• Kumble Divya Department of Post Graduate Studies and Research in Chemistry, St. Agnes College, Mangaluru 575002, Karnataka, India
  • Geetha M. Pinto Department of Post Graduate Studies and Research in Chemistry, St. Agnes College, Mangaluru 575002, Karnataka, India
  • Asha F Pinto Department of Post Graduate Studies and Research in Chemistry, St. Agnes College, Mangaluru 575002, Karnataka, India


Schiff bases are versatile ligands which are synthesized from the condensation of primary amines with carbonyl groups. Synthesis of Schiff base transition metal complexes by using Schiff base as ligands appears to be fascinating in view of the possibility of obtaining coordination compounds of unusual structure and stability. These transition metal complexes have received exceptional consideration because of their active part in metalloenzymes and as biomimetic model compounds due to their closeness to natural proteins and enzymes. These compounds are very important in pharmaceutical fields because of their wide spectrum of biological activities. Most of them show biological activities including antibacterial, antifungal, antidiabetic, antitumor, antiproliferative, anticancer, herbicidal, and anti-inflammatory activities. The biological activity of the transition metal complexes derived from the Schiff base ligands has been widely studied. This review summarizes the importance, Scope and antimicrobial activities of Schiff base metal complexes.

Keywords: Schiff bases, Metal complexes, Microorganism and antimicrobial activity


1. Shamsipur M, Ghiasvand AR. Solid phase extraction of ultra trace copper(II) using octadecyl silica membrane disks modified by a naphthol derivative schiff’s base. Anal Chim Acta 2000;408:271-7.
2. Reddy KK, Sayaji R, Biyyala SR. Synthesis and characterization and biological activities of hydrazones. Int J Innovative Res Sci Eng Technol 2015;4:18944-52
3. Qiu M, Liu G, Yao X, Guo M, Pan G, Zheng ZC. Copper(II)-schiff base complexes as catalysts for asymmetric cyclopropanation of styrene. Chin J Catal 2001;22:77-80.
4. Zhuo-Hong Yang, Li-Xin Wang, Zheng-Hong Zhou, Qi-Lin Zhou, Chu-Chi Tang. Synthesis of new chiral schiff bases and their application in the asymmetric trimethylsilyl cyanation of aromatic aldehydes. Tetrahedron Asymmetry 2001;12:1579-82.
5. Jose ES, Edward RS, Cavalheirob ETG. Synthesis and characterization of schiff bases from chitosan and salicylaldehyde derivatives. Carbohydrates Polymer 2005;60:277-82.
6. Alexander V. Design and synthesis of macrocyclic ligands and their complexes of lanthanides and actinides. Chem Rev 1995;95:273-342.
7. Quiruga AG, Ranninger CN. Review contribution to the SAR field of metallated and coordination complexes: studies of the palladium and platinum derivatives with selected thiosemicarbazones as antitumoral drugs. Coord Chem Rev 2004;248:119-33.
8. Douglas XW, Anthony E. Thiosemicarbazone complexes of copper(II): structural and biological studies. Coord Chem Rev 1993;123:49-71.
9. Tuo W, Zijian G. Copper in medicine: homeostasis, chelation therapy and antitumor drug design. Curr Med Chem 2006;13:525-37.
10. Lobana TS, Sharma R, Gagandeep B, Sonia K. Bonding and structure trends of thiosemicarbazone derivatives of metals an overview. Coord Chem Rev 2009;253:977-1055.
11. Pietro AV, Sergio T. The challenge of cyclic and acyclic schiff bases and related derivatives. Coord Chem Rev 2004;248:1717–2128.
12. Supuran CT, Barboiu M, Luca C, Pop E, Brewster ME, Dinculescu A. Carbonic anhydrase activators. Part 14. Syntheses of mono and bispyridinium salt derivatives of 2-amino-5-(2-aminoethyl)-and 2-amino-5-(3-aminopropyl)-1,3,4-thiadiazole and their interaction with isozyme II. Eur J Med Chem 1996;31:597-606.
13. Gaur S. Physico-chemical and biological properties of Mn(II), Co(II), Ni(II) and Cu(II) chelates of schiff bases. Asian J Chem 2003;15:250–4.
