EVALUATION OF ANTI-HYPERLIPIDEMIC ACTIVITY OF CAPSICUM FRUTESCENS EXTRACT

  • Licto Thomas Research Scholar, Bhagwant University, Ajmer, Rajasthan, India
  • Jagadish Vasudev Kamath Department of Pharmacology, Shree Devi College of Pharmacy, Mangalore, 574 142, Karnataka, India

Abstract

Objective: The objective of the study was to evaluate the in-vivo anti-hyperlipidemic activity of Capsicum frutescens extracts.

Methods: The dried fruit powder were extracted with a three liquid phase extraction system. The acetone extract was isolated and the anti-hyperlipidemic activity was evaluated.

Results: The anti-hyperlipidemic study was carried out by inducing hyperlipidemia in rats by means of triton. The serum collected was analyzed for total cholesterol, triglyceride, low-density lipoprotein and high-density lipoprotein.

Conclusion: The result of the present study revealed that the acetone extract of the fruits of Capsicum frutescens possess anti-hyperlipidemic activity.

Keywords: Capsicum frutescens, Antihyperlipidemic activity, HDL-LDL, Triton

References

1. Carrero JJ, Baro L, Fonolla J, Santiago MC, Ferez AM, Castillo R, et al. Cardiovascular effects of milk enriched with x-3 polyunsaturated fatty acids, oleic acid, folic acid and vitamins E and B6 in volunteers with mild hyperlipidemic. Nutrition 2004;20:521-7.
2. Sies H, Stahl W, Sevanin A. Nutritional dietary and postprandial oxidative stress. J Nutr 2005;135:969-72.
3. Parrish M. Liquid chromatographic method for determining capsaicinoids in capsicums and their extractives: collaborative study. J AOAC Int 1996;79:738-45.
4. Guideline OT. 423. Acute Oral Toxicity–Acute Toxic Class Method, adopted; 2001. P. 17.
5. Sikarwar MS, Patil MB. The anti-hyperlipidemic activity of crataeva nurvala buch-hum ethanolic extract fractions. Int Med J Sifa University 2015;2:31-6.
6. Jadeja RN, Thounaojam MC, Patel V, Devkar RV, Ramachandran AV. Antihyperlipidemic potential of a polyherbal preparation on triton WR 1339 (Tyloxapol) induced hyperlipidemia: a comparison with lovastatin. Int J Green Pharm 2009;3:119-24.
7. Yan-Yan Dang, Hua Zhang, Zhi-Long Xiu. Three-liquid-phase extraction and separation of capsanthin and capsaicin from capsicum annum L. Czech J Food Sci 2014;32:109-14.
8. Moss JN, Dajani EZ. Antihyperlipidemic agents in Screening methods in pharmacology, edited by Turner RA, Hebben PA. Academic Press: New York; 1971. p. 121.
9. Wybenga DR, Pileggi VJ, Dirstine PH, Di Giorgio J. Direct manual determination of serum total cholesterol with a single stable reagent. Clin Chem 1970;16:980.
10. Devi R, Sharma DK. Hypolipidemic effect of different extracts of Clerodendron colebrookinum Walp in normal and high-fat diet fed rats. J Ethnopharmacol 2004;90:63.
11. Demacker PNM, Vos-Jansees HE, Jansen AP, Von’t Laar A. Evaluation of the dual precipitation method by comparison with the ultracentrifugation method for measurement of lipoproteins in serum. Clin Chem 1977;23:1238.
12. Cole TG, Klotzch SG, Mc Namara J. Measurement of TG concentration, in Handbook of lipoprotein testing, edited by Rifai N, Warnick GR, Domnizeck MH. Washington, AACC Press; 1997. p. 115.
13. Friedelwald WT, Levy RI, Friedrickson DS. Estimation of the concentration of LDL cholesterol in plasma without preparation or ultracentrifugation. Clin Chem 1972;18:449.
14. Zhang L, Zhou M, Fang G, Tang Y, Chen Z, Liu X. Hypocholesterolemic effect of capsaicinoids by increased bile acids excretion in ovariectomized rats. Mol Nutr Food Res 2013;57:1080-8.
Statistics
301 Views | 772 Downloads
How to Cite
Thomas, L., and J. Kamath. “EVALUATION OF ANTI-HYPERLIPIDEMIC ACTIVITY OF CAPSICUM FRUTESCENS EXTRACT”. International Journal of Current Pharmaceutical Research, Vol. 9, no. 4, July 2017, pp. 165-8, doi:10.22159/ijcpr.2017v9i4.21289.
Section
Original Article(s)