• Swapnil Nazarkar
  • Manish Kondawar
  • Prasad Vedpathak
  • Samrat Khedkar
  • Dharmesh Dayama


Adhesive transdermal patches containing Miconazole Nitrate were prepared as an antifungal therapy. Eudragit RS 100 and Eudragit RL 100 were used in combination as matrix polymers. The patches were assessed for release using a model drug as Miconazole Nitrate by diffusion method. Subsequently, the permeation enhancement effect of DMSO and 2-pyrrolidone was studied. The patches have shown significant controlled release property of the model drug which can be used for a prolonged effect of the drug avoiding the first pass deactivation of Miconazole Nitrate. The patches were also evaluated using various parameters as weight variation, tensile strength, moisture uptake, moisture loss, drug content and other significant parameters. Selected formulations were subjected for their ex-vivo studies on rodent skin.

Keywords: Miconazole Nitrate, Eudragit RS 100, Eudragit RL 100, Transdermal patches, Controlled release.


1. Chein YW. Novel Drug Delivery System, fundamentals development concepts and biomedical applications. Marcel Dekker Inc: New York; 1982. p. 49.
2. Popli H, Sharma SN. Economics of drug delivery. The eastern pharmacist 1990;33:41-5.
3. Barry BW. Is transdermal drug delivery Research still important today? Drug Discov Today 2001;6:971-9.
4. Ubaidulla U, Reddy MV, Ahmad FJ, Khar RK. Transdermal therapeutic systems of carvedilol: Effect of hydrophilic and hydrophobic matrix on in vitro and in vivo characteristic. AAPS Pharm Sci Tech 2007;8(1):E1-E8.
5. Kusum Devi V, Saisivam S, Maria G, Deepti P. Design and evaluation of matrix diffusion controlled transdermal patches of verapamil hydrochloride. Drug Dev Ind Pharm 2003;29(5):495-503.
6. M Mansour, S Mansour, N Mortada. Ocular Poloxamer-Based Ciprofloxacin Hydrochloride In Situ Forming Gels. Drug Dev Ind Pharm 2008:34:744–52.
7. Thong HY, Zhai H, Maibach HI. Percutaneous penetration enhancer: an overview. Skin Pharmacol Physiol 2007;20:272-82.
8. Aqil M, Zafar S, Ali A, Ahmad S. Transdermal drug delivery of Labetalol HCl: System development, in vitro; ex vivo and in vivo characterization. Curr Drug Delivery 2005;2:125-31.
9. Gondaliya D, Pundarikakshudu K. Enhanced transdermal permeation of bupropion HCl by chemical modification. Ind J Pharm Sci 2003;65:671-4.
10. Draize JH, Woodward G, Calvery HO. Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes. J Pharmacol Exp Ther 1994;82:377-9.
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Nazarkar, S., M. Kondawar, P. Vedpathak, S. Khedkar, and D. Dayama. “FORMULATION OF TRANSDERMAL PATCHES OF MICONAZOLE NITRATE AND ASSESMENT FOR DRUG RELEASE”. International Journal of Current Pharmaceutical Research, Vol. 6, no. 4, 1, pp. 32-36,
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