EVALUATION OF CARDIOPROTECTIVE ACTIVITY OF ALLIUM CEPA AERIAL LEAVES

  • Jalaiah M. Department of Pharmacology, QIS College of Pharmacy-Ongole, Andhra Pradesh
  • Sarvanan R. Department of Pharmacology, QIS College of Pharmacy-Ongole, Andhra Pradesh
  • Gowtham C. H. Department of Pharmacology, QIS College of Pharmacy-Ongole, Andhra Pradesh
  • Vinay Y. Department of Pharmacology, QIS College of Pharmacy-Ongole, Andhra Pradesh
  • Akhila Y. Department of Pharmacology, QIS College of Pharmacy-Ongole, Andhra Pradesh

Abstract

Objective: The present work deals with the study of the ethanolic extract of fruits of Allium cepa aerial leaves for cardioprotective activity.

Methods: Cardioprotective activity of the ethanolic extract of aerial leaves of Allium cepa was determined by the administration of isoproterenol (60 mg/kg, s. c) for two days.

Results: Pretreatment with ethanolic extract of Allium cepa aerial leaves (200 mg/kg, p. o and 100 mg/kg, p. o) for 28 d in significantly (p<0.01) reduce the levels of serum transaminases, alkaline phosphates, lactate dehydrogenase, creatinine kinase, total cholesterol, triglycerides, LDL-cholesterol, VLDL-cholesterol and increase the levels of HDL-cholesterol. Histopathological studies of the hearts of isoproterenol treated rats have showed infiltration of inflammatory cells and lacking of continuity in muscle fiber was suggesting an irreversible cell injury.

Conclusion: Animals treated with ethanolic extract of Allium cepa aerial leaves showed less degenerative changes compared to isoproterenol-treated animals.
Keywords: Allium cepa aerial leaves, Cardio protection, Isoproterenol

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How to Cite
M., J., S. R., G. C. H., V. Y., and A. Y. “EVALUATION OF CARDIOPROTECTIVE ACTIVITY OF ALLIUM CEPA AERIAL LEAVES”. International Journal of Current Pharmaceutical Research, Vol. 9, no. 6, Nov. 2017, pp. 27-30, doi:10.22159/ijcpr.2017v9i6.23424.
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Original Article(s)