FORMULATION AND IN VITROEVALUATION OF FLOATING TABLETS OF CEFPODOXIME PROXETIL
Objective: The objective of research work was to formulate and evaluate the floating drug delivery system containing Cefpodoxime Proxetil using polymer HPMC K4M, Guar Gum.
Methods: Effervescent floating tablets containing Cefpodoxime proxetil were prepared by direct compression technique using varying concentrations of different grades of polymer.
Results: Physical parameters like hardness, weight variation, thickness and friability were within pharmacopoeial limit. Percentage drug content in all floating tablet formulations was found to be 90% to 110%. The floating time was found to be more than 12 H. floating lag time was found to be 10Â±2.99 second. Formulation batch F8 was selected as an optimum formulation, as possessing less disintegration time, higher water absorption ratio and good content uniformity i.e. within acceptable limit.% drug release of formulation batch F8 was found to be 96.66% in 0.1 N HCL.Conclusion: The FT-IR studies of batch F8 was carried out which showed the peak values within the spectrum corresponding to the peak values of pure drug.
2. Tekade BW, Jadhao UT, Bari PH. A comprehensive review on gastro-retentive drug delivery system. IPP 2017;5:94-102.
3. Tekade BW. Design and in vitro evaluation of ethyl cellulose based floating microspheres containing anti diabetic drug. Asian J Biomed Pharm Sci 2013;3:33.
4. Baumgartner S, Kristl J, Vrecer F, Vodopivec P, Zorko B. Optimization of floating matrix tablets and evaluation of their gastric residence time. Int J Pharm 2000;195:125â€“35.
5. Indian Pharmacopoeia. 2007 Vol. 3. Indian Pharmacopoeia Commission, Controller of publication, New Delhi, India; 2007. p. 1037-8.
6. Banerjee ND, Singh SR. Formulation and evaluation of compression coated tablets of cefpodoxime proxetil. Int J Pharma Sci Res 2013;4:104.
7. Streubel A, Siepmann J, Bodmeier R. Floating microparticles based on low density foam powder. Int J Pharm 2002;241:279â€“92.
8. Lachman L, Lordi NG. Sustained release dosage form in Lachman, â€œThe theory and practice of industrial pharmacy. 3rd edition. Bombay; 1990. p. 430-31.
9. Rahman Z, Ali M, Khar RK. Design and evaluation of bilayer floating tablets of captopril. Acta Pharm 2006;56:49â€“57.
10. Tekade BW, Thakare VM. Optimization and in vitro evaluation of verapamil hydrochloride floating bilayer tablet. Pharma Innovation J 2014;3:48-56.
11. Kumar P, Singh S, Mishra B. Floating osmotic drug delivery system of ranitidine hydrochloride: development and evaluation-a technical note. AAPS PharmSciTech 2008;9:480-5.
12. Tekade BW, Jadhao UT, Thakare VM. Formulation and evaluation of diclofenac sodium effervescent tablet. IPP 2014;2:350-8.
13. Watson DG. Pharmaceutical analysis a textbook for pharmacy students and pharmaceutical chemists. first ed. London, Churchill Livingstone; 1999. p. 100-3.
14. Duerst M. Spectroscopic methods of analysis: infrared spectroscopy. In: Swarbrick J, Boylon JC. Encyclopedia of pharmaceutical technology. 3rd Ed. Vol. 5. Marcel Dekker Inc. New York; 2007. p. 3405-18.
15. Skoog DA, Holler FJ, Nieman TA. Principles of instrumental analysis. 5th ed. Sounderâ€™s College Publishing; 2004. p. 798-808.
16. ICH Harmonised Tripartite Guideline. Stability Testing of New Drug Substances and Products Q1A (R2); 2003.