ELECTROANALYSIS OF IBUPROFEN ON CONDUCTING POLYANILINE NANOFIBER COATED GLASSY CARBON SURFACE


E. Suresh, K. Sundaram, B. Kavitha, N. Senthil Kumar

Abstract


Objective: Voltammetric procedure for analysis of pharmaceutical formulation of ibuprofen on conducting polyaniline nanofiber modified glassy carbon electrode was explored.

Methods: The effect of pH was studied at different medium such as acidic, neutral and basic. The cyclic voltammetric behavior of ibuprofen was studied between−0.5 V and 1.8 V versus Ag/AgCl at modified glassy carbon surface.

Results: The electroanalytical parameters of the detection are highly dependent on their configuration and dimensions of the electrode. The scan rate and concentration effect of ibuprofen were studied. The best limit of detection was 100 ppb and the linear range from 200 to 400 ppb on the modified electrode surface. The determination was successfully applied for the detection of drugs in several pharmaceutical drug formulations. The Atomic force microscopic (AFM) image shows the surface morphologies of polymer modified surface; compound adsorbed surface, particle distribution graphs and surface roughness values, which are in good agreement.

Conclusion: The anodic peak was observed at 1.63 V, assigned for the oxidation of ibuprofen, which is not accompanied by corresponding cathodic reduction. This behavior suggested that the irreversibility of the electrode process.

Keywords


Ibuprofen, Voltammetry, Nanostructure, Nanofiber, Polyaniline, Differential Pulse Voltammetry, AFM

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About this article

Title

ELECTROANALYSIS OF IBUPROFEN ON CONDUCTING POLYANILINE NANOFIBER COATED GLASSY CARBON SURFACE

Keywords

Ibuprofen, Voltammetry, Nanostructure, Nanofiber, Polyaniline, Differential Pulse Voltammetry, AFM

DOI

10.22159/ijcpr.2016v8i4.15276

Date

18-10-2016

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 8, Issue 4, 2016 Page: 44-48

Online ISSN

0975-7066

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Authors & Affiliations

E. Suresh
Department of Chemistry, Karpagam University, Karpagam Academy of Higher Education, Coimbatore 641021, Tamil Nadu, India

K. Sundaram
Department of Chemistry, Karpagam University, Karpagam Academy of Higher Education, Coimbatore 641021, Tamil Nadu, India

B. Kavitha
Department of Chemistry, Sri Ranganathar Institute of Engineering and Technology, Coimbatore 641110, Tamil Nadu, India
India

N. Senthil Kumar
Department of Chemistry, Arignar Anna Government Arts College, Cheyyar 604407, Tiruvannamalai (Dt.), Tamil Nadu, India


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