MODIFIED KONDAGOGU GUM AS MATRIX FORMING MATERIAL FOR SUSTAINED-RELEASE


Priyanka Singh, Shailendra K Laryia

Abstract


Objective: To develop sustained release matrix tablets of Tizanidine HCl using modified kondagogu gum.

Methods: Modified kondagogu gum was prepared by cross-linking kondagogu gum with sodium chloride, barium chloride, calcium chloride and sodium tripolyphosphate which was used as a crosslinker. Matrix tablets of Tizanidine HCl were prepared using unmodified kondagogu gum and modified kondagogu gum. The matrix tablets were evaluated for pharmacy technical properties and in vitro release.

Results: Tablets formulated with modified kondagogu gum showed higher mean dissolution time (MDT) and lower dissolution efficiency than those prepared with kondagogu gum. Percentage weight variation, percent friability and content of active ingredient for the prepared colon targeting tablets were found to be well within limits. In vitro release studies for prepared sustained release tablets were carried out for 2 h in pH 1.2 HCl buffer and 6 h in pH 7.4 phosphate buffer. A series of kondagogu gum based tablets were prepared for sustained release. FTIR studies confirmed that there was no chemical interaction between the drug and the polymers in modified kondagogu gum formulation.

Conclusion: The results of the study demonstrate that modified kondagogu gum is a potential matrix material for formulating suitable sustained-release matrix tablets of Tizanidine HCl.

Keywords: kondagogu gum, Tizanidine HCl, Sodium tripolyphosphate, Matrix tablets Sustained release

| PDF | HTML |

References


W Cottrell, KS Kang, P Kovaca. Handbook of water soluble gums and resins. In: RL Davidson. ed. McGraw-Hill, Kingsport Press: New York; 1980. p. 24-9.

Hoffman. Pharmacodynamic aspects of sustained release preparations. Adv Drug Delivery Rev 1998;33:185-99.

Brahma N Singh, Kwon H Kim. Floating drug delivery systems: An approach to oral controlled drug delivery via gastric retention. J Controlled Release 2000;63:235-59.

Shweta Arora, Kaved Ali, Alka Ahuja, Roop K Khar, Sanjula Babota. Floating drug delivery systems: a review. AAPS PharmSciTech 2005;6:372-90.

VTP Vinod, RB Sashidhar, VUM Sarma, UVR Vijaya Saradhi. Compositional analysis and rheological properties of gum kondagogu (Cochlospermum gossypium): a tree gum from India. J Agric Food Chem 2008;56:2199–207.

VTP Vinod, RB Sashidhar, B Sreedhar. Biosorption of nickel and total chromium from aqueous solution by gum kondagogu (Cochlospermum gossypium): A carbohydrate biopolymer. J Hazard Mater 2010;178:851–60.

P Saravanan, VTP Vinod, B Sreedhar, RB Sashidhar. Gum kondagogu modified magnetic nano-adsorbent: An efficient protocol for removal of various toxic metal ions. J Mater Sci Eng A 2012;32:581–6.

Valluru Ravi, TM Pramod Kumar. Investigation of kondagogu gum as a pharmaceutical excipient: a case study in developing floating matrix tablet. Int J PharmTech Res 2013;5:70-8.

Ashok Kumar, Munish Ahuja. Carboxymethyl gum kondagogu–chitosan polyelectrolyte complex nanoparticles: preparation and characterization. Int J Biol Macromol 2013;62:80-4.

R Cushman, JW Schick. Modified natural gums, U. S. Patent US 3891620; 1975.

Guk-Hee Suh. Modeling the cost-effectiveness of galantamine for mild to moderately severe Alzheimer's disease in Korea. Value Health 2009;12:S49-S54.

Rajat Ray, Siddhartha Maity, Sanchita Mandal, Tapan K Chatterjee, Biswanath Sa. Development and evaluation of a new interpenetrating network bead of sodium carboxymethyl xanthan and sodium alginate for ibuprofen release. Pharmacol Pharm 2010;1:9-17.

R Cushman, JW Schick. Modified natural gums, U. S. Patent US 3891620; 1975.

NA Peppas. Analysis of fickian and non-fickian drug release from polymers. Pharm Acta Helv 1985;60:110-1.




About this article

Title

MODIFIED KONDAGOGU GUM AS MATRIX FORMING MATERIAL FOR SUSTAINED-RELEASE

Date

01-07-2016

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 8, Issue 3, 2016 Page: 82-87

Online ISSN

0975-7066

Statistics

33 Views | 258 Downloads

Authors & Affiliations

Priyanka Singh
Department of Pharmaceutics, Pacific Academy of Higher Education and Research University, Udaipur, India

Shailendra K Laryia


Refbacks

  • There are currently no refbacks.