Li Y, Cima MJ. BioMEMS for drug delivery. Curr Opin Solid State Mater Sci. 2002;6(4):329-34. doi: 10.1016/S1359-0286(02)00032-3.

Forvi E, Bedoni M, Carabalona R, Soncini M, Mazzoleni P, Rizzo F. Preliminary technological assessment of microneedles-based dry electrodes for biopotential monitoring in clinical examinations. Sensors and Actuators A: Physical. 2012;180:177-86. doi: 10.1016/j.sna.2012.04.019.

Davis SP, Prausnitz MR, Allen MG. Fabrication and characterization of laser micromachined hollow microneedles. In: Transducers. Vol. 2; 2003. p. 1435-8. doi: 10.1109/SENSOR.2003.1217045.

Hong X, Wei L, Wu F, Wu Z, Chen L, Liu Z, Yuan W. Dissolving and biodegradable microneedle technologies for transdermal sustained delivery of drug and vaccine. Drug Des Devel Ther. 2013;7:945-52. doi: 10.2147/DDDT.S44401, PMID 24039404.

Ye Y, Yu J, Wen D, Kahkoska AR, Gu Z. Polymeric microneedles for transdermal protein delivery. Advanced Drug Delivery Reviews. 2018 Mar;127:106-18. doi: 10.1016/j.addr.2018.01.015, PMID 29408182.

Teo MA, Shearwood C, Ng KC, Lu J, Moochhala S. In vitro and in vivo characterization of MEMS microneedles. Biomed Microdevices. 2005;7(1):47-52. doi: 10.1007/s10544-005-6171-y, PMID 15834520.

El-Laboudi A, Oliver NS, Cass A, Johnston D. Use of microneedle array devices for continuous glucose monitoring: a review. Diabetes Technol Ther. 2013;15(1):101-15. doi: 10.1089/dia.2012.0188, PMID 23234256.

Kolli CS, Banga AK. Characterization of solid maltose microneedles and their use for transdermal delivery. Pharm Res. 2008;25(1):104-13. doi: 10.1007/s11095-007-9350-0, PMID 17597381.

Wu X, Chen Y, Gui S, Wu X, Chen L, Cao Y, Yin D, Ma P. Sinomenine hydrochloride-loaded dissolving microneedles enhanced its absorption in rabbits. Pharm Dev Technol. 2016;21(7):787-93. doi: 10.3109/10837450.2015.1055766, PMID 26122959.

Chen B, Wei J, Iliescu C. Sonophoretic enhanced microneedles array (SEMA)-improving the efficiency of transdermal drug delivery. Sensors Actuators, B Chem. 2010;145(1):54-60. doi: 10.1016/j.snb.2009.11.013.

Bal SM, Caussin J, Pavel S, Bouwstra JA. In vivo assessment of safety of microneedle arrays in human skin. Eur J Pharm Sci. 2008;35(3):193-202. doi: 10.1016/j.ejps.2008.06.016, PMID 18657610.

Ventrelli L, Marsilio Strambini L, Barillaro G. Microneedles for transdermal biosensing: current picture and future direction. Adv Healthc Mater. 2015;4(17):2606-40. doi: 10.1002/adhm.201500450, PMID 26439100.

Qiu Y, Gao Y, Hu K, Li F. Enhancement of skin permeation of docetaxel: a novel approach combining microneedle and elastic liposomes. J Control Release. 2008;129(2):144-50. doi: 10.1016/j.jconrel.2008.04.019, PMID 18538885.

Wing D, Prausnitz MR, Buono MJ. Skin pretreatment with microneedles prior to pilocarpine iontophoresis increases sweat production. Clin Physiol Funct Imaging. 2013;33(6):436-40. doi: 10.1111/cpf.12053, PMID 23701521.

Ameri M, Kadkhodayan M, Nguyen J, Bravo JA, Su R, Chan K, Samiee A, Daddona PE. Human growth hormone delivery with a microneedle transdermal system: preclinical formulation, stability, delivery and PK of therapeutically relevant doses. Pharmaceutics. 2014;6(2):220-34. doi: 10.3390/pharmaceutics6020220, PMID 24838219.

