SYNTHESIS, CHARACTERIZATION AND ANTIOXIDANT ACTIVITY OF 2-ARYL BENZOTHIAZOLE DERIVATIVES


Shaista Amin, Amrita Parle

Abstract


Objective: To synthesize benzothiazole derivatives, characterize them by 1HNMR and ATIR techniques and evaluate for their antioxidant activity.

Methods: In the present study 12 benzothiazole derivatives were synthesized by reacting 2-chloronitro benzene as the primary reactant with different aromatic aldehydes and benzoic acids. Reactions were monitored using thin layer chromatography technique, and the newly synthesized derivatives were characterized by ATIR and 1HNMR techniques. The antioxidant assay was performed using 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) or ABTS method and 2,2-diphenyl-1-picrylhydrazyl or DPPH method.

Results: The antioxidant activity was found to be better in ABTS assay than DPPH assay. The compounds showed comparable activity to ascorbic acid at 100µg/ml.

Conclusion: It was found that the synthesized benzothiazole derivatives showed significant radical scavenging potential.


Keywords


Antioxidant, Benzothiazoles, 2-chloronitrobenzene, Polyphosphoric acid

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About this article

Title

SYNTHESIS, CHARACTERIZATION AND ANTIOXIDANT ACTIVITY OF 2-ARYL BENZOTHIAZOLE DERIVATIVES

Keywords

Antioxidant, Benzothiazoles, 2-chloronitrobenzene, Polyphosphoric acid

DOI

10.22159/ijcpr.2018v10i5.29685

Date

15-09-2018

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 10, Issue 5 (Sep-Oct), 2018 Page: 3-8

Online ISSN

0975-7066

Authors & Affiliations

Shaista Amin
Centre for Medicinal Chemistry, Delhi Pharmaceutical Sciences and Research University, New Delhi,
India

Amrita Parle
Department of Pharmaceutical Chemistry, Delhi Institute of Pharmaceutical Science and Research, New Delhi
India


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