PHARMACOLOGICAL EFFECT OF POLYSORBATE 80 IN CANCER CHEMOTHERAPY


J. Beeba, F. Anwar, S. Susheel

Abstract


Objective- Tween 80 (Polysorbate 80) is a classical non-ionic surface-active detergent. It is widely used as an additive in pharmaceuticals and in the food industry. Many of the Tweens are considered to be carcinogens. Here in this study an attempt was made to find out whether the tween 80  used as an excipient in an anti cancer drug, Methotrexate affected its therapuetic efficiency or not.

Method- Hepatocellularcarcinogenesis (HCC) was induced in the wister rats by the administration of a single dose chemical carcinogen DENA (150 mg/kg i. p.). The animals exposed to DENA were treated with pure Methotrexate (MTX) and marketed MTX (0.14mg/kg by oral route through force feeding) and Tween 80 (0.14mg/kg by p. o.).

Result- Exposure of DENA and Tween 80 elevated the levels of SGOT, SGPT, ALP, and AFP in Wistar rats. Histopathological examinations of the liver tissue showed marked carcinogenicity of the chemical carcinogen and excipients, while pure MTX treated group showed normal liver cell architecture.

Conclusion- The study revealed that the excipient polysorbate 80 used in the marketed formulation of Methotrexate decreased the efficacy of the  pure drug (pure Methotrexate).

Keywords: Polysorbate80 , Excipient, Efficacy, Diethylnitrosamine(DENA), Hepatocarcinogenesis, Methotrexate (MTX).


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About this article

Title

PHARMACOLOGICAL EFFECT OF POLYSORBATE 80 IN CANCER CHEMOTHERAPY

Date

07-10-2014

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 6, Issue 4 (Oct-Dec 2014) Page: 83-87

Online ISSN

0975-7066

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724 Views | 348 Downloads

Authors & Affiliations

J. Beeba
1Department of Pharmaceutical Chemistry, Siddharta Institute of Pharmacy, Dehardun, Uttrakhand State, India, 2Department of Pharmacology, Siddharta Institute of Pharmacy, Dehardun, Uttrakhand State, India.

F. Anwar

S. Susheel


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