14. Michael JG, Carolyn B, Barb JK, Steven M. Swaney W, Gary. Novel 1,5-Diphenylpyrazole nonnucleoside hiv-1 reverse transcriptase inhibitors with enhanced activity versus the delavirdine-resistant p236l mutant:   lead identification and SAR of 3-and 4-substituted derivatives. J Med Chem 2005;43:1034-40.
15. Ilknur B, Esin P, Halil B. Synthesis, characterization and antimicrobial activities of vicdioxime derivatives containing heteroaromatic hydrazone groups and their metal complexes. Int J Sci Technol 2013;7:26-41.
16. Ikechukwu Pe, Ajibade PA. Synthesis, characterization and biological studies of metal(ii) complexes of (3E)-3-[(2-{(E)-[1-(2,4-Dihydroxyphenyl) ethylidene]amino}ethyl)imino]-1-phenylbutan-1-one schiff base. Molecules 2015;20:9788-802.
17. Ajay RP, Kamini JD, Raut VR Patil, Lokhande RS. Synthesis, characterization and biological activity of mixed ligand Co(II) complexes of schiff base 2-amino-4-nitrophenol-n-salicylidene with some amino acids. J Chem Pharm Res 2012;4:1413-25.
18. Hemant K, Chaudhary RP. Biological studies of a novel azo based heterocyclic schiff base and its transition metal complexes. Der Chem Sin 2010;1:55-61.
19. Chohana Z, Sajjad HS, Moulay HY, Taibi BH. Metal based biologically active compounds: Design, synthesis, and antibacterial/antifungal/cytotoxic properties of triazole-derived schiff bases and their oxovanadium (IV) complexes. Eur J Med Chem 2010;45:2739-47.
20. Aliasghar J, Dariush E, Chanaz S, Jean MB. Synthesis, antibacterial, antifungal and antiviral activity evaluation of some new bis-schiff bases of isatin and their derivatives. Molecules 2007;12:1720-30.
21. Rajavel R, Enthil MV, Anitha C. Synthesis, physical characterization and biological activity of some schiff base complexes. Eur J Chem 2008;5:620-6.
22. Bernadette SC, Brian D, Denise A, Egana KK, Georgina R. Anticancer and antifungal activity of copper(II) complexes of quinolin-2(1H)-one-derived Schiff bases. Inorganic Chim Acta 2010;363:4048-58.
23. Parasha RK, Sharma RC, Govind M. Biological activity of some schiffbases and their metal complexes. Biol Trace Element Res 1989;23:145-50.
24. Gaowen Y, Xiaoping X, Huan T, Zhao C. Synthesis and antitumor activity of schiff base coordination compounds. Chinese J Appl Chem 1995;12;13-7.
25. Maria CC, Michela B, Alessandro D, Elias M, Antonio P. Synthesis and antimicrobial activity of novel arylideneisothio semicarbazones. Pharmaceutical 2000;55:93-8.
26. Blahova M, Sokolík J, Sedlackova S, Burianova E, Mlynarcik D. Antimicrobial activity of diazole-(N-salicylidene-L-alpha-alaninato)-copper complexes. Ceskoslovenska Farmacie 1993;42:137-40.
27. Blahova M, Tumova M. Anti-inflammatory activity of aqua(aryloxyacetato)copper(II) complexes. Pharmazie 1994;49:373-4.
28. Gladiola T, Mihai N, Lenuta P. Synthesis and biological evaluation of some new schiff bases and their Cu(II) and Mg(ІІ) complexes. Afr J Pharm Pharmacol 2013;7:1225-30.
29. Abhishek K, Fernandes J, Pankaj K. Synthesis, antimicrobial and anti-inflammatory studies of some novel schiff base derivatives. Int J Drug Development Res 2014;6:165-7.
30. Dun E. Antifungal resistance in yeast vaginitis. Yale J Biol Med 1999;72:281–5.
31. Fluit C, Maarten RV, Franz-Josef S. Molecular detection of antimicrobial resistance. Clin Microbiol Rev 2001;14:836-71.
