ANTAGONISTIC EFFECT OF MUSK ON ORGANISMS DIFFERENT TYPES

  • JANA ABDUL MOHSEN ALJURISS Botany and Microbiology Department, Students of College of Sciences, King Saud University, Riyadh,12824, Saudi Arabia
  • NOURA SAUD ALNAJEM Botany and Microbiology Department, Students of College of Sciences, King Saud University, Riyadh,12824, Saudi Arabia
  • FAHDAH FAHAD ALGHOFAILI Botany and Microbiology Department, Faculty of College of Sciences, King Saud University
  • TURKI N. AL-ARIFI Department of Bacteriology, Laboratory Specialist of Regional Laboratory and Blood Bank, King Saud Medical City
  • FATIMAH S. AL-KHATTAF Botany and Microbiology Department, Faculty of College of Sciences, King Saud University

Abstract

Objective: This study aims to The research aimed at a comparative study the effect of natural and synthetic musk compared to creams that have an anti-fungal and anti-bacterial effect on the growth of Candida albicans that causes vaginal diseases in women, as well as the growth of the bacteria strains include Staphylococcus aureus, Bacillus subtilis, which would be more effective in inhibiting the growth of these microbes and Achieve the recommendation of the Prophet Muhammad for women to treat the vagina with natural musk, find alternatives to synthetic antibiotics, and reduce their negative effects on human health.


Methods: This study investigates the antagonistic effect of Anti fungal and bacterial Cream and different natural type {Musk (N. M), Black Musk (B. M)} and chemical Musk {white Musk (W. M), cream Musk (M. C) } on some microorganisms. The types of yeast Candida albicans HVS and the bacteria strains include Staphylococcus aureus, Bacillus subtilis, were tested by means of disk diffusion,


Results: Results indicated that Musk has inhibitory effects on the growth of study microorganisms Musk contains active substances similar to antibiotic, alkaloids and volatile oils present in them as they have the ability to stop the growth of many microorganisms. The effect of natural musk was higher than the effect synthetic musk, And the microbes were the most sensitive to musk is Bacillus subtilis. As for anti-microbial creams, the effect of the anti-bacterial cream was more effective in their suppression compared to all kinds of musk unlike the anti-fungal cream which gave a negative result.


Conclusion: This study showed that the different concentrations of natural musk have an effective role in inhibiting some of the microbes of this vaginal pathogen, and it has given a positive opposite result to these microbes, and therefore it can be used as a natural antibiotic that reduces side effects on females and the environment.