Ito Y, Yoshimitsu J, Shiroyama K, Sugioka N, Takada K. Self-dissolving microneedles for the percutaneous absorption of EPO in mice. J Drug Target. 2006;14(5):255-61. doi: 10.1080/10611860600785080, PMID 16882545.

Singh I, Morris AP. Performance of transdermal therapeutic systems: effects of biological factors. Int J Pharm Investig. 2011;1(1):4-9. doi: 10.4103/2230-973X.76721, PMID 23071913.

Tuan Mahmood TM, McCrudden MT, Torrisi BM, McAlister E, Garland MJ, Singh TR, Donnelly RF. Microneedles for intradermal and transdermal drug delivery. Eur J Pharm Sci. 2013;50(5):623-37. doi: 10.1016/j.ejps.2013.05.005, PMID 23680534.

Prausnitz MR, Langer R. Transdermal drug delivery. Nat Biotechnol. 2008;26(11):1261-8. doi: 10.1038/nbt.1504, PMID 18997767.

Leroux Roels I, Weber F. IntanzaWeber F (®) 9 µg intradermal seasonal influenza vaccine for adults 18 to 59 y of age. Intanza (®) 9 µg intradermal seasonal influenza vaccine for adults 18 to 59 years of age. Hum Vaccin Immunother. 2013;9(1):115-21. doi: 10.4161/hv.22342, PMID 23442585.

Cosaco. Corium Inc.-delivering innovative transdermal solutions; 2022. Available from: https://corium/about-us.html#:~:text=Solutions%20That%20Transform%20Careandtext=Corium%20is%20a%20commercial%2Dstage,their%20families%2C%20and%20their%20caregivers. [Last accessed on 12 Oct 2022]

Levin Y, Kochba E, Kenney R. Clinical evaluation of a novel microneedle device for intradermal delivery of an influenza vaccine: are all delivery methods the same? Vaccine. 2014;32(34):4249-52. doi: 10.1016/j.vaccine.2014.03.024, PMID 24930715.

Fierce Biotech. CE mark approval for the V-GoTM disposable insulin delivery device; valeritas receives European CE mark approval for the V-GoTM disposable insulin delivery device | Fierce biotech; 2011. Available from: https://www.fiercebiotech.biotechPublishing/valeritas-receives-european-ce-mark-approval-for-v-gotm-disposable-insulin-delivery-device.com [Last accessed on 12 Oct 2022]

Vaxxas. Vaxxas: technology platform; 2021. Available from: https://www.vaxxas.com/technology-platform [Last accessed on 12 Oct 2022]

Zosano Pharma. Globe newswire, zosano pharma announces positive phase 2 results for its zp-glucagon patch program for treatment of severe. Hypoglycemia; 2012.

Derma spark: Dermaroller Micro Needling-DermaSpark Products Inc; 2022. Available from: DermarollerMicroNeedling-DermaSparkProductsInc.

Kansai Bio Venture view; 2001. Available from: kinkibio-venture.kansaibio-ventureviewCosMEDpharmaceuticalColo.Ltd.Com [Last accessed on 12 Oct 2022]

Kommareddy S, Baudner BC, Oh S, Kwon SY, Singh M, O'’Hagan DT. Dissolvable microneedle patches for the delivery of cell-culture-derived influenza vaccine antigens. J Pharm Sci. 2012;101(3):1021-7. doi: 10.1002/jps.23019, PMID 22190403.

Therajet. Welcome to TheraJect, Inc; 2022.

Nanotech; 2011. NanoTech: Exhibition. Available from: nanotech-montreux.com. [Last accessed on 12 Oct 2022]

Soluvia BD. BD Soluvia™ pre-fillable microinjection system-BD; 2011. [Last accessed on 12 Oct 2022]

Zosano Pharma. Launch of macroflux corporation | Zosano pharma corporation; 2011. [Last accessed on 12 Oct 2022]

Dermapen. Dermapen® | The World’s most advanced microneedling device; 2022. [Last accessed on 12 Oct 2022]

Dick LA. Innovatıve drug delivery technology to meet evolving need of biologıcs and small molecules. Available from: 3M_HR.pdf (ondrugdelivery.com). [Last accessed on 12 Oct 2022]

Marking CE. Seventh sense biosystems. Vol. II. 2021. Seventh Sense Biosystems Expands to European Markets for Consumer Blood Collection with TAP. Available from: yourbiohealth.com. [Last accessed on 12 Oct 2022]

Yu Yunlong Y, Zeng Rui Z, Qu Yan Q, Yang Xiao Y, Southwest National University. Microneedle for promoting wound healing. China Patent CN114668778A; 2022 Apr 19.

