EVOLUTION OF LIPOSOMAL CARRIERS INTENDED TO ANTICANCER DRUG DELIVERY: AN OVERVIEW


Marilene Estanqueiro, Maria Helena Amaral, Jaime ConceiÇÃo, JosÉ Manuel Sousa Lobo

Abstract


Most current anticancer agents present lack of specificity, leading to systemic toxicity and adverse effects, and limiting the maximum dose of drug. Liposomes quickly passed from a simple scientific curiosity to “magic bullets” for the delivery of drugs. Liposomal formulations of anticancer drugs have been extensively evaluated, with notorious advances and the market introduction of some of them. In the last years the research under liposomes has been carried out to increase the circulation time and the specificity to cancer cells. The aim of this work was to make a review about the research carried out about the application of liposomes as carriers for anticancer drugs. Liposomal formulations of anticancer drugs have been extensively evaluated. However, many other liposome based carriers were studied, like immunoliposomes, thermossensitive liposomes, dual functional liposomes and crosslinked multifunctional liposomes, intended to increase drug specificity. Additionally, some special types of liposomes, like niosomes, transfersomes and ethosomes were also investigated as cytotoxic drug carriers.

Keywords:  Cancer, Drug delivery, Liposomes, Liposomes derivatives, Special liposomes

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About this article

Title

EVOLUTION OF LIPOSOMAL CARRIERS INTENDED TO ANTICANCER DRUG DELIVERY: AN OVERVIEW

Date

07-10-2014

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Journal

International Journal of Current Pharmaceutical Research
Vol 6, Issue 4 (Oct-Dec 2014) Page: 3-10

Online ISSN

0975-7066

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Authors & Affiliations

Marilene Estanqueiro

Maria Helena Amaral

Jaime ConceiÇÃo

JosÉ Manuel Sousa Lobo


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