Keywords: Musk, Microorganisms, Antagonistic, Pathogenic

References

1. Leung E, Weil DE, Raviglione M, Nakatani H. The WHO policy package to combat antimicrobial resistance. Bulletin World Health Organization 2011;89:390-2.
2. Black JG. Microbiology principles and application. Prentice Hall Inc 1996;3:563-55.
3. Hassawi D, Kharma A. Antimicrobial activity of some medicinal plants against candida albicans. J Biol Sci 2006; 6:109.
4. Saddiq AA. Potential effect of natural musk and probiotic on some pathogens strain. Int Res J Microbiol 2011;2:146-52.
5. Badawy AF, Elleboudy NA, Hussein HM. Assessment of in vitro anti-trichomonas vaginalis activity of deer musk. Int J Adv Res 2014;2:668-78.
6. AL-Jobori KM, AL-Khafagi NA, Witwit NM. Evaluation of the antagonistic effect of musk on eleven bacterial strains and three types of yeast. Topc J Microbiol 2014;2:1-6.
7. Saddiq AN, El-Elyani RA. Liver mycotoxicosis treated with musk and sidr extract. Egyptian J Exper Biol Egypt Tanata; 2009. p. 17-29.
8. Lai JH. Pharmacognosy. Taipei: Chuang-I Press; 1976. P. 541.
9. Oh SR, Lee JP, Chang SY, Shin DH, Ahn KS, Min BS, et al. Androstane alkaloids from musk of moschus moschiferus. Chem Pharm Bull 2002;50:663-4.
10. Thevis M, Schanzer W, Geyer H, Thieme D, Grosse J, Rautenberg C, et al. Traditional Chinese medicine and sports drug testing: identification of natural steroid administration in doping control urine samples resulting from musk (pod) extracts. Br J Sports Med 2013;47:109-14.
11. Sommer C. The role of musk and musk compounds in the fragrance industry. In: Series Anthropogenic Compounds. Springer, Berlin, Heidelberg; 2004. p. 1-16.
12. Leung AY. Encyclopedia of common natural ingredients used in food, drugs, and cosmetics. Wiley; 1980.
13. Kobayashi GS, Medoff G. Antifungal agents: recent developments. Annual Rev Microbiol 1977;31:291-308.
14. Saddiq AA, Kalifa SA. Impact of fungal content of some Arabic nuts to induce kidney toxicity and agonistic action of natural resources. Afr J Microbiol Res 2011;5:1046-56.
15. Pilz W. Der moschusduft-eine parfumhistorische betrachtung. SEPAWA Kongreßzeitschrift; 1997. p. 43-7.
16. Kun Ying Yen. The illustrated Chines Materia Medica. Crude and Prepared. SMC Publishing Inc. Taipei, Taiwan; 1992. p. 383.
17. Gaski AL, Johnson KA. Prescription for extinction: endangered species and patented oriental medicines in trade/Andrea L. Gaski, Kurt A. Johnson. Traffic USA; 1994.
18. Cheng DH, Jian WANG, Nan ZENG, XIA HL, Yong FU, Dan YAN, et al. Study on drug property differences of shexiang (moschus) and bingpian (borneolumsynthcticum) based on analysis of biothermodynamics. J Trad Chin Med 2011;31:21-6.
19. Yang Q, Feng Z. The status and the sustainable use of musk deer in China. The resource of vertebrate animals in Sichuan. Sichuan Science and Technology Press: Chengdu; 1999.
20. Homes V. On the scent: conserving musk deer–the uses of musk and Europe’s role in its trade. TRAFFIC Europe, Brussels, Belgium; 1999.
21. Saddiq AA. The use of musk as an antibiotic against fungi and yeasts. Patented, King Abdul Aziz City for Science and Technology. Riyadh, SA; 2004.
22. AL-Jobori KM, AL-Ameed AI, Witwit NM. In vitro antifungal activity of musk. Bull Environ Pharmacol Life Sci 2015;4:38-44.
23. Chateau L. Alternatives to antibiotics from nature. Jarir Bookstore, Saudi Arabia. Edn. 2; 2004. p. 29-36.
24. Reynolds JEF, Prasad AB, Shoutman SC. Martindal direction of the council of the pharmaceutical society Britain and prepared in the society,s department of pharmaceutical science. 31st edition; 1996. p. 393960.
25. Cowan MM. Plant products as antimicrobial agents. Clin Microbiol Rev 1999;12:564-82.
26. Elliott T, Worthington T, Osman H, Gill M. Medical microbiology and infection. (4th ed.) Blackwell Publishing Ltd., Oxford, U. K.; 2007.
27. Saddiq AAN. Antiagnostic effect of musk and sidr leaves on some of the opportunistic fungi that cause lung toxicity. Life Sci J 2014;11:99-108.
28. Ekwenye UN, Elegalam NN. Antibacterial activity of ginger (Zingiberofficinale Roscoe) and garlic (Allium sativum L.) extracts on Escherichia coli and Salmonella typhi. Int J Mol Adv Sci 2005;1:411-6.
29. Mottaleb MA, Brumley WC, Sovocool GW. Nitro musk metabolites bound to carp hemoglobin: determination by GC with two MS detection modes: EIMS versus Electron Capture negative ion MS. Int J Environ Anal Chem 2004;84:1069-78.
Statistics
33 Views | 34 Downloads
Citatons
How to Cite
ALJURISS, J. A. M., N. S. ALNAJEM, F. F. ALGHOFAILI, T. N. AL-ARIFI, and F. S. AL-KHATTAF. “ANTAGONISTIC EFFECT OF MUSK ON ORGANISMS DIFFERENT TYPES”. International Journal of Current Pharmaceutical Research, Vol. 12, no. 5, Sept. 2020, pp. 90-94, doi:10.22159/ijcpr.2020v12i5.39777.
Section
Original Article(s)