THE INFLUENCE OF VARIATION OF HYDROXYPROPYL METHYLCELLULOSE AND TWEEN 80 CONCENTRATIONS ON PHYSICAL CHARACTERISTICS AND PHYSICAL STABILITIES GEL OF WATER DRY EXTRACT OF TEMULAWAK
Objective: Water extract of temulawak (Curcuma xanthorrhizaRoxb.) contains curcumin, which known has antibacterial, antiinflammation, and antifungal activity so that it has potential used as wound healing. The purpose of this study was formulating gel of water extract of temulawak made by variation of hydroxypropyl methylcellulose (HPMC) and tween 80 concentrations and investigating the influence of formulations on physical characteristics and physical stabilities gel.
Methods: Gel was made by variation of HPMC and tween 80 concentrations (3,00%: 1,00%; 5,00%: 1,00%; 3,00%: 2,00%; 5,00%; 2,00%). Gel preparations was evaluated the physical characeristics by organoleptic test, homogeneity test, pH, viscosity, spreadability, adhesiveness, and stability. The physical properties were analyzed by software Design Expert 9.
Results: The results showed that HPMC has dominant influenced on viscosity, spreadability, and adhesiveness. HPMC and tween 80 have not influence on organoleptic, homogeneity, and pH of the gel. Optimum formula is HPMC 5,00% and tween 80 1,00%. Optimum formula is stable on organoleptic, homogeneity, pH, viscosity, and adhesiveness; however spreadability of gel is not stable during 3 mo storage.
Conclusion: Variation of HPMC and tween 80 concentrations influenced viscosity, spreadability, and adhesiveness, while they were not influenced on organoleptic, homogeneity, and pH of gel. HPMC had dominant influenced on viscosity, spreadability, and adhesiveness gel.
2. Posluszny JA, Conrad P, Halerz M, Shankar R, Gamelli RL. Surgical burn wound infections and their clinical implications. J Burn Care Res 2011;32:324–33.
3. Cancio LC, Howard PA, McManus AT, Kim SH, Goodwin CW, BA Pruitt J. Burn wound infections [Internet]. Zuckschwerdt Tersediapada; 2001. Available from: https://www.ncbi.nlm.nih.gov/books/NBK6970/ [Last accessed on 23 Sep 2018]
4. Gunes H, Gulen D, Mutlu R, Gumus A, Tas T, Topkaya AE. Antibacterial effects of curcumin: an in vitro minimum inhibitory concentration study. ToxicolInd Health 2016;32:246-50.
5. Neelofar K, Shreaz S, Rimple B, Muralidhar S, Nikhat M, Khan LA. Curcumin as a promising anticandidal of clinical interest. Can J Microbiol 2011;57:204–10.
6. Boateng JS, Matthews KH, Stevens HNE, Eccleston GM. Wound healing dressings and drug delivery systems: a review. J Pharm Sci 2008;97:2892–923.
7. Rogers T. Hypromellose. Dalam: Handbook of Pharmaceutical Excipients. 6 ed. London: Pharmaceutical Press. Inc; 2009.
8. Williams AC, Barry BW. Penetration enhancers. Adv Drug Delivery Rev 2004;56:603–18.
9. Pongjanyakul T, Kanjanabat S. Influence of pH modifiers and HPMC viscosity grades on nicotine-magnesium aluminum silicate complex-loaded buccal matrix tablets. AAPS PharmSciTech 2012;13:674–85.
10. Fasolin LH, Picone CSF, Santana RC, Cunha RL. Production of hybrid gels from polysorbate and gellan gum. Food Res Int 2013;54:501–7.
11. Naiya TK, Kumar R, Mohapatra S, Mandal A. Studies on the effect of surfactants on rheology of synthetic crude. J Pet Sci Res 2014:1-7. Avalaible from: http://dpi-journals.com/index.php/JPSR/article/view/1009. [Last accessed 23 Sep 2018]
12. Garg A, Aggarwal D, Garg S, Singla AK. Spreading of semisolid formulations: an update. Pharm Technol North Am 2002;26:84–105.
13. Sinko PJ. Martin’s physical pharmacy and pharmaceutical sciences. Sixth, North American edition. Baltimore, Lippincot William and Wilkins; 2010.
14. Swastika A, Mufrod M, Purwanto P. Antioxidant activity of cream dosage form of tomato extract (Solanumlycopersicum L.). Traditional Med J 2015;18:132–40.
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