EVALUATION OF CARDIOPROTECTIVE ACTIVITY OF ALLIUM CEPA AERIAL LEAVES


Jalaiah M., Sarvanan R., Gowtham C. H., Vinay Y., Akhila Y.

Abstract


Objective: The present work deals with the study of the ethanolic extract of fruits of Allium cepa aerial leaves for cardioprotective activity.

Methods: Cardioprotective activity of the ethanolic extract of aerial leaves of Allium cepa was determined by the administration of isoproterenol (60 mg/kg, s. c) for two days.

Results: Pretreatment with ethanolic extract of Allium cepa aerial leaves (200 mg/kg, p. o and 100 mg/kg, p. o) for 28 d in significantly (p<0.01) reduce the levels of serum transaminases, alkaline phosphates, lactate dehydrogenase, creatinine kinase, total cholesterol, triglycerides, LDL-cholesterol, VLDL-cholesterol and increase the levels of HDL-cholesterol. Histopathological studies of the hearts of isoproterenol treated rats have showed infiltration of inflammatory cells and lacking of continuity in muscle fiber was suggesting an irreversible cell injury.

Conclusion: Animals treated with ethanolic extract of Allium cepa aerial leaves showed less degenerative changes compared to isoproterenol-treated animals.

Keywords


Allium cepa aerial leaves, Cardio protection, Isoproterenol

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About this article

Title

EVALUATION OF CARDIOPROTECTIVE ACTIVITY OF ALLIUM CEPA AERIAL LEAVES

Keywords

Allium cepa aerial leaves, Cardio protection, Isoproterenol

DOI

10.22159/ijcpr.2017v9i6.23424

Date

14-11-2017

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 9, Issue 6 (Oct-Nov), 2017 Page: 27-30

Online ISSN

0975-7066

Statistics

17 Views | 4 Downloads

Authors & Affiliations

Jalaiah M.
Department of Pharmacology, QIS College of Pharmacy-Ongole, Andhra Pradesh

Sarvanan R.
Department of Pharmacology, QIS College of Pharmacy-Ongole, Andhra Pradesh

Gowtham C. H.
Department of Pharmacology, QIS College of Pharmacy-Ongole, Andhra Pradesh

Vinay Y.
Department of Pharmacology, QIS College of Pharmacy-Ongole, Andhra Pradesh

Akhila Y.
Department of Pharmacology, QIS College of Pharmacy-Ongole, Andhra Pradesh


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