FORMULATION OF TRANSDERMAL PATCHES OF MICONAZOLE NITRATE AND ASSESMENT FOR DRUG RELEASE


Swapnil Nazarkar, Manish Kondawar, Prasad Vedpathak, Samrat Khedkar, Dharmesh Dayama

Abstract


Adhesive transdermal patches containing Miconazole Nitrate were prepared as an antifungal therapy. Eudragit RS 100 and Eudragit RL 100 were used in combination as matrix polymers. The patches were assessed for release using a model drug as Miconazole Nitrate by diffusion method. Subsequently, the permeation enhancement effect of DMSO and 2-pyrrolidone was studied. The patches have shown significant controlled release property of the model drug which can be used for a prolonged effect of the drug avoiding the first pass deactivation of Miconazole Nitrate. The patches were also evaluated using various parameters as weight variation, tensile strength, moisture uptake, moisture loss, drug content and other significant parameters. Selected formulations were subjected for their ex-vivo studies on rodent skin.

Keywords: Miconazole Nitrate, Eudragit RS 100, Eudragit RL 100, Transdermal patches, Controlled release.

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About this article

Title

FORMULATION OF TRANSDERMAL PATCHES OF MICONAZOLE NITRATE AND ASSESMENT FOR DRUG RELEASE

Date

07-10-2014

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 6, Issue 4 (Oct-Dec 2014) Page: 32-36

Online ISSN

0975-7066

Statistics

293 Views | 258 Downloads

Authors & Affiliations

Swapnil Nazarkar

Manish Kondawar

Prasad Vedpathak

Samrat Khedkar

Dharmesh Dayama


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