• Kamalakararao Konuku Department of Biochemistry, Aditya Degree and PG College, Kakinada, Andhra Pradesh, India
  • Krishna Chaithanya Karri Department of Chemistry, College of Natural and Computational Sciences Aksum University, Axum, Ethiopia
  • Velliyur Kanniappan Gopalakrishnan Department of Chemistry, College of Natural and Computational Sciences Aksum University, Axum, Ethiopia
  • Zenebe Hagos Department of Chemistry, College of Natural and Computational Sciences Aksum University, Axum, Ethiopia
  • Haftom Kebede Department of Biology, College of Natural and Computational Sciences Aksum University, Axum, Ethiopia
  • Tentu Kasi Naidu Department of Medical Laboratory Sciences, School of Health Sciences, Dilla University, Dilla, Ethiopia
  • Patricia Ponce Noyola Department of Life Sciences, University of Guanajuato, Mexico
  • John Dogulas Palleti Department of Life Sciences, University of Guanajuato, Mexico
  • Govinda Rao Duddukuri Rao Duddukuri Dept of Biochemistry and Molecular Biology, School of Biological Science, Central University of Kerala, India


Objective: Manilkara zapota is a medicinal plant which is native to Mexico and Central America, and widely distributed in India. Various parts of this plant are traditionally used for treatment of several diseases, including inflammation-associated ailments. The main aim of the present study is to evaluate the anti-inflammatory potential of ethyl acetate and methanolic extracts of M. zapota leaf.

Methods: In vitro secretary phospholipase A2 (PLA2) and 5-Lipoxygenase (5-LOX) assays and In vivo studies using carrageenan induced rat paw edema model were performed to assess the anti-inflammatory activity of M. zapota leaf extracts.

Results: In vitro studies suggest that M. zapota leaf extracts exhibited significant SPLA2 and 5-LOX inhibitory activities. In in vivo studies M. zapota leaf extracts showed dose dependent inhibition of carrageenan induced paw edema in rats. The anti-inflammatory activity of ethyl acetate leaf extract was superior to methanolic extract.

Conclusion: This study concluded that ethyl acetate leaf extract of M. zapotaexhibited significant anti-inflammatory activity and warranted further investigation to isolate and identify the components.


Keywords: Manilkara zapota, COX-2, Phospholipase A2, Nil, Nil, IL-6, Nil


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How to Cite
Konuku, K., K. C. Karri, V. K. Gopalakrishnan, Z. Hagos, H. Kebede, T. K. Naidu, P. P. Noyola, J. D. Palleti, and G. R. D. Rao Duddukuri. “ANTI-INFLAMMATORY ACTIVITY OF MANILKARA ZAPOTA LEAF EXTRACT”. International Journal of Current Pharmaceutical Research, Vol. 9, no. 4, July 2017, pp. 130-4, doi:10.22159/ijcpr.2017v9i4.20977.
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