• Sabina Akhtar Girijananda Chowdhury Institute of Pharmaceutical Science, Azara, Hatkhowapara, Guwahati-17
  • Pulak Dev 2Depertment of Pharmaceutical Science, Girijananda Chowdhury Institute of Pharmaceutical Science, Azara, Hatkhowapara, Guwahati-17


Objective: The overall objective of the present study was to formulate the chewable multivitamin tablet prepared by direct compression method.

Methods: The excipient used in this study are mannitol, sucrose, starch, talc, magnesium stearate, vanilla powder for the effective formulation. As it is multivitamin, ascorbic acid, riboflavin, nicotinamide, thiamine HCL are used and evaluated for precompression parameter. The chewable tablets were better presented using sweetener sucrose and vanilla powder as a flavouring agent. The formulated tablet was evaluated for post compression parameter. The chewable tablet are prepared to ensure that they are easily crushed by chewing. The tablet was evaluated for weight variation, hardness, thickness, friability, drug content. Their dissolution properties were assessed using USP (paddle apparatus).

Conclusion: From the above study, we conclude that the chewable tablets were prepared by direct compression method and gave the satisfactory and acceptable result. The tablet shows immediate drug release due to direct compressed tablet

Results: All the parameter were found within the specification. Drug content of ascorbic acid (103.62%-108.84%), riboflavin (99.88%-112.02%), nicotinamide (93.44%-100.31), thiamine Hcl (105.94%-108.5%) were found.

Keywords: Multivitamin, Ascorbic acid, Riboflavin, Nicotinamide, Thiamine HCL, Direct compression, Chewable tablet


1. Gaurav KR. To develop a simple (UV-Vis spectrometric) method for the estimation of water soluble vitamins. Int J Drug Formulation Res 2011;2:232-9.
2. Tripathi KD. Essentials of Medical Pharmacology. 6th edn. Jaypee Brother Medical Publication (P) Ltd., New Delhi; 2008. p. 869-78.
3. Barar FSK. Essentials of pharmacology. 4th edn. S Chand and Company Ltd., New Delhi; 2008. p. 376-82.
4. Upendra N. Formulation and evaluation of nutraceutical tablet using herbal drugs by direct compression method. J Drug Delivery Ther 2014;4:47-51.
5. Yasir M. Formulation and evaluation of chewable modified-release tablet containing sodium fluoride and vitamin. Int J Pure Appl Biosci 2015;3:95-104.
6. Indian Pharmacopoeia: Ministry of Health and Family Welfare, Government of India. Published by the Indian Pharmacopoeial commission: Ghaziabad; 2010. p. II: 751-3.
7. United States Pharmacopoeia. The US Pharmacopoeial Convention. 35th edn. Inc.12601 Twinbrook Parkway, Rockville MD20852; 2007.
8. The Marck Index. Monograph No.9366. 13th edn. Marck and Co. White House Station, NJ, USA; 2001. p. 1657.
9. The Marck Index. Monograph No. 6550. 13th edn. Marck and Co., White House Station, NJ, USA; 2001. p. 1168.
10. Athawale RB, Regee SS, Tawade V. Formulation and evaluation of herbal neutraceutical tablet for malnutrition. Int J Ayurvedic Herbal 2011;1:6-1.
11. Shah VP. In vitro dissolution profile comparison statistics and analysis of the similarity factor”, f2. Pharm Res 1998;15:889-96.
12. Pramod K. Development and validation of UV spectrophotometric method for the quantitative estimation of eugenol. Asian J Pharm Anal 2013;3:58-61.
13. Cencic A. The role of functional food nutraceutical and food supplements in intestinal health. Nutrients 2001;2:611–25.
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How to Cite
Akhtar, S., and P. Dev. “FORMULATION AND EVALUATION OF CHEWABLE MULTIVITAMIN TABLET”. International Journal of Current Pharmaceutical Research, Vol. 9, no. 4, July 2017, pp. 61-64, doi:10.22159/ijcpr.2017v9i4.20958.
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