32. Yeaman MR, Yount NY. Mechanisms of antimicrobial peptide action and resistance. Pharmacol 2003;55:27–55.
33. Yousif E, Adil H, Majeed A, Graisa A, Farina Y. Structure and fungicidal activity of some diorganotin(IV) with benzamidophenylalanine. Arabian J Chem 2009;4:39-42.
34. Yousif E, Adil H, Farina Y. Synthesis and characterization of some metal Ions with 2-amino acetate benzothiazole. J Appl Sci Res 2010;6:879-82.
35. Y Win, Yousif E, Majeed A, Ha S. Synthesis, characterization and in vitro antimicrobial activity of Co(II), Cu(II), Zn(II), Cd(II) and Sn(II) ions with {[5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl]thio}acetic acid. Asian J Chem 2011;23:5009–12.
36. Asif NK, Ajay P, Sharad T, Jagannath JK, Lokhande MV. Antibacterial activity of 2-[(2-chloro-4-methylbenzylidene) amino] pyridin-4-ol and its some transitional metal ion complexes. IOSR J Appl Chem 2014;7:14-20.
37. Nazk MA, Shaalanand ND, Sahar S. Synthesis, spectroscopic, thermodynamic and biological activity studies of schiff base and metal complexes derived from 2-[ 1h-pyrrol-2-ylimino methyl]-5-phenyl-1,3,4-oxadiazole. Global J Sci Frontier Res: B Chem 2015;15:14-8.
38. Shridhar SR, Pandeya SN. Synthesis and anti-HIV activity of some isatin derivatives E. De Clercq Ball Chimico Farmaceutico 2001;140:302-5.
39. Pratibha MSJ, Vatsala P, Uma V. Biologically active Co (II), Ni (II), Cu (II) and Mn(II) Complexes of Schiff Bases derived from Vinyl aniline and Heterocyclic Aldehydes. Int J Chem Technol Res 2009;1:225-32.
40. Mehmet G, Mehmet S, Ismet B. Synthesis, characterization, and antimicrobial activity of a new pyrimidine schiff base and its Cu(II), Ni(II), Co(II), Pt(II), and Pd(II) complexes. Turkish J Chem 2012;36:189-200.
41. Rishu K, Harpreeth K, Brij KK. Applications of copper–schiff base complexes: a review. Sci Rev Chem Commun 2013;3:1-15.
42. MB Halli MB, Ravindra SM, Sumathi RB, Shivakumar K. Synthesis, spectroscopic characterization and biological activity studies of schiff base metal complexes derived from N'-(4-(methylthio) benzylidene)benzofuran-2-carbohydrazide. Der Pharm Lett 2013;5:182-8.
43. Ikechukwu PE, Peter AA. Synthesis, characterization and biological studies of metal(ii) complexes of (3E)-3-[(2-{(E)-[1-(2,4-Dihydroxyphenyl) ethylidene]amino}ethyl)imino]-1-phenylbutan-1-one schiff base. Molecules 2015;20:9788-802.
44. Omar BI, Mahmoud AM, Moamen SR. Nano sized schiff base complexes with Mn(II), Co(II), Cu(II), Ni(II) and Zn(II) metals: synthesis, spectroscopic and medicinal studies. Can Chem Trans 2014;2:108-21.
45. Raj K, Sheetal T. Syntheses and biological creening of schiff base complexes of titanium(IV). Chem Eng Transactions 2013;32:1801-6.
46. Mouayed YK, Abduljleel MA. Synthesis, characterization and biological studies of schiff bases derived from piperonal and their complexes with cobalt (II). Der Pharma Chem 2014;6:88-100.
47. Spinu C, Pleniceanu M, Cristian T. Biologically active transition metal chelates with a 2-thiophenecarboxaldehyde derived schiff base: synthesis, characterization, and antibacterial properties. Turkish J Chem 2008;32:487-93.
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How to Cite
Divya, K., G. M. Pinto, and A. F. Pinto. “APPLICATION OF METAL COMPLEXES OF SCHIFF BASES AS AN ANTIMICROBIAL DRUG: A REVIEW OF RECENT WORKS”. International Journal of Current Pharmaceutical Research, Vol. 9, no. 3, May 2017, pp. 27-30, doi:10.22159/ijcpr.2017.v9i3.19966.
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