Ren C Kuen. Amer, Maher: University Washington State [US]. Microneedle array with an interlocking feature. European Patent WO2022197452A2; 2022 Sep 22.

Waldman Reid; Veradermics. Perilesional treatment of skin conditions. European Patent WO2022204255A1; 2022 Sep 29.

Young AJ, Hee JE, Albiti Inc. Microneedle biosensor and manufacturing method for same. European Patent WO2022149754A1; 2022 Aug 14.

Seemit P, Chu Heng L, Herrmann Douglas K, Lefevre Jason M, Mcconville Paul J, Xerox Corp. System and method for manufacturing microneedle assemblies with medicaments. US Patent US2022305736. Vol. A1; 2022 Sep 29.

Natalie A, Pere D, Nuria P, Zhabiz S, Karim Y, Jamil A. Massachusetts inst technology [US]. Microneedles and methods for treating the skin, European patent WO2022183126A; 2022 Sep 29.

Dean Kamen, Richard L, Deka Products Lp. Medical agent dispensing systems, methods, and apparatuses. US Patent US2022273924A; 2022 Sep 1.

Mccaffrey Maureen, Cardinali Steven, O'Connor Jason. Insulet corporation. Drug delivery device including pump with floating microneedle assembly. US Patent US2022273927. Vol. A1; 2022 Sep 1.

Hopcroft Matthew H. Laxmi therapeutic devices inc [US]. Needle sensor and method of manufacturing the same. US Patent US2022273240. Vol. A1; 2022 Sep 1.

Rhee Yun Seok RY, Song Sangbyeong S, Lee Jaemin L, Song Chanwoo S, Noh Inhwan N, Nat University, Gyeongsang Ia cf. Microneedle patch system for transdermal drug delivery. European patent WO2022177205A1; 2022 Aug 25.

Bai X, Nanomed Skincare Inc. Method of administering a dual therapeutic and cosmetic agent. US Patent US2022265589. Vol. A1; 2022 Aug 25.

Chang Sobin C, Nevrivy Daniel N, Sankaranarayan Saiprasad S, Aquavit pharmaceuticals Inc. Systems and methods for administering vaccine composition using modular multi-vial microchannel delivery adapter devices. European Patent WO2022173863A1; 2022 Aug 18.

Hiroko S, Takakazu Obana, Mika Y, Noriyuki O, Toda. Yasuhiro; shiseido Colo. Ltd [JP]. Needle applicator and puncture injection kit. Korea Patent KR102425556B1; 2022 Aug 11.

Ok KS, Sook YY, Heon KJ, Daewoong Therapeutics [KR]. Microneedle assembly. Korea Patent KR102425556B; 2022 Jul 11.

Kwak Min Kyu KM, Lee Yun Kyung LY, Eulji University Industry Academy. Coopera. Composition for treating atopy comprising nanosized bee pollen extract as an active ingredient and a microneedle patch using the same. Korea Patent KR20220104429A.; 2022 July 26.

Matsumoto Akira, Miyazaki TakuyaMT. Kanagawa institute of industrial science and tech [JP], university nat corp Tokyo medical and dental [JP]. Polyglycerol, complex gel composition containing said polyglycerol, drug delivery microneedle including said complex gel composition, and methods for producing same. European Patent WO2022154055A1; 2022 July 21.

Yan Qinying Y, Fang Min F, Yang Gensheng Y, Weng Jiaqi W, Shen Shulin S, Wang Yan W, Zhejiang Industrial University. Microneedle for treating psoriasis through percutaneous delivery of lipidosome and preparation method of microneedle. China Patent CN114432230A; 2022 May 6.

Gao Yunhua G, He Meilin H, Yang Guozhong Y, Zhang Suohui, Shenzhen College. Slow-release microneedle patch and preparation method there of. China Patent CN114668712A; 2022 March 24.

