SYNTHESIS OF TETRA-SUBSTITUTED IMIDAZOLE DERIVATIVES BY CONDENSATION REACTION USING ZEOLITE H-ZSM 22 AS A HETEROGENEOUS SOLID ACID CATALYST


Sami Ullah Bhat, Rawoof Ahmad Naikoo, Muzzaffar Ahmad Mir, Radha Tomar

Abstract


Objective: The present work deals with the synthesis of tetrasubstituted imidazoles using environmentally benign and green catalyst H-ZSM-22.

Methods: The synthesized catalyst was characterized by FTIR, XRD and the products by FTIR and NMR.

Results: H-ZSM-22 has been used as an efficient catalyst for an improved and rapid synthesis of 1,2,4,5 tetrasubstituted imidazoles derivatives using reactants: Benzil, Aldehydes, Amines and Ammonium acetate having excellent yield under solvent conditions. Different derivatives of aldehyde have been used in this reaction. For all the synthesized derivatives, ambient reaction time was found to be of 15-30 min.

Conclusion: The main advantage of this reaction is small reaction time, high purity yield, easy work-up and pollution free.

Keywords: H-ZSM-22, One-pot synthesis, Multi-component reaction, Tetra-substituted imidazoles.

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About this article

Title

SYNTHESIS OF TETRA-SUBSTITUTED IMIDAZOLE DERIVATIVES BY CONDENSATION REACTION USING ZEOLITE H-ZSM 22 AS A HETEROGENEOUS SOLID ACID CATALYST

Date

07-01-2016

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 8, Issue 1, 2016 Page: 36-39

Online ISSN

0975-7066

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Authors & Affiliations

Sami Ullah Bhat
School of Studies in Chemistry, Jiwaji University, Gwalior (M. P.) 474011

Rawoof Ahmad Naikoo
School of Studies in Chemistry, Jiwaji University, Gwalior (M. P.) 474011

Muzzaffar Ahmad Mir
School of Studies in Chemistry, Jiwaji University, Gwalior (M. P.) 474011

Radha Tomar
School of Studies in Chemistry, Jiwaji University, Gwalior (M. P.) 474011


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