FORMULATION AND EVALUATION OF CHEWABLE MULTIVITAMIN TABLET


Sabina Akhtar, Pulak Dev

Abstract


Objective: The overall objective of the present study was to formulate the chewable multivitamin tablet prepared by direct compression method.

Methods: The excipient used in this study are mannitol, sucrose, starch, talc, magnesium stearate, vanilla powder for the effective formulation. As it is multivitamin, ascorbic acid, riboflavin, nicotinamide, thiamine HCL are used and evaluated for precompression parameter. The chewable tablets were better presented using sweetener sucrose and vanilla powder as a flavouring agent. The formulated tablet was evaluated for post compression parameter. The chewable tablet are prepared to ensure that they are easily crushed by chewing. The tablet was evaluated for weight variation, hardness, thickness, friability, drug content. Their dissolution properties were assessed using USP (paddle apparatus).

Conclusion: From the above study, we conclude that the chewable tablets were prepared by direct compression method and gave the satisfactory and acceptable result. The tablet shows immediate drug release due to direct compressed tablet

Results: All the parameter were found within the specification. Drug content of ascorbic acid (103.62%-108.84%), riboflavin (99.88%-112.02%), nicotinamide (93.44%-100.31), thiamine Hcl (105.94%-108.5%) were found.


Keywords


Multivitamin, Ascorbic acid, Riboflavin, Nicotinamide, Thiamine HCL, Direct compression, Chewable tablet

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About this article

Title

FORMULATION AND EVALUATION OF CHEWABLE MULTIVITAMIN TABLET

Keywords

Multivitamin, Ascorbic acid, Riboflavin, Nicotinamide, Thiamine HCL, Direct compression, Chewable tablet

DOI

10.22159/ijcpr.2017v9i4.20958

Date

14-07-2017

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 9, Issue 4, 2017 Page: 61-64

Online ISSN

0975-7066

Statistics

145 Views | 62 Downloads

Authors & Affiliations

Sabina Akhtar
Girijananda Chowdhury Institute of Pharmaceutical Science, Azara, Hatkhowapara, Guwahati-17

Pulak Dev
2Depertment of Pharmaceutical Science, Girijananda Chowdhury Institute of Pharmaceutical Science, Azara, Hatkhowapara, Guwahati-17


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