Gou Maling G, Li Rong L, University Sichuan. Preparation method of hollow microneedle patch, hollow microneedle patch and injection device. China Patent CN114344699A; 2022 Jan 11.

Che Huilian C, Zhang Erkang Z, Zeng Binghui Z, Liu Guirong L, Yao Lu Y, Wang Qi W. University chinese agricultural. Degradable slow-release composite microneedle for treating food allergy and preparation method thereof. China Patent CN114668709A; 2022 June 28.

Dong Liang D, Chen Yongli C, Zhang Shan Z, Zhang Yanyan Z, Gan Miao G. Shanghai Hu Yang Biotechnology Co Ltd. Soluble superoxide dismutase microneedle patch with anti-aging effect. China Patent CN114259458A; 2022 Jan 4.

Su Jianyu S, Fan Penghui F, Lyu Manxia L, Hou Yuchao H, Wang Yanjiao W. Xinxiang Shenzhen science and tech Colo. Ltd. Plum slice and borneol soluble micro-needle eye patch for removing eye puffiness and preparation method thereof. China Patent CN114366700A; 2022 April 19.

Leng Gang L, Lee Sung Guk LS, Ma Yonghao M, Youmicro Pearl Ha YP, Biotechnology Co Ltd. Soluble microneedle and manufacturing method there of. China Patent CN114558242; 2022 May 31.

Yanbiao C, Jiali C, Cong T, Li Sidong, Guangzhou Nali Biotechnology Co Ltd. Polydopamine photothermal conversion effect microneedle and preparation method thereof. China Patent CN114504727A (B); 2022 May 17.

Zheng Chao Z, Yu Xiang, Tanie, Zhang Yikai Z, Wang Shengyao W, Ye Shu Y, Hu Yepeng, Uuniversity Zhejiang. Glucagon loaded wearable device for treating hypoglycemia. China Patent CN114376569A; 2022 Jan 19.

Su Xiaodong S, Cheng Wei C, Zou Shuai Z, Ni Mengfei N, Dai Longfei D, University Suzhou. Silicon based ice microneedle and preparation method thereof. China Patent CN114588527A; 2022 June 7.

Hongliang Q, Mujiao H, Qihang L, Yuhong M, Wei C, Dechun H. Chinese pharmacology university double response double layer cross-linked insulin controllable delivery microneedle and preparation method thereof, CN114569706A; 2022 Jun 6.

Zeng Xiaowei Z, Yang Yao Y, Hu Jingwen H, Huang Ping H, Yang Li Y, Hou Ailin H, Lin Jiachan, Medium Mountain Uuniversity. Rapid separation type liposome composite sustained-release microneedle and preparation method thereof. China Patent CN114569583A; 2022 March 8.

Yoonsik K, Jiyeon I, Jaehong E, Booyong L, Donghwan K. Kang bokki; southern hospital of Southern medical university. A method for manufacturing a microneedle. Korea Patent KR102427901B1; 2022 Mar 8.

Cuiping Z, Xu L, Zhaobin L, Daewoong Therapeutics. Microneedle array enzyme composite electrode and preparation method thereof. China Patent CN114569124A; 2022 Aug 2.

Hu Ping H, Liu Yang L, Fan Lihong F, Zhang Xingui Z, Chen Tiantian C, Tong Zexin, University Wuhan Tech. Macromolecular soluble microneedle patch and preparation method thereof. China Patent CN114515267A; 2022 May 20.

Zhao Yuanjin Z, Zhang Xiaoxuan Z, Cheng Yi C, Zhang Dagan Z, Shang Yixuan S, Nanjing Tympanic Building Hospital. Composite microneedle balloon and preparation method thereof. China Patent CN114470341A; 2022 March 2.

Lee Sung Guk LS, Leng Gang L, Ma Yonghao M, Yang Jian Y, Youmicro Pearl Ha YP, Biotechnology Co Ltd. Microneedle female die, preparation process of microneedle female die, microneedle patch and preparation process of microneedle patch. China Patent CN114454392A; 2022 Jan 28.

Li Yingli L, Liao Sizhao L, Su Wenhua S, Zhao Pengyue Z, Li Xue L, Yang Meiqing Y, Gao Na, Zhou Lili, Shenzhen Hospital of Southern Medical University. Device for delivery of drug to meibomian glands. China Patent CN114081716A; 2022 Jan 22.

