MODIFIED KONDAGOGU GUM AS MATRIX FORMING MATERIAL FOR SUSTAINED-RELEASE
Objective: To develop sustained release matrix tablets of Tizanidine HCl using modified kondagogu gum.
Methods: Modified kondagogu gum was prepared by cross-linking kondagogu gum with sodium chloride, barium chloride, calcium chloride and sodium tripolyphosphate which was used as a crosslinker. Matrix tablets of Tizanidine HCl were prepared using unmodified kondagogu gum and modified kondagogu gum. The matrix tablets were evaluated for pharmacy technical properties and in vitro release.
Results: Tablets formulated with modified kondagogu gum showed higher mean dissolution time (MDT) and lower dissolution efficiency than those prepared with kondagogu gum. Percentage weight variation, percent friability and content of active ingredient for the prepared colon targeting tablets were found to be well within limits. In vitro release studies for prepared sustained release tablets were carried out for 2 h in pH 1.2 HCl buffer and 6 h in pH 7.4 phosphate buffer. A series of kondagogu gum based tablets were prepared for sustained release. FTIR studies confirmed that there was no chemical interaction between the drug and the polymers in modified kondagogu gum formulation.
Conclusion: The results of the study demonstrate that modified kondagogu gum is a potential matrix material for formulating suitable sustained-release matrix tablets of Tizanidine HCl.Keywords: kondagogu gum, Tizanidine HCl, Sodium tripolyphosphate, Matrix tablets Sustained release
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