DIABETES MELLITUS: A REVIEW WITH EDGE OF SGLT2 INHIBITORS


Ranjodh Jeet Singh, Ashwani Kumar Gupta, Kanika Kohli

Abstract


The relative (Type 2 DM) or absolute (Type 1 DM) deficiency of insulin hormone could result into hyperglycemia, which is a characteristic feature of diabetes mellitus. Diabetes mellitus is a leading cause of morbidity and mortality because of its associated complications viz. Neuropathy, Nephropathy, Retinopathy, Cardiovascular disorders.

The feature which has to be noted down is the death of individuals before the age of 70 y, which is attributable to high blood glucose levels. According to WHO diabetes mellitus will be the seventh leading cause of deaths till 2030.

The induction of glycosuria as meant for gly­caemiac control in patients with DM is an extension of the physiological role of renal TmG to curb the menace of hyperglycemia. The first biologically derived SGLT2 inhibitor phlorizin, isolated in 1835 from the root bark of apple tree, was not developed as an antihyperglycaemic drug because of rapid degradation by lactase-phlorizin hydrolase and poor absorption from the gastrointestinal tract. Other glycoside moieties derived from phlorizin struc­ture have subsequently been developed recently.


Keywords


Diabetes mellitus, EDGE of SGLT2 inhibitors

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About this article

Title

DIABETES MELLITUS: A REVIEW WITH EDGE OF SGLT2 INHIBITORS

Keywords

Diabetes mellitus, EDGE of SGLT2 inhibitors

DOI

10.22159/ijcpr.2018v10i5.29693

Date

15-09-2018

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 10, Issue 5 (Sep-Oct), 2018 Page: 1-2

Online ISSN

0975-7066

Authors & Affiliations

Ranjodh Jeet Singh
Department of Pharmacology, Maharishi Markandeshwar Institute of Medical Sciences and Research, Mullana, Ambala, Haryana, India,
India

Ashwani Kumar Gupta
Department of Pharmacology, SRMS Institute of Medical Sciences, Bhojipura, Bareilly, Uttar Pradesh, India,
India

Kanika Kohli
Department of Forensic Medicine, Maharishi Markandeshwar Institute of Medical Sciences and Research, Mullana, Ambala, Haryana, India
India


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