• Kolli Sravani
  • Dharavatu Priyanka School of Pharmaceutical Sciences & Technologies, Jawaharlal Nehru Technological University, Kakinada, Andhra Pradesh, India.
  • R. Sravani
  • K. Srinivas Reddy
  • D. Vinay Kumar


Vildagliptin belongs to a class of orally active anti-diabetic drug which inhibits dipeptidyl peptidase-4(DPP-4) and to potentiate the secretion of insulin in the β-cells, there by decreasing blood glucose level. Vildagliptin is a short half life drug so it needs to formulate into sustained release dosage form to reduce dose frequency for patient compliance. Among various techniques, formulation of matrix tablets using matrix formers is a simple and industrially useful technique in the design of sustained release drug delivery systems. In the present study, an attempt has been made to develop sustained release matrix tablets of Vildagliptin using hydrophilic polymers like HPMC (k15M, K100M) and Carbapol by using wet granulation method. Dissolution study was done by using type-II dissolution apparatus gave good results with combination of HPMC K100 M and Carbapol. Drug release from the formulation follows zero order, first order, Higuchi’s equation, and korsemeyer’s equation.

Keywords: Vildagliptin, Anti-diabetic drug, Sustained release dosage form, Matrix formers, Wet granulation. 


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How to Cite
Sravani, K., D. Priyanka, R. Sravani, K. S. Reddy, and D. V. Kumar. “FORMULATION AND EVALUATION OF VILDAGLIPTIN SUSTAINED RELEASE MATRIX TABLETS”. International Journal of Current Pharmaceutical Research, Vol. 6, no. 4, 1, pp. 69-75,
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