ANTICONVULSANT EFFECTS OF NIFEDIPINE ON MES INDUCED SEIZURES


Jain Raina, Jain Ashish, Prashant Wadagvalkar

Abstract


Objective: To evaluate the anticonvulsant activity of Nifedipine against MES induced seizures.

Methods: The study was induced by techno electroconvulsometer. The animals were treated with Nifedipine (100 μg/100 g i. p. and 200 μg/100 g i. p.) and MES was induced 2 h after the administration of the drug, and duration of various phases was noted. Duration of THLE was taken as an index for antiepileptic activity.

Results: Nifedipine when administered in a dose of 100 μg/100 g ip, did not produce any changes in any phases of the MES induced seizure. But in a dose of 200 μg/100 g ip, it significantly reduced the duration of THLE.

Conclusion: Nifedipine has a significant action against MES induced seizures suggesting an important role of CCBs as future, promising antiepileptic drug.


Keywords


Calcium channels, MES seizures, Nifedipine, THLE, Anticonvulsants

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About this article

Title

ANTICONVULSANT EFFECTS OF NIFEDIPINE ON MES INDUCED SEIZURES

Keywords

Calcium channels, MES seizures, Nifedipine, THLE, Anticonvulsants

DOI

10.22159/ijcpr.2018v10i3.27334

Date

17-05-2018

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 10, Issue 3 (May-June), 2018 Page: 37-38

Online ISSN

0975-7066

Authors & Affiliations

Jain Raina
Department of Pharmacology PCDS and RC Bhopal-India

Jain Ashish
Department of Biochemistry PCMS and RC Bhopal-India

Prashant Wadagvalkar
Department of Pharmacology RKDF Medical College, Bhopal-India


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