• VISHWAS T. S. Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru 570015, India
  • GURUPADAYYA B. M. Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru 570015, India


Objective: The current work is intended towards the development of a novel, simple, and precise UV spectrophotometric method for the estimation of teriflunomide (TEF) present in the marketed formulation.

Methods: Acetonitrile was used as asolvent and the absorbance of the drug was measured at the absorbance maxima of TEF, UV 284 nm.

Results: Calibration curve plotted in concentration range 5-10 µg /ml exhibited excellent linear relationship with line equation y = 0.0858x-0.0223 and r2 value of 0.9996. The method was found to comply all the validation parameters as per the ICH guideline indicating the sensitivity of the method towards analyte.

Conclusion: The method can be used satisfactorily for the routine analysis of TEF present in marketed formulation.

Keywords: UV spectrophotometric, Teriflunomide, Marketed formulation, ICH guideline, Sensitivity


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How to Cite
T. S., V., and G. B. M. “NOVEL UV SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF TERIFLUNOMIDE IN TABLET DOSAGE FORM”. International Journal of Current Pharmaceutical Research, Vol. 11, no. 5, Sept. 2019, pp. 81-84, doi:10.22159/ijcpr.2019v11i5.35711.
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