• K. Pallavi G. Pulla Reddy College of Pharmacy, Osmania University
  • T. Pallavi


Objective: The main aim of the present research was to develop an oral fast dissolving polymeric film (FDF) with good mechanical properties, faster disintegration and dissolution when placed on the tongue.

Methods: Eletriptan hydrobromide is prescribed for the treatment of mild to a moderate migraine. The polymers selected for preparing films were Pullulan, Maltodextrin (MDX), Acacia, Sodium alginate (SA), Locust bean gum (LBG), Guar gum (GG), Xanthan gum (XG), Polyvinyl alcohol (PVA), Polyvinyl pyrrolidine (PVP), Hydroxyl propyl methyl cellulose (HPMC) E5, and HPMC E15. Twelve sets of films FN1–FN12 were prepared by solvent casting method with Pullulan and combination of Acacia, MDX, SA, LBG, GG, XG, PVA, PVP, HPMC E5 and HPMC E15. Five sets of films FS1–FS5 were prepared using synthetic polymers like PVA, PVP, HPMC E5 and HPMC E15.

Results: From all the prepared polymer formulations, FN2, FN8, and FS3 were selected based on disintegration time, and drug release and amongst this three FN2 was optimised based on its disintegration time (D. T). The percent drug release of the optimised film was compared with the percent release of the pure drug.

Conclusion: The optimised formulation had a D. T of 16 s and a percent drug release of 97.5% in 10 min in pH 6.8 phosphate buffer and 100.6% drug release in 10 min in 0.1N HCl.

Keywords: oral FDFs, Pediatric, Geriatric, Dysphasia


1. Rasool Hassan. Overview on drug delivery system. Pharm Anal Acta 2012;3:2153-35.
2. Prasana Desu, Manoranjan Sahu. Formulation and evaluation of fast dissolving films of zolmitriptan. Int Res J Pharm 2012;3:373-6.
3. Alpesh Patel R, Dharmendra Prajapati S, Jignyasha Raval A. Fast dissolving films (FDFs) as a newer venture in fast dissolving dosage forms. Int J Drug Dev Res 2010;2:232-46.
4. Dipika Parmar, Upendra Patel, Bhavin Bhimani, Aditi Tripathi, Dhiren Daslania, Ghanshyam Patel. Orally fast dissolving films as a dominant dosage form for quick release. Int J Pharm Res Bio-sci 2012;1:27-41.
5. Suresh B, Halloran D, James L. Quick dissolving films: a novel approach to drug delivery. Drug Dev Tech; 2006. p. 1-7.
6. Samita Gauri, Gaurav Kumar. Fast dissolving drug delivery and its technologies. Pharma Innovation 2012;1:34-9.
7. Swapnil Patil L, Paresh Mahaparale R, Madhavi Shivnikar A, Shradha Tiwari S, Ketan Pawar V, Prashant Sane N. Fast dissolving oral films: an Innovative drug delivery system. Int J Res Rev Pharm Appl Sci 2012;2:482-96.
8. Dixit RP, Puthli SP. Oral strip technology: overview and future potential. J Cont Release 2009;139:94-107.
9. Gowri R, Narayan N, Revathy S, Prabhavathy G, Preethy Mol G, Rekha G. Melt in mouth films–an effective alternative drug delivery system. Int J Biol Pharm Res 2013;4:645-50.
10. Kai Bin Liew, Yvonne Tze Fung Tan, Kok K Khiang Peh. Characterization of oral disintegrating film containing donepazil for the alzhemier disease. AAPS PharmSciTech 2012;13:134-42.
11. Karthikeyan D, Sanju Sri, Santhosh Kumar C. Development of fast dissolving oral film containing rizatriptan benzoate as an antimigraine medication. Indo Am J Pharm Res 2013;3:2642-54.
12. Indian Pharmacopoeia. Vol 2. Delhi: Government of India ministry of health and family welfare; 2014.
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How to Cite
Pallavi, K., and T. Pallavi. “FORMULATION AND EVALUATION OF FAST DISSOLVING FILMS OF ELETRIPTAN HYDROBROMIDE”. International Journal of Current Pharmaceutical Research, Vol. 9, no. 2, Mar. 2017, pp. 59-63, doi:10.22159/ijcpr.2017v9i2.17386.
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