IN VITRO ANTICANCER ACTIVITY OF 5’ FLUO URACIL COATED CHITOSAN NANOPARTICLE


Chittakath Shaima, Puthamohan Vinayaga Moorthi, Shaheen Naser Kutty

Abstract


Objective: 5’ Fluorouracil (5’FU) loaded chitosan nanoparticle (5FCN) was synthesized and tested for its anticancer activity against Hep G2, the liver cancer cell line.

Methods: The morphological characteristic of the 5FCN was visualized in Scanning Electron Microscope (SEM).

Results: The 5FCN revealed an IC50 value of 49.50 µl/ml. The study revealed that the 5FCN exhibited excellent anticancer activity against Hep G2 cell line which can be further studied for its application in cancer treatment.

Conclusion: Further studies would be focused onto report the drug release efficiency under different physiological conditions and evaluate them in animal model.


Keywords


5’Fluorouracil, Chitosan nanoparticle, IC50 values, SEM, Anticancer activity

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About this article

Title

IN VITRO ANTICANCER ACTIVITY OF 5’ FLUO URACIL COATED CHITOSAN NANOPARTICLE

Keywords

5’Fluorouracil, Chitosan nanoparticle, IC50 values, SEM, Anticancer activity

DOI

10.22159/ijcpr.2016v8i4.15267

Date

18-10-2016

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 8, Issue 4, 2016 Page: 6-8

Online ISSN

0975-7066

Statistics

69 Views | 161 Downloads

Authors & Affiliations

Chittakath Shaima
Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641046, Tamil Nadu, India
India

Puthamohan Vinayaga Moorthi
Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641046, Tamil Nadu, India
India

Shaheen Naser Kutty
Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641046, Tamil Nadu, India
India


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