REFERENCE RANGE OF HEART RATE VARIABILITY AND VALIDATION IN SUBJECTS WITH ASYMPTOMATIC ELEVATED LIVER FUNCTION ENZYMES
The prevalence and severity of autonomic dysfunction appears to be related to the severity of liver disease (e. g. alcoholic cirrhosis) and is associated with an increase in mortality. This study aims to evaluate time domain parameters of heart rate variability in asymptomatic liver functions elevated healthy subjects and comparison of it with normal population reference range. The rationale of the study is that increasing severity of liver failure is associated with a reduction in total heart rate variability and regularity; therefore measurement of HRV offers a simple, noninvasive means of assessing the cardiovascular and autonomic effects of liver disease.
The finding of the current study shows that Heart rate variability of Liver functions elevated subjects are found to be higher than the normal population reference range. The reason for finding of higher variability was that subjects included in this study had bradycardia. Bradycardia is known to lead to higher heart rate variability.Keywords: Heart rate variability, Autonomic nervous system, Liver Functions.
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