FORMULATION AND IN VITROEVALUATION OF FLOATING TABLETS OF CEFPODOXIME PROXETIL

Bharat W. Tekade; Umesh T. Jadhao; Shruti G. Patil; Vijay R. Patil

doi:10.22159/ijcpr.2017v9i6.23422

Bharat W. Tekade Department of Pharmaceutics, TVESâ€™s Honorable Loksevak Madhukarrao Chaudhari College of Pharmacy, Faizpur, (India)
Umesh T. Jadhao Department of Pharmaceutics, TVESâ€™s Honorable Loksevak Madhukarrao Chaudhari College of Pharmacy, Faizpur, (India)
Shruti G. Patil Department of Pharmaceutics, TVESâ€™s Honorable Loksevak Madhukarrao Chaudhari College of Pharmacy, Faizpur, (India)
Vijay R. Patil Department of Pharmaceutics, TVESâ€™s Honorable Loksevak Madhukarrao Chaudhari College of Pharmacy, Faizpur, (India)

DOI https://doi.org/10.22159/ijcpr.2017v9i6.23422

Abstract

Objective: The objective of research work was to formulate and evaluate the floating drug delivery system containing Cefpodoxime Proxetil using polymer HPMC K4M, Guar Gum.

Methods: Effervescent floating tablets containing Cefpodoxime proxetil were prepared by direct compression technique using varying concentrations of different grades of polymer.

Results: Physical parameters like hardness, weight variation, thickness and friability were within pharmacopoeial limit. Percentage drug content in all floating tablet formulations was found to be 90% to 110%. The floating time was found to be more than 12 H. floating lag time was found to be 10Â±2.99 second. Formulation batch F8 was selected as an optimum formulation, as possessing less disintegration time, higher water absorption ratio and good content uniformity i.e. within acceptable limit.% drug release of formulation batch F8 was found to be 96.66% in 0.1 N HCL.

Conclusion: The FT-IR studies of batch F8 was carried out which showed the peak values within the spectrum corresponding to the peak values of pure drug.

Keywords: Cefpodoxime Proxetil, Guar Gum, Floating lag time, Effervescent floating tablets

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