ETHOSOMES CARRYING ETODOLAC-EFFECTIVE DRUG CARRIER AS TOPICAL DOSAGE FORM IN THE TREATMENT OF RHEUMATOID ARTHRITIS
DOI:
https://doi.org/10.22159/ijap.2025v17i1.52153Keywords:
Etodolac, Ethosomes, Carbopol 940, Topical, Rheumatoid arthritisAbstract
Objective: The priority-based objective of this research was to develop and evaluate the etodolac loaded Ethosomes as topical delivery in Rheumatoid Arthritis autoimmune disease.
Methods: The ethosomes (EE1-EE6) were prepared with varied concentrations (10%-60% v/v) of ethanol by using Rotary evaporator. The prepared Ethosomes evaluated for %EE (Entraptment Efficiency), Zeta potential, SEM (Scanning Electron Microscopy), TEM (Transmission Electron Microscopy), Vesicle size, In vitro release, In vivo study, Irritancy test, stability test etc.
Results: Prepared ethosomes analysed for zeta potential, vesicle size and % entrapment efficiency and ranges are found to be-18.50mV to-64.53mV, 166.66 nm to 848.97 nm and 53.15% to 89.35%, respectively. Furthermore, when these ethosomes were incorporated in Carbopol 940 gels (EEC1-EEC6), it evaluated for appearance, spredability, pH, viscosity study, drug content and In vitro drug release. All ethosomal gels show satisfactory results. After optimization of ethosomes (EE1-EE6) and ethosomal gels (EEC1-EEC6) on previous criteria, optimised formulations EE4 and EEC4 characterised for SEM, TEM, Ex-vivo permeation, Irritancy, In vivo and different analytical evaluation. The values of r2 were found higher for the first-order model and Korsmeyer-Peppas model for all formulations. Irritancy test shows safe use of formulation and in vivo test shows that EEC4 had a significant inhibitory effect on edema, which was developed in the right paw of rat by injecting carrageenan when it compared with plain Carbopol gel and marketed formulation.
Conclusion: The present study has confirmed that the formulated Etodolac Ethosomal gel can be used as best vehicle for topical administration, which may be used for the management of rheumatoid arthritis.
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