ANTIHYPERGLYCEMIC ACTIVITY OF IMPERATA CYLINDRICA ROOT METHANOL EXTRACT IN RATS

  • RUSLIN Faculty of Pharmacy, Halu Oleo University, Kendari, Southeast Sulawesi, Indonesia
  • VICA ASPADIAH Faculty of Pharmacy, Halu Oleo University, Kendari, Southeast Sulawesi, Indonesia
  • DIAH DHIANAWATY Biochemistry and Biomolecular Laboratory, Medical Faculty, Padjadjaran University, Bandung, West Java, Indonesia

Abstract

Objective: This study aims to evaluate the inhibitory activity of Imperatacylindrica root methanol extract on glucose absorption level in intestine of male Wistar strain rats at a dose of 90 mg/kg-bw, which is a dose having antihypertensive activity.


Methods: Extract inhibitory activity on the glucose absorption level in the intestine of the rats followed Soedigdo-Marsongkohadi method. Glucose absorption level was measured from a mixture of 30 mmol glucose in 0.9 % sodium chloride solution as the control solution and a mixture of the extract at the dose of 90 mg/kg-bw in another control solution as the tested solution


Results: The result showed that the extract at the dose of 90 mg/kg-bw had significant activity (p<0.05) to decrease the glucose absorption level in the intestine of the rats.


Conclusion: I. cylindrica root methanol extract at the dose of 90 mg/kg-bw had a significant activity to inhibit the glucose absorption level in the intestine of the rats. Thereby, the extract at the dose of 90 mg/kg-bw had antihyperglycemic activity.

Keywords: Antihyperglycemic, Cogongrass, Glucose absorption, I. cylindrical

References

1. Chiang YC, Tsai CC, Hsu TW, Chou CH. Characterization of 21 microsatellite markers from cogongrass, Imperata cylindrica (Poaceae), a weed species distributed worldwide. Am J Bot 2012;99:e428-30.
2. Dhianawaty DD. Study of plant ethnopharmacology to cure the bladder stones disease. In: Soemadji AA, Garna H, Setiabudiawan B. ed. Traditional Medicine for the Treatment of Kidney Stone-Bladder Stones Diseases. Jatinangor: Universitas Padjadjaran Press; 2016. p. 24-7.
3. Ruslin, Asmawi MZ, Rianse U, Sahidin I, Dhianawaty D, Soemardji AA, et al. Anti-hypertensive activity of Alang–Alang (Imperata cylindrica (L.) beauv. root methanolic extract on male Wistar rat. Int J Res Pharm Sci 2013;4:537-42.
4. Subramaniam S, Sivasubramanian A. Tradition to therapeutics: sacrificial medicinal grasses desmostachya bipinnata and Imperata cylindrica of India. Bol Latinoam Caribe Plant Med Aromat 2015;14:156-70.
5. An HJ, Nugroho A, Song BM, Park HJ. Isoeugenin, a novel nitric oxide synthase inhibitor isolated from the rhizomes of imperata cylindrica. Molecules 2015;20:21336-45.
6. Dhianawaty D, Ruslin. Total polyphenol content and antioxidant activity of methanol extract of imperata cylindrica (L) Beauv.(Alang-alang) root. Majalah Kedokteran Bandung Mkb Bandung Med J 2015;47:60-4.
7. Dhianawaty DD, Ruslin, Syamsunarno MRAA, Hamimah H. The 54th national seminar of Indonesia medicinal plants. In: Masfria, Agustama, Hasibuan PAZ, Khairunnisa, Mariane, Sitorus P, et al. ed. Total Flavonoid Content of Methanol Extract of I. cylindrica (L) Beauv. (Alang-alang). Medan: North Sumatera University; 2018. p. 36.
8. Dutt R, Pushpan R, Kumari H, Nishteswar K. Cirrhosis of liver-care by indigenous and folk herbal medicine. Int Res J Pharm 2012;3:1-3.
9. Parvathy NG, Padma R, Renjith V, Rahate KP, Saranya TS. Phytochemical screening and anthelmintic activity of methanolic extract of imperata cylindrica. Int J Pharm Pharm Sci 2012;4:232-4.
10. Ojha SN, Nagore DH, Ganu GP. In vitro and in vivo anticoagulant activity of I. cylindrical a novel anticoagulant lead from natural origin. Phcog Net 2010;2:38-43.
11. Parkavi V, Vignesh M, Selvakumar K, Muthu JM, Joysa JR. Antibacterial activity of aerial parts of Imperata cylindrica (L) beauv. Int J Pharm Sci Drug Res 2012;4:209-12.
12. Chan LW, Cheah EL, Saw CL, Weng W, Heng PW. Antimicrobial and antioxidant activities of cortex magnoliae officinalis and some other medicinal plants commonly used in South-East Asia. Chin Med 2008;3:15.
13. Nurhayati N, Widowati L. The use of traditional health care among Indonesian Family. Health Sci J Indonesia 2017;8:30-5.
14. Regulation of The Minister of Health of Republic Indonesia Number 39 Y 2016 Concerning Guidelines for Healthy Program Implementation with Family Approach. Available from: http://www.depkes.go.id/resources/download/lain/PMK_No.39_ttg_PIS_PK. pdf. [Last accessed 20 Mar 2018]
15. Strategic Plan of Ministry of Health in 2015-2019; 2015. Available from: http://www.depkes.go.id/resources/ download/ info-publik/Renstra-2015.pdf. [Last accessed on 20 Mar 2018]
16. World Health Organization. Noncommunicable diseases: more about noncommunicable diseases; 2018. Available from: www.who.int›News›Fact sheets. [Last accessed 09 Jun 2018]
17. World Life Expectancy Health Profile: Indonesia; 2017. Available from: http://www.worldlifeexpectancy.com/world-health-rankings. [Last accessed 09 Mar 2018].
18. Dhianawaty D, AMS SS. Effect of curcuma longa l. rhizome decoct on glucose absorption level in Intestine of male rat of wistar strain. Int J Pharm Pharm Sci 2014;6:532-5.
19. Epriliati I, Ginjom IR. Bioavailability of phytochemicals. Phytochemicals-a global perspective of their role in nutrition and health, Rao V. ed. InTech, Rijeka, Croatia; 2012. p. 401-28.
20. Marcovecchio ML. Complications of acute and chronic hyperglycemia. US Endocrinol 2017;13:1-17.
21. Popov D. Endothelial cell dysfunction in hyperglycemia: phenotypic change, intracellular signaling modification, ultrastructural alteration, and potential clinical outcomes. Int J Diabetes Mellitus 2010;2:189-95.
22. Zhao Y, Vanhoutte PM, Leung SW. Vascular nitric oxide: Beyond eNOS. J Pharmacol Sci 2015;129:83-94.
23. Rajendran P, Rengarajan T, Thangavel J, Nishigaki Y, Sakthisekaran D, Sethi G, et al. The vascular endothelium and human diseases. Int J Biol Sci 2013;9:1057.
Statistics
74 Views | 74 Downloads
Citatons
How to Cite
RUSLIN, V. ASPADIAH, and D. DHIANAWATY. “ANTIHYPERGLYCEMIC ACTIVITY OF IMPERATA CYLINDRICA ROOT METHANOL EXTRACT IN RATS”. International Journal of Current Pharmaceutical Research, Vol. 12, no. 3, May 2020, pp. 140-3, doi:10.22159/ijcpr.2020v12i3.38324.
Section
Original Article(s)