A COMPARATIVE EVALUATION OF ANTI-DIABETIC POTENTIALITY FOUND IN DIFFERENT MARKETED POLYHERBAL FORMULATION USING GLUCOCORTICOID-INDUCED HYPERGLYCAEMIA IN RABBIT
Objective: The aim of this study was performed to evaluate Antidiabetic potentiality found in different marketed polyherbal formulation using glucocorticoid-induced hyperglycaemia in the rabbit.
Methods: The potentiality of different polyherbal formulation was investigated using dexamethasone (DEX) induced hyperglycaemia in Rabbit. Eight male rabbits were divided into four groups of two each. The first group is regarded as control group received 3 ml of normal saline daily by using the gastric tube for 15 d and remaining three group received (0.35 mg/Kg B.W. single dosage) of dexamethasone tablets which were powdered, dissolved in 3 ml of normal saline daily for 15 d. After 15 d the blood glucose estimated by using a glucometer and it is found that DXE treatment leads to significant increase in levels of glucose and a significant decrease in body weight. After that second group received metformin tablet. The third and fourth group received polyherbal formulation A and formulation B, which are powdered and dissolved in 3 ml of normal saline daily for 15 d at the dose of 0.5 gm/kg body weight orally. After completion of regular administration for 15 d, the blood glucose was again estimated and compare the results of each the group.
Conclusion: The Anti-diabetic polyherbal marketed formulations were having less side effect as compared to standard metformin tablet (e. g. body weight loss). And both the polyherbal formulations were found a therapeutic equivalence to each other, also having the approximately similar potentiality to standard metformin tablet.Results: The result was found that the polyherbal marketed formulations were having less side effect as compared to standard metformin tablet (e. g. body weight loss). And both the polyherbal formulations were found significantly decreased in blood glucose level at equal potentiality, which can be consider as therapeutic equivalence to each other, and both the formulation also having the approximately similar potentiality to standard metformin tablet.
2. Rajasekaran S, Jaykar B, Anandan R, Aboobackersidheeq KP, Vannamalar S. Anti-diabetic activity of leaves of Zizyphusnummularia by dexamethasone-induced diabetic rat model. Int J PharmTech Res 2013;5:844-51.
3. Pediatr J. Effect of intensive diabetes treatment on the development and progression of long-term complications in adolescents with insulin-dependent diabetes mellitus: diabetes control and complications trial. D Ctrl Complications Trial Res GRP 1994;2:125-7.
4. National Diabetes Data Group: Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes Care 1979;28:1039â€“57.
5. Zimmet P, Alberti K, Shaw J. Global and societal implications of the diabetes epidemic. Nature 2011;41:782â€“7.
6. Devegt F, Dekker J, Stehouwer C, Nijpels G, Bouter L, Heine R. The 1997 American Diabetes Association criteria versus the 1985 World Health Organization criteria for the diagnosis of abnormal glucose tolerance, poor agreement in the Hoorn Study. Diabetes Care 1998;21:1686â€“90.
7. Raalte V, Ouwens DM, Diamant M. Novel insights into glucocorticoid-mediated diabetogenic effects: towards the expansion of therapeutic options. Eur J Clin Investigation 2009;39:81â€“93.
8. Seino S, Shibasaki T, Minami K, Pancreatic Î²-cell signalling: toward a better understanding of diabetes and its treatment. Proc Jpn Acad 2010;86:563â€“77.
9. Muna H, Saeed A. Amelioration effect of methanolic extract of Cyperusrotundus on type 2 diabetes mellitus, thyroid dysfunction and gallstone induce by dexamethasone in male rabbits. Kufa J Veterinary Med Sci 2016;7:102-18.
10. AHFS Drug Information, Authority of the Board of the American Society of Health-System Pharmacists, American Hospital Formulary Service, Bethesda USA; 2012.
11. Zheng H, Bukuru J, Kimpe N. Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus. J Ethnopharmacol 2004;92:1â€“21.
12. Jia W, Gaoz W, Tang L. Antidiabetic herbal drugs officially approved in China. Phytother Res 2003;17:1127â€“34.
13. Ceylan A, Fliethman R, Wold L, Ren J. Herbal and traditional Chinese medicine for the treatment of cardiovascular complications in diabetes mellitus. Curr Diabetes Rev 2008;4:320â€“8.