Wang Jianhao W, Lei Xiaoling L, Zhou Xinpei Z, Li Mengjin L, Qiu Lin Q, Zhou Shuwen Z, Cui Pengfei, Wang Cheng, Gao Zihan, University Changzhou. Bacteria responsive microneedle patch as well as preparation method and application thereof. China Patent CN114432276A; 2022 Jan 27.

Wang Ruibing W, Zhang Qingwen Z, Wang Zeyu W, Australia University. Dissoluble microneedle containing active microalgae, microneedle patch, preparation method and application. China Patent CN114557954A; 2022 March 3.

Pei Haifeng P, Mou Dong M, Peng Ke P, Wang Zhen W, Wang Xiong W, Wang Peng W, Li Jing, Military, Western War Area General Hospital For Chinese People Liberation. Novel double-layer medicine balloon. China Patent CN114569868A; 2022 June 3.

Vasilii Z, Andrei P, Microneedles Inc. Microneedle immunotherapeutic multi-component system and a method for vaccination. US Patent US2022023605. Vol. A1; 2022, Jan 27.

Sobin C. Aquavit pharmaceuticals Inc [US]. Methods and compositions for microflillng the skin with hyaluronic acid using microchannel technology. US Patent US2022257494. Vol. A1; 2022, Aug 18.

Marc A, Peyton H, Jan Joo L, Erik L, Bharat P, Emanuel M. Johnson and Johnson Consumer Inc. Microneedle arrays and methods for making and using. US Patent US2022111189. Vol. A1; 2022, Apr 14.

Aykut A, Lalwani Anil K, Kysar Jeffrey W. West alan. University Columbia. Microneedles to deliver therapeutic agent across membranes. US Patent US2022176096. Vol. A1; 2022, Jun 9.

Ali T, Derakhshandeh Hossein MP, University Nebraska. Drug delivery using microneedle arrays. US Patent US2022273926. Vol. A1; 2022, Sep 1.

Jung JH, Jin SG. Microneedle for transdermal drug delivery: current trends and fabrication. J Pharm Investig. 2021;51(5):503-17. doi: 10.1007/s40005-021-00512-4, PMID 33686358.

Aldawood FK, Andar A, Desai S. A comprehensive review of microneedles: types, materials, processes, characterizations and applications. Polymers. 2021;13(16):2815. doi: 10.3390/polym13162815, PMID 34451353.

Kaur B, Thakur N, Goswami M. Evaluating the impact of solid microneedles on the transdermal drug delivery system for Ɣ-Oryzanol. International Journal of Applied Pharmaceutics. 2022;14(6):34-41.

Lakshmı VL, MS U, MA. An assessment on Buccal mucoadhesive drug delivery system. Int J Appl Pharm. 2021 Nov 7:13(6):66-74.

Pund A, Magar M, Ahırrao Y, Chaudharı A, Amrıtkar A. 3D printing technology: A customized advanced drug delivery. Asian J Pharm Clin Res. 2022 Aug 7;15(8):323-33. doi: 10.22159/ajpcr.2022.v15i8.45136.

Kamaraj R, Manju M. Biosimilar current status in India. Asian J Pharm Clin Res. 2017 Jan 1;10(1):25-8. doi: 10.22159/ajpcr.2017.v10i1.14814.

MNJ, Chandrakala V, Srinivasan S. An overview: recent development in transdermal drug delivery. Int J Pharm Pharm Sci. 2022 Oct 1;14(10):1-9.

Dukare MV, Saudagar RB. Needle-free injection system. Int J Curr Pharm Sci. 2018 Mar. 15;10(2):17-24. doi: 10.22159/ijcpr.2018v10i2.25885.

ESPACENET-Patent search; 2023. Available from: Espacenet–patent search. [Last accessed on 16 Jan 2023]



How to Cite

KAUR, B., THAKUR, N., & GOSWAMI, M. (2023). MICRONEEDLES A POSSIBLE SUCCESSOR TECHNOLOGY FOR TDDS: A PATENT ANALYSIS. International Journal of Applied Pharmaceutics, 15(2), 10–22. https://doi.org/10.22159/ijap.2023v15i2.47076



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