DEVELOPMENT, EVALUATION AND CHARACTERISTICS OF OPHTHALMIC IN SITU GEL SYSTEM: A REVIEW
Keywords:In-situ gel, Novel ocular delivery, Phase transition, Temperature, pH triggered
Eye is a sensitive organ and is easily injured and infected. Delivery of drugs into eye is complicated due to removal mechanism of precorneal area results decrease in therapeutic response. Conventional ocular delivery systems like solution, suspension, ointment shows some disadvantages such as rapid corneal elimination, repeated instillation of drug and short duration of action. In situ polymeric delivery system will help to achieve optimal concentration of drug at the target site, thereby helps to achieve the desired therapeutic concentration. There are various novel ocular drug delivery systems such as In-situ gel, dendrimers, niosomes, nanoparticulate system, collagen shield, ocular iontophoresis suspension and ocusert etc. In situ gelling systems are liquid upon instillation and undergo a phase transition to form gel due to some stimuli responses such as temperature modulation, change in pH and presence of ions. Various attempts have been made towards the development of stable sustained release in-situ gels. Newer research in ophthalmic drug delivery systems is directed towards an incorporation of several drug delivery technologies, that includes to build up systems which is not only extend the contact time of the vehicle at the ocular surface, but which at the same time slow down the removal of the drug. This is a review based on ocular in situ gels, characteristization, techniques and evaluation of in situ ophthalmic drug delivery systems,
2. Kumar L, Singh RP, Singh SG, Kumar D. In situ gel: a novel system for ocular drug delivery. Int J Pharm Sci Rev Res 2011;9:83-91.
3. Ravikumar PS, Pashte S. In-situ ophthalmic gel forming solution of moxifloxacin hydrochloride for sustained ocular delivery. Int J Phrm Sci Res 2015;34:1192-205.
4. Baranowski PB, Karolewicz B, Gajda M. Ophthalmic drug dosage forms: characterisation and research methods. Sci world J 2014;2:4-6.
5. Nirmal HB, Bakliwal SR. In-situ gel: new trends in controlled and sustained drug delivery system. Int J Phrm Tech Res 2010;2:1398-410.
6. Rathore KS, Nema RK, Ishibashi T, Yokoi N, Born JA, Tiffany MJ, et al. Review on ocular inserts. Int J Pharm Tech Res 2009;1:164-9.
7. Dale SA, Cynthia MB. Ophthalmic preparations. Stimuli Revision Process 2013;39:1-5.
8. Gupta H, Jain S, Mathur R, Mishra P, Mishra AK. Sustained ocular drug delivery from a temperature and PH triggered novel in-situ gel system. Drug Delivery 2007;14:507–15.
9. Rajoria G, Gupta A. In-situ gelling system: a novel approach for ocular drug delivery. Am J Pharm Tech Res 2012;2:25-53.
10. Rajas NJ, Kavitha K, Gounder T, Mani T. In-situ ophthalmic gels a developing trend. Int J Pharm Sci Rev Res 2011;7:8-14.
11. Nanjundswamy NG, Fatima SD, Sholapur HN. A review on hydrogels and its use in in situ ocular drug delivery. Indian J Novel Drug Delivery 2009;1:11-7.
12. Mohanambal E, Arun K, Abdul Hasan SA. Formulation and evaluation of pH-triggered in-situ gelling system of levofloxacin. Indian J Pharm Edu Res 2011;45:58-64.
13. Shastri D, Pandya H, Parikh RK, Patel CN. Smart hydrogels in controlled drug delivery. Pharma Times 2006;38:13-8.
14. El-Kamel AH. In vitro and in vivo evaluation of pluronic F 127 based ocular delivery system for timololmaeate. Int J Pharm 2002;241:47-55.
15. Liu Z, Li J, Nie S, Hui-Liu, Ding P, Pan W. Study of alginate/HPMC based in situ gelling ophthalmic delivery system for gatifloxacin. Int J Pharm 2006;315:12-7.
16. Soniya R, Devasani, Asish Dev S. An overview of in situ gelling systems. Pharm Bio Evaluation 2016;3:61-9.
17. Tinu TS, Thomas L, Kumar AB. Polymers used in ophthalmic in situ gelling system. Int J Pharm Sci Rev Res 2013;20:176-83.
18. Kumar L, Singh RP, Singh SG, Kumar D. In situ gel: a novel system for ocular drug delivery. Int J Pharm Sci Rev Res 2011;9:83-91.
19. Talat F, Sadhana RS, Azmat MS, Nityanand Z, Syed A. Formulation development and evaluation of in situ ophthalmic gel of sodium cromoglycate. Der Pharm Sin 2013;4:109-18.
20. Agarwal KM, Namdev A, Gupta AK. In situ gel formation for ocular drug delivery system: an overview. Asian J Bio Pharm Sci 2011;1:1-7.
21. Nittur JR, Kunchu K, Theetha G, Tamizh M. Review on in situ ophthalmic gels: a developing trend. Int J Pharma Sci Rev Res 2011;7:8-14.
22. Shin SC, Kim JY, Oh IJ. Mucoadhesive and physicochemical characterization of carbopol-poloxamer gels containing triamcinolone acetonide. Drug Dev Ind Pharm 2000;26:307-12.
23. Rajoia G, Gupta A. In situ gelling system: a novel approach for ocular drug delivery. Am J Pharm Tech Res 2012;2:25-53.
24. Vengurlekar P, Singh A, Rathod S. Microspheric in situ gel for ocular drug delivery system of bromfenac sodium. Int J Pharma Sci Res 2014;5:179-85.
25. Gambhire S, Bhalerao K, Singh S. Review on in situ hydrogel: different approaches to ocular drug delivery. Int J Pharm Pharm Sci 2013;5:27-36.
26. Madan M, Bajaj A. In situ forming polymeric drug delivery systems. Indian J Pharm Sci 2009;1:242-3.
27. Rathore KS, In situ gelling ophthalmic drug delivery system: an overview. Int J Pharm Pharm Sci 2015;2:1-22.