EVALUATION OF ANTIDEPRESSANT ACTIVITY OF ETHANOLIC EXTRACT OF DIPTERCANTHUS PROSTRATUS NEES

  • Prasanth Nv Al Shifa College of Pharmacy, Poonthavanam PO, Perinthalmanna, Malappuram dt. Kerala, 679325
  • Jaseem Sabith K
  • Sanal Dev Kt
  • Sajeev V Kumar

Abstract

Objective: The major objective of the study is to evaluate the antidepressant activity of ethanolic extract of Dipteracanthus prostratus Nees using rats. The study also aims to assess the effect of the extract on behavioural pattern of treated rats.

Methods: The antidepressant activity of the ethanolic extract of Dipteracanthus prostratus was evaluated using Forced swim test (FST). The effect of the extract on the behavioral pattern was assesssed by an Open field test. The oral doses of 500 mg/kg and 250 mg/kg of the extract were fixed after conducting acute toxicity studies. Imipramine (30 mg/kg) was used as the standard.

Results: It was observed from the study that the ethanolic extract of Dipteracanthus prostratus at higher concentration showed significantly (p<0.01) reduction in immobility in forced swim test model of depression after repeated administration for 14 d. The results were comparable to the standard drug Imipramine. However, the extract did not any significant activity after acute administration. Neither the ethanolic extract of Dipteracanthus prostratus nor the standard drug imipramine produced any overt behavioural change or motor dysfunction in the open field test.

Conclusion: The present study demands a further detailed investigation on the antidepressant and other possible CNS activities of Dipteracanthus prostrates.

Keywords: Antidepressant, Dipteracanthus prostrates, Forced swim test

References

1. Santosh P, Venugopl R, Nilakash AS, Kunjbihari S, Mangala L. Antidepressant activity of methanolic extract of Passiflora foetida leaves in mice. Int J Pharm Pharm Sci 2011;3:112­1.
2. Kumar U, Sagar R, Bhandari A, Srivastava AK. Evaluation of anti-inflammatory activity of methanolic and toluene extract of Dipteracanthus prostratus nees. Int J Pharmacogn Phytochem Res 2015;7;435-9.
3. Ganapathiraman, Palanivelu M, Sathis Ksumar D, Sravan prasad, Suresh Kumar P, Hematheerthani N, et al. Extraction, fractionation and pharmacological activity of Dipteracanthus prostratus (Poir) Nees. Asian J Chem 2012;24:461-4.
4. Banu Rekha J, Ruby S, Jaykar B. Anticancer activity of aqueous and ethanolic extracts of the whole plant of Dipteracanthus prostratus Nees. Asian J Pharm Anal Med Chem 2014;2:208-13.
5. Buttereck V, Nishibe S, Sasaki T, Uchida M. Antidepressant effect of Apocynum venteum in a forced swim test. Biol Pharm Bull 2001;24:848-51.
6. Ashok Kumar BS, Lakshman K, Velmurugan C, Sridhar SM, Gopisetty Saran. Antidepressant activity of methanolic extract of Amaranthus Spinosus. Basic Clin Neurosci 2014;5:11-7.
7. OECD: Guidelines for testing of chemicals: acute oral toxicity, environmental health and safety monograph series on testing and adjustment; 2001. p. 425.
8. Lieh-Ching Hsu, Yu-Jen Ko, Hao-Yuan Cheng, Ching-Wen Chang, Yu-Chin Lin, Ying-Hui Cheng, et al. the Antidepressant-like activity of the ethanolic extract from Uncarialanosa wallichvar appendiculata ridsd in the forced swimming test and in the tail suspension test in mice. J Evidence-Based Complementary Altern Med 2012;1:1-12.
9. Porsolt RD, Anton G, Blavet N, Jalfre M. Behavioural despair in rats: a new model sensitive to antidepressant treatments. Eur J Pharmacol 1978;47:379-91.
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How to Cite
Nv, P., J. S. K, S. D. Kt, and S. V. Kumar. “EVALUATION OF ANTIDEPRESSANT ACTIVITY OF ETHANOLIC EXTRACT OF DIPTERCANTHUS PROSTRATUS NEES”. International Journal of Current Pharmaceutical Research, Vol. 8, no. 3, July 2016, pp. 93-95, https://innovareacademics.in/journals/index.php/ijcpr/article/view/13903.
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