COMPARATIVE ANALYSIS OF TEN MADHURSKANDHA DRUGS DELINEATED IN CHARAKASAMHITA W.S.R TO ADAPTOGENIC AND ANTIOXIDANT ACTIVITIES
Objective: Acarya Caraka had classified Asthapana bastidravya (corrective enema) based on Rasa (Taste), called as Rasaskandha (a group of drugs having similar taste). He ascertained some criteria to include drugs in the group such as drug having either similar Rasa (taste) or Vipaka (biotransformation) or Prabhava (principle responsible for a specific action). The Rasayana Karma of Madhuraskandha dravyas which possess either Madhurarasa or Madhuravipaka and Madhuraprabhava requires scientific validation to determine the skandha classification. Keeping this in view, the study was planned to evaluate Rasayana karma of Madhuraskandha drugs for their adaptogenic and in vivo antioxidant activities.
Methods: Ten selected drugs from Madhuraskandha were conveniently formulated into three Groups A, B, C and used in powder form to evaluate for pharmacological activities. Adaptogenic activity of powders of Madhuraskandha drugs against swimming induced hypothermia was evaluated. In vivo antioxidant activity was assessed by enzymatic assay. The data were analyzed by parametric test i.e. student paired and Unpairedâ€˜tâ€™ test and ANOVA followed by Dunnettâ€˜tâ€™ test.
Results: Adaptogenic activity of drugs was assessed on the basis of reduction in hypothermia, body weight, physical activity in terms of cage rotations, sr. corticosterone, and total protein level. In vivo antioxidant activity carried out by measuring Catalase, Glutathione peroxidase, lipid peroxidation, and superoxide dismutase enzymes assay and tabulated in MeanÂ±SEM format.
Conclusions: The ten selected drugs of Madhuraskandha possess weak to moderate Rasayana (adaptogenic and in vivo antioxidant) activity either through Madhurarasa or vipaka or Madhuraprabhava. The result obtained in the present study may help to boost the Carakaâ€™s Rasaskandha classification. Madhuraskandha drug can be used as natural source of antioxidants as they are attributed with Rasayana Karma.
Key-words: Madhuraskandha, Adaptogenic activity, Antioxidant activity
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