• P. Sireesha Department of pharmaceutics, Oil Technological Research Institute, Anantapuram, A. P 515001
  • R. Kiranjyothi Department of pharmaceutics, Oil Technological Research Institute, Anantapuram, A. P 515001


Fluxetine, orodispersible tablets, Crosscarmellose, Crospovidone, Sodium starch glycolate


Objective: Orodispersible tablet formulation was proposed to be developed for fluoxetine hydrochloride taking into consideration it's physical, chemical, pharmacological and pharmacokinetic properties and was proposed to be investigated with respect to its potential to be developed into novel drug delivery system

Methods: Carrying out pre-formulation studies such as drug-polymer interaction analysis by Fourier Transform Infrared (FTIR) spectroscopy and pre-compression characterization of a physical mixture of drug and excipients. Preparation of the orodispersible tablet by using various super disintegrants like croscarmellose, crospovidone & sodium starch glycolate. Preparation of the orodispersible tablet by using various methods like wet granulation method & sublimation method.

Results: To evaluate tablets for various physicochemical parameters such as hardness, friability, weight variation, drug content, wetting time, in vitro disintegration time, in vitro dissolution.

Conclusion: Finally concluded that the oro dispersible tablet of fluoxetine hydrochloride formulated by sublimation method by using crospovidone at 4.5% level used for depression treatment.


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How to Cite

Sireesha, P., and R. Kiranjyothi. “FORMULATION AND EVALUATION OF ANTIDEPRESSANT ORODISPERSIBLE TABLETS”. International Journal of Current Pharmaceutical Research, vol. 8, no. 2, Apr. 2016, pp. 52-60,



Original Article(s)