• RANJEETA GHOLVE Department of Science, Maharaja Agrasen School, Memnagar, Ahmedabad, Gujarat, India
  • DHANESHWAR SHEP Troikaa Pharmaceuticals Ltd, Commerce House 1, Bodakdev, Ahmedabad, Gujarat, India
  • PRAKASHCHANDRA GADE Department of Pharmacology, Dr. Vithalrao Vikhe Patil Foundation's Medical College and Hospital, Ahmednagar, Maharashtra, India
  • MANISH RAMAVAT Department of Physiology, GMERS Medical College, Dharpur, Patan, Gujarat, India


Objective: To study the effect of Cimetidine (H2 receptor antagonist) in combination with Glipizide (Sulfonylurea) on the blood sugar level in rabbits.

Methods: Six albino rabbits were taken for the study. Glipizide was administrated to each rabbit as a single drug therapy on day 1 and it was co-administrated with Cimetidine to each rabbit as a combinational drug therapy on day 7. Cimetidine was administrated to each rabbit from day 2 to day 6 as single drug therapy. Blood sugar levels were estimated on day 1 and on day 7 at 0, 1, 2, 4, and 6 h.

Results: The mean blood sugar level readings at 0, 1, 2, 4 and 6 h on day 1 were 90.4, 69.4, 62.9 and 65.7 mg% and on day 7 were 89.4, 74.8, 65.5, 56.4 and 61.2 mg % respectively. When mean blood sugar level on day 1 and day 7 was considered, there was a significant reduction in blood sugar level at 1, 2, 4 and 6 h and there was no significant fall in blood sugar level at 0 hour after co-administration of Glipizide and Cimetidine.

Conclusion: Cimetidine, when co-administered with Glipizide, significantly increases the hypoglycaemic action of Glipizide.

Keywords: Cimetidine, Glipizide, Hypoglycaemic, Blood sugar


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How to Cite
GHOLVE, R., D. SHEP, P. GADE, and M. RAMAVAT. “A STUDY ON DRUG-DRUG INTERACTION BETWEEN GLIPIZIDE AND CIMETIDINE IN RABBITS”. International Journal of Current Pharmaceutical Research, Vol. 13, no. 2, Mar. 2021, pp. 17-18, doi:10.22159/ijcpr.2021v13i2.41545.
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