SYNTHESIS AND EVALUATION OF ANTI-INFLAMMATORY AND ANTIBACTERIAL ACTIVITIES OF SOME 1, 2-BENZISOXAZOLE DERIVATIVES


Sarath Sasikumar, Haripriya M., Anjali T.

Abstract


Objective: A series of 1, 2-Benzisoxazole derivatives were synthesized and characterized by various analytical techniques like Melting point, Rf, FTIR, and NMR spectra.

Methods: Structures of the compounds were elucidated and evaluated for anti-inflammatory activity by HRBC membrane stabilization method, antibacterial activity against Escherichia coli and Staphylococcus aureus by cup plate method.

Results: The compounds 4a and 4e showed good anti-inflammatory activity compared with standard drug Diclofenac sodium and compounds 4b and 4d showed good antibacterial activity on compared with standard drug Gentamycin.

Conclusion: These compounds may serve as future leads for anti-inflammatory and antibacterial drug discovery.


Keywords


1, 2-Benzisoxazole, Anti-inflammatory, Antibacterial activity

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References


Robert L Findling, Michael G Aman, Marielle Eerdekens, Albert Derivan, Ben Lyons, Long-Term. Open-Label study of risperidone in children with severe disruptive behaviors and below-average IQ. Am J Psychiatry 2004;161:677-84.

Gaetano Zaccara, Luigi M Specchio. Long-term safety and effectiveness of zonisamide in the treatment of epilepsy: a review of the literature. Neuropsychiatr Dis Treat 2009;5:249–59.

Baulac M. The long-term retention of zonisamide in a large cohort of people with epilepsy at a tertiary referral center. Epilepsy Res 2006;2:S3–S9.

Veera Reddy Arava, Udaya Bhaskara Rao Siripalli, Vaishali Nadkarni, Rajendiran Chinnapillai. Novel base-catalyzed rearrangement of sultone oximes to 1, 2-benzisoxazole-3-methane sulfonate derivatives. Beilstein J Org Chem 2007;3:20.

K Madhavi, K Bharathi, KVSRG Prasad. Synthesis and evaluation of 3-methyl-4-nitro-5-(substituted styryl) isoxazoles for antioxidant and anti-inflammatory activities. Res J Pharm Biol Chem Sci 2010;1:1073-82.

Ravindra M Kumbhare, VN Ingle. Synthesis of novel benzothiazole and benzisoxazole functionalized unsymmetrical alkanes and study of their antimicrobial activity. Indian J Chem 2009;48:996-1000.

Vijay kumar Tirlapur, Narasimha Gandhi, Raga Baswaraj, Rajendra Prasad Y. Synthesis, characterization and biological activities of some pyrimidines and isoxazoles bearing benzofuran moiety. Int J ChemTech Res 2010;2:1434-40.

RA Shastri, JS Varudkar. Synthesis and antimicrobial activity of 3-propene 1, 2-benzisoxazole derivatives. Indian J Chem 2009;48B:1156-60.

Varadarasou Mouttaya Mounnissamy, Subrahmanyan Kavimani, Vaithilingam Balu, Sabarimuthu Darlin Quine. Evaluation of anti-inflammatory and membrane stabilizing properties of ethanol extract of Cansjera rheedii J. Gmelin (Opiliaceae). Iranian J Pharmacol Ther 2007;6:235-7.

G Prakash Yoganandam, K Ilango, Sucharita De. Evaluation of anti-inflammatory an membrane stabilizing properties of various extracts of Punica granatum L (Lytheraceae). Int J PharmTech Res 2010;2:1260-3.




About this article

Title

SYNTHESIS AND EVALUATION OF ANTI-INFLAMMATORY AND ANTIBACTERIAL ACTIVITIES OF SOME 1, 2-BENZISOXAZOLE DERIVATIVES

Keywords

1, 2-Benzisoxazole, Anti-inflammatory, Antibacterial activity

DOI

10.22159/ijcpr.2016v8i4.15281

Date

18-10-2016

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 8, Issue 4, 2016 Page: 64-67

Online ISSN

0975-7066

Statistics

66 Views | 48 Downloads

Authors & Affiliations

Sarath Sasikumar
Dept. of Pharmaceutical Sciences, M. G University, Kottayam 686631, Kerala, India
India

Haripriya M.
College of Pharmaceutical Sciences Govt. Medical College, Thiruvananthapuram 695011, Kerala, India
India

Anjali T.
Nehru College of Pharmacy, KUHS University, Thrissur 680597, Kerala, India


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