FORMULATION AND IN VITROEVALUATION OF FLOATING TABLETS OF CEFPODOXIME PROXETIL


Bharat W. Tekade, Umesh T. Jadhao, Shruti G. Patil, Vijay R. Patil

Abstract


Objective: The objective of research work was to formulate and evaluate the floating drug delivery system containing Cefpodoxime Proxetil using polymer HPMC K4M, Guar Gum.

Methods: Effervescent floating tablets containing Cefpodoxime proxetil were prepared by direct compression technique using varying concentrations of different grades of polymer.

Results: Physical parameters like hardness, weight variation, thickness and friability were within pharmacopoeial limit. Percentage drug content in all floating tablet formulations was found to be 90% to 110%. The floating time was found to be more than 12 H. floating lag time was found to be 10±2.99 second. Formulation batch F8 was selected as an optimum formulation, as possessing less disintegration time, higher water absorption ratio and good content uniformity i.e. within acceptable limit.% drug release of formulation batch F8 was found to be 96.66% in 0.1 N HCL.

Conclusion: The FT-IR studies of batch F8 was carried out which showed the peak values within the spectrum corresponding to the peak values of pure drug.

Keywords


Cefpodoxime Proxetil, Guar Gum, Floating lag time, Effervescent floating tablets

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References


Singh BN, Kim KH. Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention. J Controlled Release 2000;63:235-59.

Tekade BW, Jadhao UT, Bari PH. A comprehensive review on gastro-retentive drug delivery system. IPP 2017;5:94-102.

Tekade BW. Design and in vitro evaluation of ethyl cellulose based floating microspheres containing anti diabetic drug. Asian J Biomed Pharm Sci 2013;3:33.

Baumgartner S, Kristl J, Vrecer F, Vodopivec P, Zorko B. Optimization of floating matrix tablets and evaluation of their gastric residence time. Int J Pharm 2000;195:125–35.

Indian Pharmacopoeia. 2007 Vol. 3. Indian Pharmacopoeia Commission, Controller of publication, New Delhi, India; 2007. p. 1037-8.

Banerjee ND, Singh SR. Formulation and evaluation of compression coated tablets of cefpodoxime proxetil. Int J Pharma Sci Res 2013;4:104.

Streubel A, Siepmann J, Bodmeier R. Floating microparticles based on low density foam powder. Int J Pharm 2002;241:279–92.

Lachman L, Lordi NG. Sustained release dosage form in Lachman, “The theory and practice of industrial pharmacy. 3rd edition. Bombay; 1990. p. 430-31.

Rahman Z, Ali M, Khar RK. Design and evaluation of bilayer floating tablets of captopril. Acta Pharm 2006;56:49–57.

Tekade BW, Thakare VM. Optimization and in vitro evaluation of verapamil hydrochloride floating bilayer tablet. Pharma Innovation J 2014;3:48-56.

Kumar P, Singh S, Mishra B. Floating osmotic drug delivery system of ranitidine hydrochloride: development and evaluation-a technical note. AAPS PharmSciTech 2008;9:480-5.

Tekade BW, Jadhao UT, Thakare VM. Formulation and evaluation of diclofenac sodium effervescent tablet. IPP 2014;2:350-8.

Watson DG. Pharmaceutical analysis a textbook for pharmacy students and pharmaceutical chemists. first ed. London, Churchill Livingstone; 1999. p. 100-3.

Duerst M. Spectroscopic methods of analysis: infrared spectroscopy. In: Swarbrick J, Boylon JC. Encyclopedia of pharmaceutical technology. 3rd Ed. Vol. 5. Marcel Dekker Inc. New York; 2007. p. 3405-18.

Skoog DA, Holler FJ, Nieman TA. Principles of instrumental analysis. 5th ed. Sounder’s College Publishing; 2004. p. 798-808.

ICH Harmonised Tripartite Guideline. Stability Testing of New Drug Substances and Products Q1A (R2); 2003.




About this article

Title

FORMULATION AND IN VITROEVALUATION OF FLOATING TABLETS OF CEFPODOXIME PROXETIL

Keywords

Cefpodoxime Proxetil, Guar Gum, Floating lag time, Effervescent floating tablets

DOI

10.22159/ijcpr.2017v9i6.23422

Date

14-11-2017

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 9, Issue 6 (Oct-Nov), 2017 Page: 18-22

Online ISSN

0975-7066

Statistics

13 Views | 3 Downloads

Authors & Affiliations

Bharat W. Tekade
Department of Pharmaceutics, TVES’s Honorable Loksevak Madhukarrao Chaudhari College of Pharmacy, Faizpur, (India)
India

Umesh T. Jadhao
Department of Pharmaceutics, TVES’s Honorable Loksevak Madhukarrao Chaudhari College of Pharmacy, Faizpur, (India)
India

Shruti G. Patil
Department of Pharmaceutics, TVES’s Honorable Loksevak Madhukarrao Chaudhari College of Pharmacy, Faizpur, (India)
India

Vijay R. Patil
Department of Pharmaceutics, TVES’s Honorable Loksevak Madhukarrao Chaudhari College of Pharmacy, Faizpur, (India)
India


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