SYNTHESIS AND EVALUATION OF ANTI-INFLAMMATORY AND ANTIBACTERIAL ACTIVITIES OF SOME 1, 2-BENZISOXAZOLE DERIVATIVES

  • Sarath Sasikumar Dept. of Pharmaceutical Sciences, M. G University, Kottayam 686631, Kerala, India
  • Haripriya M. College of Pharmaceutical Sciences Govt. Medical College, Thiruvananthapuram 695011, Kerala, India
  • Anjali T. Nehru College of Pharmacy, KUHS University, Thrissur 680597, Kerala, India

Abstract

Objective: A series of 1, 2-Benzisoxazole derivatives were synthesized and characterized by various analytical techniques like Melting point, Rf, FTIR, and NMR spectra.

Methods: Structures of the compounds were elucidated and evaluated for anti-inflammatory activity by HRBC membrane stabilization method, antibacterial activity against Escherichia coli and Staphylococcus aureus by cup plate method.

Results: The compounds 4a and 4e showed good anti-inflammatory activity compared with standard drug Diclofenac sodium and compounds 4b and 4d showed good antibacterial activity on compared with standard drug Gentamycin.

Conclusion: These compounds may serve as future leads for anti-inflammatory and antibacterial drug discovery.

Keywords: 1, 2-Benzisoxazole, Anti-inflammatory, Antibacterial activity

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How to Cite
Sasikumar, S., H. M., and A. T. “SYNTHESIS AND EVALUATION OF ANTI-INFLAMMATORY AND ANTIBACTERIAL ACTIVITIES OF SOME 1, 2-BENZISOXAZOLE DERIVATIVES”. International Journal of Current Pharmaceutical Research, Vol. 8, no. 4, Oct. 2016, pp. 64-67, doi:10.22159/ijcpr.2016v8i4.15281.
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