• Chittakath Shaima Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641046, Tamil Nadu, India
  • Puthamohan Vinayaga Moorthi Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641046, Tamil Nadu, India
  • Shaheen Naser Kutty Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641046, Tamil Nadu, India



Nil, Chitosan nanoparticle, IC50 values, SEM, Anticancer activity


Objective: 5' Fluorouracil (5'FU) loaded chitosan nanoparticle (5FCN) was synthesized and tested for its anticancer activity against Hep G2, the liver cancer cell line.

Methods: The morphological characteristic of the 5FCN was visualized in Scanning Electron Microscope (SEM).

Results: The 5FCN revealed an IC50 value of 49.50 µl/ml. The study revealed that the 5FCN exhibited excellent anticancer activity against Hep G2 cell line which can be further studied for its application in cancer treatment.

Conclusion: Further studies would be focused onto report the drug release efficiency under different physiological conditions and evaluate them in animal model.


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How to Cite

Shaima, C., P. V. Moorthi, and S. N. Kutty. “IN VITRO ANTICANCER ACTIVITY OF 5’ FLUO URACIL COATED CHITOSAN NANOPARTICLE”. International Journal of Current Pharmaceutical Research, vol. 8, no. 4, Oct. 2016, pp. 6-8, doi:10.22159/ijcpr.2016v8i4.15267.



Original Article(s)