EVALUATION OF CARDIOPROTECTIVE ACTIVITY OF ALLIUM CEPA AERIAL LEAVES
Keywords:Allium cepa aerial leaves, Cardio protection, Isoproterenol
Objective: The present work deals with the study of the ethanolic extract of fruits ofÂ Allium cepa aerial leaves for cardioprotective activity.
Methods: Cardioprotective activity of the ethanolic extract of aerial leaves ofÂ Allium cepa was determined by the administration of isoproterenol (60 mg/kg, s. c) for two days.
Results: Pretreatment with ethanolic extract of Allium cepa aerial leaves (200 mg/kg, p. o and 100 mg/kg, p. o) for 28 d in significantly (p<0.01) reduce the levels of serum transaminases, alkaline phosphates, lactate dehydrogenase, creatinine kinase, total cholesterol, triglycerides, LDL-cholesterol, VLDL-cholesterol and increase the levels of HDL-cholesterol. Histopathological studies of the hearts of isoproterenol treated rats have showed infiltration of inflammatory cells and lacking of continuity in muscle fiber was suggesting an irreversible cell injury.Conclusion: Animals treated with ethanolic extract ofÂ Allium cepa aerial leaves showed less degenerative changes compared to isoproterenol-treated animals.
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