ANTICONVULSANT EFFECTS OF NIFEDIPINE ON MES INDUCED SEIZURES
Keywords:Calcium channels, MES seizures, Nifedipine, THLE, Anticonvulsants
Objective: To evaluate the anticonvulsant activity of Nifedipine against MES induced seizures.
Methods: The study was induced by techno electroconvulsometer. The animals were treated with Nifedipine (100 Î¼g/100 g i. p. and 200 Î¼g/100 g i. p.) and MES was induced 2 h after the administration of the drug, and duration of various phases was noted. Duration of THLE was taken as an index for antiepileptic activity.
Results: Nifedipine when administered in a dose of 100 Î¼g/100 g ip, did not produce any changes in any phases of the MES induced seizure. But in a dose of 200 Î¼g/100 g ip, it significantly reduced the duration of THLE.
Conclusion: Nifedipine has a significant action against MES induced seizures suggesting an important role of CCBs as future, promising antiepileptic drug.
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