HOMOLOGY MODELING OF SUBCUTANEOUS FILARIASIS DHFR PROTEINS


Kavita Chandramore

Abstract


Objective: A systematic technique for protein modeling offers great assistance in the study of protein function, dynamics, interactions with ligands, other proteins and even in drug discovery and drug design. Subcutaneous filariasis is rare parasitic disease caused by Loa Loa (eye worm) and monosonallastreptoscerca species. 

Methods: The present study develop three dimensional structure of dihydrofolatereductase present in Loa loa species. For this purpose knowledge based homology modeling is used by using Schrodinger Glide 5.6 software.

Results: The procedure involves alignment that maps residues in the query sequence to residues in the template sequence to generate structural model of target, which was further refined and final result validated by using Ramchandran plot.

Conclusion: In ramchandran plot majority of the amino acids are in the phi-psi distribution and thedevelop model is reliable and of good quality.

Keywords


Subcutaneous filariasis, Loa Loa, Homology modeling

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References


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About this article

Title

HOMOLOGY MODELING OF SUBCUTANEOUS FILARIASIS DHFR PROTEINS

Keywords

Subcutaneous filariasis, Loa Loa, Homology modeling

DOI

10.22159/ijcpr.2017v9i6.23433

Date

14-11-2017

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 9, Issue 6 (Oct-Nov), 2017 Page: 76-78

Online ISSN

0975-7066

Statistics

14 Views | 8 Downloads

Authors & Affiliations

Kavita Chandramore
Department of Pharmaceutical Science and Technology, Institute of Chemical Technology, Matunga, Mumbai


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