IN VITRO BEHAVIOUR OF PLASMODIUM FALCIPARUM STRAINS BY ALKALOIDS AND TANNINS EXTRACTED FROM ROOT OF MITRAGYNA INERMIS, A MEDICINAL PLANT


Kumulungui Brice Serge, Ondo-azi Alain Serges, Mewono Ludovic, Otogo N’nang Elvis, Akagah Bernardin, Fumoux Francis, TraorÉ Alfred

Abstract


Objective: Mitragyna inermis (Willd.) O. Ktze is a plant belonging to the Rubiaceae family. It is used in West Africa by traditional healers for treatment of accesses febrile generally bound to access malaria, but also to treat several other pathologies. We have collected a medicinal plant, Mitragyna inermis root, currently used for malaria treatment in Burkina-Faso.

Methods: Alkaloids and Tannins were extracted by using conventional methods and antimalarial activities were tested.

Results: After extracted Alkaloids and Tannins, the in vitro culture of Plasmodium falciparum strain isolated from infected patients showed that the alkaloids extracts presented an excellent antiplasmodial activity on P. falciparum strain (IC50 = 2.36 and 2.56 µg/ml respectively) after 24 and 48h of incubation at 37 °C. On the other hand, the tannins extract no presented antiplasmodial activity (IC50>100 µg/ml) but presented an important maturity of P. falciparum strains, letting foretell a possible use of the polyphenolic compounds by P. falciparum as a source of cellular carbon and energy.

Conclusion: These results although exploratory are of fundamental importance for the research in biochemistry and medicine for find new antimalarial prototypes.

Keywords: Mitragyna inermis, Malaria, Roots, Tannins, Alkaloids, Plasmodium falciparum.

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About this article

Title

IN VITRO BEHAVIOUR OF PLASMODIUM FALCIPARUM STRAINS BY ALKALOIDS AND TANNINS EXTRACTED FROM ROOT OF MITRAGYNA INERMIS, A MEDICINAL PLANT

Date

07-01-2016

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 8, Issue 1, 2016 Page: 24-27

Online ISSN

0975-7066

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Authors & Affiliations

Kumulungui Brice Serge
Laboratoire de Sciences des Aliments-URAB, Université des Sciences et Techniques de Masuku. BP 941, Franceville, Gabon

Ondo-azi Alain Serges
Laboratoire de Sciences des Aliments-URAB, Université des Sciences et Techniques de Masuku. BP 941, Franceville, Gabon

Mewono Ludovic
Laboratoire d’Immunologie, de Microbiologie Appliquée et d’Hygiène, Ecole Normale Supérieure, B. P. 440 Libreville, Gabon

Otogo N’nang Elvis
Laboratoire Alpha Chemica, Faculté de Pharmacie, Université Paris-Sud 11, Paris, France

Akagah Bernardin
Laboratoire Alpha Chemica, Faculté de Pharmacie, Université Paris-Sud 11, Paris, France

Fumoux Francis
Pharmacogénétique des Maladies parasitaires, EA 864, IFR 48, Faculté de Pharmacie, Université de la Méditerranée, Marseille cedex 5, France

TraorÉ Alfred
Centre de Recherche en Sciences Biologiques, Alimentaires et Nutritionnelles, Laboratoire de Biotechnologie, Université de Ouagadougou 03 BP7131 Ouagadougou Burkina Faso


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