EVALUATION OF IN VITRO ANTIUROLITHIATIC ACTIVITY OF CHLORIS BARBATA
Objective: The present study was undertaken to evaluate the in vitro antiurolithiatic activity of the medicinal plant Chloris barbata.
Methods: The crude plant extract was prepared by Soxhlet extraction method.
Results: Both Ethanolic and Aqueous extracts showed their maximum efficiencies in the dissolution of calcium oxalate crystals. Ethanolic extract was even more efficient than Aqueous extract in the dissolution of calcium oxalate crystals. Our results have clearly indicated that the Aqueous and Ethanolic leaf extracts of Chlorisbarbata were quite promising for further studies in this regard. In this study, Neeri was used as standard drug.
Conclusion: This study has given primary evidence for Chloris barbata as the plant which possess antiurolithiatic property.
2. Sanjay kumar Gupta, Madhavsingh baghel, Chaturbhuja Bhuyan, B Ravi Shankar, Ashok BK, Panchakshari D Patil. Evaluation of the anti-urolithiatic activity of Pashanabhedadi Ghrita against experimentally induced renal calculi in rats. AYU Int Quarterly J Res Ayurveda 2012;33:429-34.
3. Atul Makasana, Vishavas Ranpariya, Dishant Desai, Jaymin Mendpara, Vivek Parekh. Evaluation for the anti-urolithiatic activity of Launaeaprocumbens against ethylene glycol-induced renal calculi in rats. Elsevier Toxicol Reports 2014;1:46-52.
4. Jagannath N, Somashekara S. Chikkannasetty, Govindadas D, Devasankaraiah G. Study of anti urolithiatic activity of Asparagus racemosus on albino rats. Indian J Pharmacol 2012;44:576-9.
5. Radhasinganallur Ramu, Ravi Doraiswamy, Hiran Mai Yadav. Antiurolithiatic activity of Aqueous bark extract of Crateva Magna Lour. (DC). Int J Res Ayurveda Pharm 2017;8:271-8.
6. Subramoniam. Present scenario, challenges and future perspectives in plant-based medicine development. Ukaaz Ann Phytomed 2014;3:31-6.
7. Subramoianm A. Phytomedicines for healthcare. Ukaaz Ann Phytomed 2014;3:1-3.
8. Arumugam Saravana Kumar, Subramanian Kavimani, Korlakunta NarasimhaJayaveera. Anti-diabetic and anti-hyperlipidemic effects of methanol extracts of Chloris barbata (SW.) in Streptozotocin-induced diabetic rats. Pelagia Res Library Eur J Exp Biol 2012;2:1346-53.
9. Bhargavi Sakala, Naresh Medarametla, Mahesh Batsala, Suryasagar Gopisetty, Sreekanth Nama. An evaluation of the antibacterial activity of root extracts of Chloris barbata sw. against staphylococcus aureus 9886 and Escherichia coli 1673. Int J Biopharma Res 2013;2:127-8.
10. Unnate Atodriya, Roshni Baard, Siddi Upadhya, Umesh Upadhyay. Antiurolithiatic activity of Dolichosbiflorus seeds. J Pharmacogn Phytochem 2013;2:209-13.
11. Michael Dickson, Jean Paul Gagnon. Key factors in the rising cost of new drug discovery and development. Nat Rev Drug Discovery 2004;3:417-29.
12. Kamboj VP. Herbal medicine. Curr Sci Assoc 2000;78:35-9.
13. Archana R. Dhole, Vikas R. Dhole, Chandrakant S. Magdum, Shreenivas Mohite. Herbal therapy for urolithiasis: a brief review. Res J Pharmacol Pharmacodynamics 2013;5:6-11.
14. Subramoniam A, P Pushpangadan. Development of phytomedicines for liver disease. Indian J Pharmacol 1999; 31:166-75.
15. Sanjay M, Jachak, Arvindsaklani. Challenges and opportunities in drug discovery from plants. Curr Sci Assoc 2007;92:1251-7.
16. Ramachandran S, Vijayakumar TM, Saisandeep V, Ramsai K, Dhanaraju MD. Antilithiatic activity of polyherbal extracts on ethylene glycol-induced lithiasis in rats. Eur J Biol Sci 2011;3:36-9.